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- 1From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedMicroRNAs (miRNAs) are potent regulators of mRNA stability and thereby protein expression. As such, miRNAs have become of interest as possible therapeutics and/or therapeutic targets. In this context, small...
- 2From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedAdriamycin (ADR) is a commonly used chemotherapeutic agent that also produces significant tissue damage. Mutations to mitochondrial DNA (mtDNA) and reductions in mtDNA copy number have been identified as contributors to...
- 3From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedImmunotherapies based on adoptive cell transfer are highly effective in the treatment of metastatic melanoma, but the use of this approach in other cancer histologies has been hampered by the identification of...
- 4From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedOn September 8, Johnson & Johnson awarded the 2010 Dr. Paul Janssen Award for Biomedical Research to Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases at the NIH, and Erik De Clercq,...
- 5From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedIndividuals infected with HIV-1 progress to AIDS at different rates. Rapid progressors develop AIDS within 2-5 years of initial infection, compared with approximately 10 years in typical progressors. Progression to AIDS...
- 6From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedMy goodness, Mike, you are spectacular. There ought to be a blessing that says, "May you live long enough to have your mentee become your mentor." As a good mentor, Mike made me look pretty good . . . with limited...
- 7From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-Reviewed
The Fox O3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration
The active thyroid hormone 3,5,3' triiodothyronine (T3) is a major regulator of skeletal muscle function. The deiodinase family of enzymes controls the tissue-specific activation and inactivation of the prohormone... - 8From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedThrombopoiesis, the process by which circulating platelets arise from megakaryocytes, remains incompletely understood. Prior studies suggest that megakaryocytes shed platelets in the pulmonary vasculature. To better...
- 9From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedAdaptation to hypoxia is an essential cellular response controlled by the oxygen-sensitive master transcription factor hypoxia-inducible factor 1 (HIF-1). HIF-1 expression is also controlled by specific microRNAs and,...
- 10From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedKRAS is one of the most frequently mutated human oncogenes. In some settings, oncogenic KRAS can trigger cellular senescence, whereas in others it produces hyperproliferation. Elucidating the mechanisms regulating these...
- 11From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedNeutrophils responsive to endogenous IFN-[beta] regulate tumor angiogenesis and growth in a mouse tumor model Jadwiga Jablonska, Sara Leschner, Kathrin Westphal, Stefan Lienenklaus, and Siegfried Weiss Original...
- 12From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedChronic kidney disease is a leading cause of death in the United States. Tubulointerstitial fibrosis (TIF) is considered the final common pathway leading to end-stage renal disease (ESRD). Here, we used pharmacologic,...
- 13From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedSpecialized peripheral sensory neurons known as nociceptors alert us to potentially damaging stimuli at the skin by detecting extremes in temperature and pressure and injury-related chemicals, and transducing these...
- 14From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-Reviewed[CD8.sup.+] T cells play a critical role in the immune response to viral pathogens. Persistent human cytomegalovirus (HCMV) infection results in a strong increase in the number of virus-specific, quiescent effector-type...
- 15From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedFanconi anemia (FA) is a genomic instability disorder characterized by bone marrow failure and cancer predisposition. FA is caused by mutations in any one of several genes that encode proteins cooperating in a repair...
- 16From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedSphingosine-1-phosphate (S1P) is a biologically active sphingolipid that has pleiotropic effects in a variety of cell types including ECs, SMCs, and macrophages, all of which are central to the development of...
- 17From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedThe excessive hepatic gluconeogenesis that occurs in insulin-resistant individuals is a key factor in their development of hyperglycemia and progression to type 2 diabetes mellitus. Recent in vitro data indicate that...
- 18From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedDuring embryo implantation and initiation of pregnancy, uterineNK(uNK) cells engage invasive fetal trophoblasts to remodel vessels that conduct blood to the placenta. This partnership, involving uNK cell receptors that...
- 19From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedIn clinical trials, aldosterone antagonists reduce cardiovascular ischemia and mortality by unknown mechanisms. Aldosterone is a steroid hormone that signals through renal mineralocorticoid receptors (MRs) to regulate...
- 20From: Journal of Clinical Investigation. (Vol. 120, Issue 11) Peer-ReviewedSince modern brain imaging of pain began 20 years ago, networks in the brain related to pain processing and those related to different types of pain modulation, including placebo, have been identified. Functional and...