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- 1From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedSkeletal muscle damaged by injury or by degenerative diseases such as muscular dystrophy is able to regenerate new muscle fibers. Regeneration mainly depends upon satellite cells, myogenic progenitors localized between...
- 2From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedCancer stem cells (CSCs) are a subpopulation of tumor cells that selectively possess tumor initiation and self-renewal capacity and the ability to give rise to bulk populations of nontumorigenic cancer cell progeny...
- 3From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedThe traditional view is that cancer cells predominately produce ATP by glycolysis, rather than by oxidation of energy-providing substrates. Mitochondrial uncoupling--the continuing reduction of oxygen without ATP...
- 4From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedTuberous sclerosis complex (TSC) is a dominantly inherited disease that is characterized by the growth of multiple benign tumors that are often difficult to treat. TSC is caused by mutations that inactivate the TSC1 or...
- 5From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedCD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of...
- 6From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedDirected gene transfer into specific cell lineages in vivo is an attractive approach for both modulating gene expression and correcting inherited mutations such as emphysema caused by human [alpha]1 antitrypsin (hAAT)...
- 7From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedGap junctions form electrical conduits between adjacent myocardial cells, permitting rapid spatial passage of the excitation current essential to each heartbeat. Arrhythmogenic decreases in gap junction coupling are a...
- 8From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedThe receptor tyrosine kinase/PI3K/AKT/mammalian target of rapamycin (RTK/PI3K/AKT/mTOR) pathway is frequently altered in cancer, but the underlying mechanism leading to tumorigenesis by activated mTOR remains less...
- 9From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedTumor hypoxia is a common microenvironmental factor that adversely influences tumor phenotype and treatment response. Cellular adaptation to hypoxia occurs through multiple mechanisms, including activation of the...
- 10From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedThe E3 ubiquitin ligase human murine double minute (HDM2) is overexpressed in 40%-80% of late-stage metastatic cancers in the absence of gene amplification. Hdm2 regulates p53 stability via ubiquitination and has also...
- 11From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedStem cell-based approaches have received much hype as potential treatments for neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in animal models of neurodegenerative diseases can...
- 12From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedA key event in the development of type 2 diabetes is pancreatic [beta] cell failure, one component of which is reduction in [beta] cell mass. ER stress is thought to contribute to [beta] cell failure, largely through...
- 13From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedEnabling stem cell-targeted therapies requires an understanding of how to create local microenvironments (niches) that stimulate endogenous stem cells or serve as a platform to receive and guide the integration of...
- 14From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedImmunity to infections relies on clonal expansion of [CD8.sup.+] T cells, their maintenance as effector CTLs, and their selection into a memory population. These processes rely on delivery of survival signals to...
- 15From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedThe regular articles and technical advances published in this issue are an average of 9,050 words, with 8.4 display items (figures and tables). Do we always need so many words to convey a message? We think not. With...
- 16From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedThe regulation of arterial contractility is essential for blood pressure control. The GTPase RhoA promotes vasoconstriction by modulating the cytoskeleton of vascular smooth muscle cells. Whether other Rho/Rac pathways...
- 17From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedVoltage-dependent sodium channels are the central players in the excitability of neurons, cardiac muscle, and skeletal muscle. Hundreds of mutations in sodium channels have been associated with human disease,...
- 18From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedOver the last decade, a remarkable number of papers have been published in which the biology of stem cells is introduced with words and phrases such as "promise," "rapid progress," and "future therapies." To separate...
- 19From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedStephen C. Benoit, Christopher J. Kemp, Carol F. Elias, William Abplanalp, James P. Herman, Stephanie Migrenne, Anne-Laure Lefevre, Celine Cruciani-Guglielmacci, Christophe Magnan, Fang Yu, Kevin Niswender, Boman G....
- 20From: Journal of Clinical Investigation. (Vol. 120, Issue 1) Peer-ReviewedMutations in either of the genes encoding the tuberous sclerosis complex (TSC), TSC1 and TSC2, result in a multisystem tumor disorder characterized by lesions with unusual lineage expression patterns. How these unusual...