Showing Results for
- Academic Journals (45)
Search Results
- 45
Academic Journals
- 45
- Search Terms:
- 1From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedDeleterious immune responses that cause autoimmune diseases such as type 1 diabetes are normally kept in check by a myriad of mechanisms. Among these, protection mediated by [CD4.sup.+][Foxp3.sup.+] Tregs constitutes an...
- 2From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedTh17 cells promote a variety of autoimmune diseases, including psoriasis, multiple sclerosis, rheumatoid arthritis, and inflammatory bowel disease. TGF-[beta] is required for conversion of naive T cells to Th17 cells,...
- 3From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedOutcomes in transplantation have been limited by suboptimal long-term graft survival and toxicities associated with current immunosuppressive approaches. T cell costimulation blockade has shown promise as an alternative...
- 4From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedDuring the differentiation of an erythrocyte, the developing erythroblast shuts down expression of most of its genes but preserves high levels of expression of certain key genes, such as those encoding hemoglobin and...
- 5From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedIncreased sarcoplasmic reticulum (SR) [Ca.sup.2+] leak via the cardiac ryanodine receptor/calcium release channel (RyR2) is thought to play a role in heart failure (HF) progression. Inhibition of this leak is an...
- 6From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedBloodstream infection by highly antibiotic-resistant bacteria, such as vancomycin-resistant Enterococcus (VRE), is a growing clinical problem that increasingly defies medical intervention. Identifying patients at high...
- 7From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedExcessive iron absorption is one of the main features of [beta]-thalassemia and can lead to severe morbidity and mortality. Serial analyses of [beta]-thalassemic mice indicate that while hemoglobin levels decrease over...
- 8From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedB cell lymphoma 6 (BCL6), which encodes a transcriptional repressor, is a critical oncogene in diffuse large B cell lymphomas (DLBCLs). Although a retro-inverted BCL6 peptide inhibitor (RI-BPI) was recently shown to...
- 9From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedDiffuse large B cell lymphoma (DLBCL) is the most common form of non-Hodgkin lymphoma. New drug targets are needed for this aggressive disease because current therapies fail to cure 40% of patients. One promising target...
- 10From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedHaving successfully developed mechanisms to evade immune clearance, hepatitis C virus (HCV) establishes persistent infection in approximately 75%-80% of patients. In these individuals, the function of HCV-specific...
- 11From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedTh17 cells are a distinct lineage of T helper cells that protect the body from bacterial and fungal infection. However, Th17 cells also contribute to inflammatory and autoimmune disorders such as multiple sclerosis....
- 12From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedA lineage of [CD4.sup.+] T cells known as Th17 cells, which are derived by exposure of naive [CD4.sup.+] T cells to IL-6 and TGF-[beta], have been implicated in several autoimmune diseases. In this issue of the JCI,...
- 13From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedMalaria caused by Plasmodium falciparum remains a major public health threat, especially among children and pregnant women in Africa. An effective malaria vaccine would be a valuable tool to reduce the disease burden...
- 14From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedThe development of effective cancer immunotherapies has been consistently hampered by several factors, including an inability to instigate long-term effective functional antitumor immunity. This is particularly true for...
- 15From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedRecent genome-wide association studies have identified a genetic locus at human chromosome 8q24 as having minor alleles associated with lower levels of plasma triglyceride (TG) and LDL cholesterol (LDL-C), higher levels...
- 16From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedIn September, Dario Altieri (Figure 1), former chair of the Department of Cancer Biology at the University of Massachusetts Medical School, took on a new challenge when he was named the director of the Wistar Institute...
- 17From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedHereditary deficiency of the protein [alpha]-1 antitrypsin (AAT) causes a chronic lung disease in humans that is characterized by excessive mobilization of neutrophils into the lung. However, the reason for the...
- 18From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedRetinoblastoma (RB; encoded by RB1) is a tumor suppressor that is frequently disrupted in tumorigenesis and acts in multiple cell types to suppress cell cycle progression. The role of RB in tumor progression, however,...
- 19From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedThe circulating, adipocyte-secreted hormone adiponectin (APN) exerts protective effects on the heart under stress conditions. The receptors binding APN to cardiac tissue, however, have remained elusive. Here, we report...
- 20From: Journal of Clinical Investigation. (Vol. 120, Issue 12) Peer-ReviewedIn situations of stress the heart beats faster and stronger. According to Marks and colleagues, this response is, to a large extent, the consequence of facilitated [Ca.sup.2+] release from intracellular [Ca.sup.2+]...