Showing Results for
- Academic Journals (37)
Search Results
- 37
Academic Journals
- 37
- Search Terms:
- 1From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedThe human epidermis serves 2 crucial barrier functions: it protects against water loss and prevents penetration of infectious agents and allergens. The physiology of the epidermis is maintained by a balance of protease...
- 2From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedA loss of cell polarity is thought to play a critical role in the development of epithelial neoplasias. As the small GTPase Rab25 regulates polarized trafficking to the cell membrane and is expressed throughout the...
- 3From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedTransformation of epithelial cells is associated with loss of cell polarity, which includes alterations in cell morphology as well as changes in the complement of plasma membrane proteins. Rab proteins regulate...
- 4From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedDespite the high doses of radiation delivered in the treatment of patients with glioblastoma multiforme (GBM), the tumors invariably recur within the irradiation field, resulting in a low cure rate. Understanding the...
- 5From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedA global quest for better, cheaper, and fairer health care T.R. Reid Penguin Press. New York, New York, USA. 2009. 277 pp. $25.95. ISBN: 978-1-59420-234-6 (hardcover). T.R Reid's The healing of America is an...
- 6From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedThe liver serves as a target organ for several important pathogens, including hepatitis B and C viruses (HBV and HCV, respectively) and the human malaria parasites, all of which represent serious global health problems....
- 7From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedNeurofibromatosis type 1 (NF1) results from mutations in the NF1 tumor suppressor gene, which encodes the protein neurofibromin. NF1 patients display diverse clinical manifestations, including vascular disease, which...
- 8From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedWolfram syndrome is an autosomal-recessive disorder characterized by insulin-dependent diabetes mellitus, caused by nonautoimmune loss of [beta] cells, and neurological dysfunctions. We have previously shown that...
- 9From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedChikungunya virus (CHIKV) is a mosquito-borne alphavirus that induces in humans a disease characterized by fever, rash, and pain in muscles and joints. The recent emergence or reemergence of CHIKV in the Indian Ocean...
- 10From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedThe receptor tyrosine kinase ret protooncogene (RET) is implicated in the pathogenesis of several diseases and in several developmental defects, particularly those in neural crest-derived structures and the...
- 11From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedJae Young Choi, Monal Khansaheb, Nam Soo Joo, Mauri E. Krouse, Robert C. Robbins, David Weill, and Jeffrey J. Wine Original citation: J Clin Invest. 2009;119(5):1189-1200. doi:10.1172/JCI37284. Citation for this...
- 12From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedChikungunya disease is a severely debilitating, mosquito-borne, viral illness that has reached epidemic proportions in Africa, Asia, and the islands of the Indian Ocean. A mutation enhancing the ability of the...
- 13From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedMaria D'Apolito, Xueliang Du, Haihong Zong, Alessandra Catucci, Luigi Maiuri, Tiziana Trivisano, Massimo Pettoello-Mantovani, Angelo Campanozzi, Valeria Raia, Jeffrey E. Pessin, Michael Brownlee, and Ida Giardino...
- 14From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedThe cellular and molecular events that initiate and promote malignant glioma development are not completely understood. The treatment modalities designed to promote its demise are all ultimately ineffective, leading to...
- 15From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedMany signaling pathways that contribute to tumorigenesis are also functional in pregnancy, although they are dysregulated in the former and tightly regulated in the latter. Transformation-related protein 53 (Trp53),...
- 16From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedKidney and urinary stones and liver toxicity are linked to alterations in oxalate and sulfate homeostasis, respectively. Sulfate anion transporter-1 (Sat1; also known as Slc26a1) mediates epithelial transport of oxalate...
- 17From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedProtein tyrosine phosphatase 1B (PTP1B) and SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) have been shown in mice to regulate metabolism via the central nervous system, but the specific neurons mediating...
- 18From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedMutations in the protoonco-gene rearranged during trans-fection (RET), which encodes two major alternative isoforms of a receptor tyrosine kinase (RET9 and RET51), underlie several diseases and developmental defects,...
- 19From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedUrolithiasis, a condition in which stones are present in the urinary system, including the kidneys and bladder, is a poorly understood yet common disorder worldwide that leads to significant health care costs,...
- 20From: Journal of Clinical Investigation. (Vol. 120, Issue 3) Peer-ReviewedThe chemokines are a large family of mainly secreted molecules involved in the regulation of numerous physiological and pathophysiological processes. Despite many years of investigation, the precise cellular sources of...