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- 1From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedThe basics of epithelial-mesenchymal transition Raghu Kalluri and Robert A. Weinberg Original citation: J Clin Invest. 2009;119(6):1420-1428. doi:10.1172/JCI39104. Citation for this corrigendum:J Clin...
- 2From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedThe mechanism by which Cryptococcus neoformans invades the central nervous system is fundamental for understanding pathogenesis because cryptococcosis commonly presents as meningoencephalitis. There is evidence for both...
- 3From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedFanconi anemia (FA) is a rare human genetic disease caused by mutations in any one of 13 known genes that encode proteins functioning in one common signaling pathway, the FA pathway, or in unknown genes. One...
- 4From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedPotassium ([K.sup.+]) channels in the inner mitochondrial membrane influence cell function and survival. Increasing evidence indicates that multiple signaling pathways and pharmacological actions converge on...
- 5From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedPolyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE) is a rare human autosomal-recessive disorder characterized by abnormal brain development, cognitive disability, and intractable epilepsy. It is...
- 6From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedGlutaredoxin 5 (GLRX5) deficiency has previously been identified as a cause of anemia in a zebrafish model and of sideroblastic anemia in a human patient. Here we report that GLRX5 is essential for iron-sulfur cluster...
- 7From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedVaccinia virus (VV) vaccination is used to immunize against smallpox and historically was considered to have been successful if a skin lesion formed at the vaccination site. While antibody responses have been widely...
- 8From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedIn the adult heart, regulation of fatty acid oxidation and mitochondrial genes is controlled by the PPAR coactivator-1 (PGC-1) family of transcriptional coactivators. However, in response to pathological stressors such...
- 9From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedBradykinin is the most potent endogenous inducer or acute pain. However, the way in which it excites nociceptive sensory nerve endings is still unclear. In an article recently published in the JCI, Liu et al. suggest a...
- 10From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedChronic stress is associated with hormonal changes that are known to affect multiple systems, including the immune and endocrine systems, but the effects of stress on cancer growth and progression are not fully...
- 11From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedCleft lip and cleft palate, which can also occur together as cleft lip and palate, are frequent and debilitating congenital malformations, with complex geneses that have both genetic and environmental factors...
- 12From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedBrain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function. Correlations...
- 13From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedBrain-derived neurotrophic factor (BDNF) promotes neuronal survival, differentiation, and synaptic function, and altered BDNF expression and/or function has been implicated in several neurodegenerative conditions,...
- 14From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedHDL has anti-atherogenic properties, and plasma levels of HDL cholesterol correlate inversely with risk of coronary artery disease. HDL reportedly functions as a cofactor to the anticoagulant activated protein C (APC)...
- 15From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedNucleotide-binding oligomerization domain 1 (NOD 1) is an intracellular epithelial cell protein known to play a role in host defense at mucosal surfaces. Here we show that a ligand specific for NOD1, a peptide derived...
- 16From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedDid you know that gay men can't donate blood, nor can they donate sperm anonymously to sperm banks? I applaud the 18 senators who have banded together to urge FDA Commissioner Margaret Hamburg to revisit this issue, as...
- 17From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedInfectious meningitis and encephalitis is caused by invasion of circulating pathogens into the brain. It is unknown how the circulating pathogens dynamically interact with brain endothelium under shear stress, leading...
- 18From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedBreast cancer 1, early onset (BRCA1) expression is often reduced in sporadic breast tumors, even in the absence of BRCA1 genetic modifications, but the molecular basis for this is unknown. In this study, we identified...
- 19From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedRegulation of sodium balance is a critical factor in the maintenance of euvolemia, and dysregulation of renal sodium excretion results in disorders of altered intravascular volume, such as hypertension. The...
- 20From: Journal of Clinical Investigation. (Vol. 120, Issue 5) Peer-ReviewedThe CNS is an immune-privileged environment, yet the local control of multiple pathogens is dependent on the ability of immune cells to access and operate within this site. However, inflammation of the distinct...