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- 1From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedHypertension is a risk factor for many serious health conditions, including stroke, end-stage renal disease, and heart disease. However, in most patients, the underlying cause is unknown. Increased understanding of the...
- 2From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedMicrobes transmitted to mammals by arthropods contend with many factors that could impede survival. To survive, host fitness with infection must outweigh costs. In this issue of the JCI, Neelakanta et al. demonstrate...
- 3From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedIn the United States, Ixodes scapularis ticks overwinter in the Northeast and Upper Midwest and transmit the agent of human granulocytic anaplasmosis, Anaplasma phagocytophilum, among other pathogens. We now show that...
- 4From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedThere are several challenges to be overcome if therapeutic anticancer vaccines, which are designed to boost the patient's anticancer immune response, are to be successfully developed. For example, more effective ways to...
- 5From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedshRNA overexpression from viral gene therapy vectors can trigger cytotoxicity leading to organ failure and lethality in mice and rats. This process likely involves saturation of endogenous cellular RNAi factors...
- 6From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedThe body's capacity to restore damaged neural networks in the injured CNS is severely limited. Although various treatment regimens can partially alleviate spinal cord injury (SCI), the mechanisms responsible for...
- 7From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedCystic fibrosis (CF) is a recessive disease that affects multiple organs. It is caused by mutations in CFTR. Animal modeling of this disease has been challenging, with species-and strain-specific differences in organ...
- 8From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedGlaucoma, a leading cause of blindness worldwide, is characterized by progressive optic nerve damage, usually associated with intraocular pressure. Although the clinical progression of the disease is well defined, the...
- 9From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedSome cancers have been stratified into subclasses based on their unique involvement of specific signaling pathways. The mapping of human cancer genomes is revealing a vast number of somatic alterations; however, the...
- 10From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedIn the preface of her book, Victoria Braithwaite, with a humble vocabulary and an exquisite tone, accepts that she must look with open eyes at the recent controversy (for which she has been largely blamed) surrounding...
- 11From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedCystic fibrosis (CF) is caused by defects in the CFTR, a cAMP-activated [Cl.sup.-] channel of epithelia. The resulting reduction in epithelial fluid transport creates abnormally viscous secretions from airway mucous...
- 12From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedRecombinant activated protein C (aPC) improves the survival of patients with severe sepsis, but the precise molecular and cellular targets through which it mediates this effect remain incompletely understood. In this...
- 13From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedInappropriate and excessive production of the cytokines IL-17 and IL-21 has been linked to the pathogenesis of several autoimmune disorders, including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)....
- 14From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedActivated protein C (aPC) therapy reduces mortality in adult patients with severe sepsis. In mouse endotoxemia and sepsis models, mortality reduction requires the cell signaling function of aPC, mediated through...
- 15From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedThe hallmark of human Mycobacterium tuberculosis infection is the presence of lung granulomas. Lung granulomas can have different phenotypes, with caseous necrosis and hypoxia present within these structures during...
- 16From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedDramatic advances in the field of stem cell research have raised the possibility of using these cells to treat a variety of diseases. The eye is an excellent target organ for such cell-based therapeutics due to its...
- 17From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedAge-related macular disease (AMD) accounts for more than 50% of blind registration in Western society. Patients with AMD are classified as having early disease, in which visual function is well preserved, or late...
- 18From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedTranslational control plays a key role in late spermiogenesis. A number of mRNAs encoding proteins required for late spermiogenesis are expressed in early spermatids but are stored as translationally inactive messenger...
- 19From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedNew prophylactic approaches are needed to control infection with the Gram-positive bacterium Staphylococcus aureus, which is a major cause of nosocomial and community-acquired infections. To develop these, greater...
- 20From: Journal of Clinical Investigation. (Vol. 120, Issue 9) Peer-ReviewedThrough a series of complex transformations, the pixel-like input to the retina is converted into rich visual perceptions that constitute an integral part of visual recognition. Multiple visual problems arise due to...