Showing Results for
- Academic Journals (48)
Search Results
- 48
Academic Journals
- 48
- Search Terms:
- 1From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedThe majority of human skeletal dysplasias are caused by dysregulation of growth plate homeostasis. As TGF-β signaling is a critical determinant of growth plate homeostasis, skeletal dysplasias are often associated with...
- 2From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedSomatic activating mutations in Notch1 contribute to the pathogenesis of T cell acute lymphoblastic lymphoma (T-ALL), but how activated Notch1 signaling exerts this oncogenic effect is not completely understood. Here we...
- 3From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedHepcidin is a peptide hormone that regulates iron homeostasis and acts as an antimicrobial peptide. It is expressed and secreted by a variety of cell types in response to iron loading and inflammation. Hepcidin mediates...
- 4From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedMetformin has become a mainstay in the modest therapeutic armamentarium for the treatment of the insulin resistance of type 2 diabetes mellitus. Although metformin functions primarily by reducing hepatic glucose output,...
- 5From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedNKT cells demonstrate antitumor activity when activated to produce Th1 cytokines by DCs loaded with [alpha]-galactosylceramide, the prototypic NKT cell-activating glycolipid antigen. However, most patients do not have...
- 6From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedNearly every extracellular ligand that has been found to play a role in regulating bone biology acts, at least in part, through MAPK pathways. Nevertheless, much remains to be learned about the contribution of MAPKs to...
- 7From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedDr Horwitz, Members of the Association, and Guests: the Kober Medal has always had a special meaning to me because of the extraordinary careers and accomplishments of the previous recipients. Consequently, it is hard to...
- 8From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedThe inhibitory receptor programmed death 1 (PD-1) is upregulated on antigen-specific [CD8.sup.+] T cells during persistent viral infections. Interaction with PD-1 ligand 1 (PD-L1) contributes to functional exhaustion of...
- 9From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedThe bizarre double life of Dr. William Stewart Halsted Gerald Imber Kaplan Publishing. New York, New York, USA. 2010. 412 pp. $25.95. ISBN: 978-1-6071-4627-8 (hardcover). This biography is the first of...
- 10From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedMetformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was proposed to mediate the action of metformin on hepatic...
- 11From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedIt is now believed that frequent jet lag or shifts of daily rhythms caused by rotating shift work can lead to deleterious health outcomes. Indeed, many serious health problems, including breast cancer, stroke, and...
- 12From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedPDGF-dependent hepatic stellate cell (HSC) recruitment is an essential step in liver fibrosis and the sinusoidal vascular changes that accompany this process. However, the mechanisms that regulate PDGF signaling remain...
- 13From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedTotal body irradiation (TBI) can induce lethal myelosuppression, due to the sensitivity of proliferating hematopoietic stem/progenitor cells (HSPCs) to ionizing radiation (IR). No effective therapy exists to mitigate...
- 14From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedEvan Nair-Gill, Stephanie M. Wiltzius, Xiao X. Wei, Donghui Cheng, Mireille Riedinger, Caius G. Radu, and Owen N. Witte Original citation: J Clin Invest. 2010; 120(6):2005-2015. doi:10.1172/JCI41250. Citation for...
- 15From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedAtherosclerosis represents the most significant risk factor for coronary artery disease (CAD), the leading cause of death in developed countries. To better understand the pathogenesis of atherosclerosis, we applied a...
- 16From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedAutophagy is a tightly regulated catabolic process whereby cells degrade their constituents to dispose of unwanted cytoplasmic elements and recycle nutrients for cellular remodeling. Studies of autophagy in mammals have...
- 17From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedCholesterol is a critical component of cell membranes, and cellular cholesterol levels and distribution are tightly regulated in mammals. Recent evidence has revealed a critical role for pancreatic [beta] cell-specific...
- 18From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedHelen Ranney, research and clinical hematologist extraordinaire, pioneering chair of medicine, professional society president, and soaring intellect, passed away on April 5, 2010, just a week before her 90th birthday...
- 19From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedMAPK signaling pathways are triggered by many of the extracellular ligands that regulate bone homeostasis. Despite this, the relative contribution of specific MAPKs has not been clearly determined. To study the role of...
- 20From: Journal of Clinical Investigation. (Vol. 120, Issue 7) Peer-ReviewedDespite significant advancements in our understanding of cancer development, the molecular mechanisms that underlie the formation of liver cancer remain largely unknown. C/EBP[alpha] is a transcription factor that...