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- 1From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedSickle cell disease (SCD) is characterized by intravascular hemolysis and inflammation coupled to a 400-fold greater incidence of invasive pneumococcal infection resulting in fulminant, lethal pneumococcal sepsis....
- 2From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedPDGFR is an important target for novel anticancer therapeutics because it is overexpressed in a wide variety of malignancies. Recently, however, several anticancer drugs that inhibit PDGFR signaling have been associated...
- 3From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedCerebral ischemic small vessel disease (SVD) is the leading cause of vascular dementia and a major contributor to stroke in humans. Dominant mutations in NOTCH3 cause cerebral autosomal dominant arteriopathy with...
- 4From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedResearchers developing new treatments for osteoporosis are looking to design therapeutics that increase the amount and/or quality of bone. However, osteoblast-mediated bone formation is tightly coupled to...
- 5From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedMixed-lineage leukemia (MLL) is a proto-oncogene frequently involved in chromosomal translocations associated with acute leukemia. These chromosomal translocations commonly result in MLL fusion proteins that dysregulate...
- 6From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedPhosphatase inhibitor-1 (I-1) is a distal amplifier element of [beta]-adrenergic signaling that functions by preventing dephosphorylation of downstream targets. I-1 is downregulated in human failing hearts, while...
- 7From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedAhlke Heydemann, Ermelinda Ceco, Jackie E. Lim, Michele Hadhazy, Pearl Ryder, Jennifer L. Moran, David R. Beier, Abraham A. Palmer, and Elizabeth M. McNally Original citation: J Clin Invest. 2009;119(12):3703-3712....
- 8From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedDisruption of mitotic events contributes greatly to genomic instability and results in mutator phenotypes. Indeed, abnormalities of mitotic components are closely associated with malignant transformation and...
- 9From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedAm I making myself clear? A scientist's guide to talking to the public Cornelia Dean Harvard University Press. Cambridge, Massachusetts, USA. 2009. 288 pp. $19.95. ISBN: 978-0-674-03635-2 (hardcover). In...
- 10From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedMetastatic disease is responsible for the majority of human cancer deaths. Understanding the molecular mechanisms of metastasis is a major step in designing effective cancer therapeutics. Here we show that the T-box...
- 11From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedAdjuvants are frequently used to increase the quantity of vaccine-induced T cell immune responses. Stimulating certain pairs of TLRs, a family of microorganism-sensing receptors, has a synergistic effect on the...
- 12From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedThe Rho family GTPases Cdc42 and Rac1 are critical regulators of the actin cytoskeleton and are essential for skin and hair function. Wiskott-Aldrich syndrome family proteins act downstream of these GTPases, controlling...
- 13From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedTGF-[beta] regulates many aspects of cellular performance relevant to tissue morphogenesis and homeostasis. Postnatal perturbation of TGF-[beta] signaling contributes to the pathogenesis of many disease states, as...
- 14From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedTLRs are recognized as promoters of tissue damage, even in the absence of pathogens. TLR binding to damage-associated molecular patterns (DAMPs) released by injured host cells unleashes an inflammatory cascade that...
- 15From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedCellular plasticity in adult organs is involved in both regeneration and carcinogenesis. WT mouse acinar cells rapidly regenerate following injury that mimics acute pancreatitis, a process characterized by transient...
- 16From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedAnna Mandinova, Vihren Kolev, Victor Neel, Bing Hu, Wesley Stonely, Jocelyn Lieb, Xunwei Wu, Claudia Colli, Rong Han, Michael J. Pazin, Paola Ostano, Reinhard Dummer, Janice L. Brissette, and G. Paolo Dotto Original...
- 17From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedMany physiological processes in the skin, including wound healing and hair follicle (HF) cycling, involve actin cytoskeleton reorganization regulated by the Rho family GTPases Cdc42 and Rac1. Consistent with this,...
- 18From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedMyeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a population of immature myeloid cells with the ability to suppress T cell activation. They accumulate in tumor-bearing mice and humans...
- 19From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedEffective osteoporosis therapy requires agents that increase the amount and/or quality of bone. Any modification of osteoclast-mediated bone resorption by disease or drug treatment, however, elicits a parallel change in...
- 20From: Journal of Clinical Investigation. (Vol. 120, Issue 2) Peer-ReviewedComplicated abdominal aortic aneurysm (AAA) is a major cause of mortality in elderly men. Ang II-dependent TGF-[beta] activity promotes aortic aneurysm progression in experimental Marfan syndrome. However, the role of...