Showing Results for
- Academic Journals (16)
Search Results
- 16
Academic Journals
- 16
- Search Terms:
- 1From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedTuberins, the tumor-suppressor proteins that regulate signaling via the kinase mTOR, now emerge as essential enforcers of T cell quiescence that promote survival. To meet the array of potential but unpredictable...
- 2From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedIn response to stimulation with proinflammatory cytokines, the deubiquitinase A20 inducibly interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin-editing complex. However, the...
- 3From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedThe kinase IKK[alpha] has a well-described activating role in the noncanonical transcription factor NF-[kappa]B pathway. Evidence now suggests that Ikk[alpha] also inhibits the canonical NF-[kappa]B pathway by...
- 4From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedTwo competing theories have been put forward to explain the role of [CD4.sup.+] T cells in priming [CD8.sup.+] memory T cells: one proposes paracrine secretion of interleukin 2 (IL-2); the other proposes the activation...
- 5From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedRegulatory T cells ([T.sub.reg] cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell ([T.sub.eff] cell) function and gain of suppressive activity by [T.sub.reg] cells are dependent on...
- 6From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedIn addition to its recognized function as an enzyme that catalyzes tryptophan, indoleamine 2,3-dioxygenase (IDO) acts as an intracellular signal transducer, in response to transforming growth factor-[beta] (TGF-[beta]),...
- 7From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedThe most potent foreign antigens for natural killer T cells (NKT cells) are [alpha]-linked glycolipids, whereas NKT cell self-reactivity involves weaker recognition of structurally distinct [beta]-linked glycolipid...
- 8From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedInterleukin 17 (IL-17) promotes the expression of chemokines and cytokines via the induction of gene transcription and post-transcriptional stabilization of mRNA. We show here that IL-17 enhanced the stability of...
- 9From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedLittle is known about the molecular mechanisms that determine the entry into the lymph node and intranodal positioning of lymph-derived cells. By injecting cells directly into afferent lymph vessels of popliteal lymph...
- 10From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedThe mechanisms that regulate T cell quiescence are poorly understood. We report that the tumor suppressor Tsc1 established a quiescence program in naive T cells by controlling cell size, cell cycle entry and responses...
- 11From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedProinflammatory signaling by the interleukin 17 receptor requires the adaptor Act1. Two studies identify an additional function for Act1 and identify new participants that regulate the inflammatory effects of IL-17....
- 12From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedIn plants and animals, the NLR family of receptors perceives non-self and modified-self molecules inside host cells and mediates innate immune responses to microbial pathogens. Despite their similar biological functions...
- 13From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedRegulation of tryptophan metabolism by indoleamine 2,3-dioxygenase (IDO) in dendritic cells (DCs) is a highly versatile modulator of immunity. In inflammation, interferon-[gamma] is the main inducer of IDO for the...
- 14From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedInterleukin 17 (IL-17) is critical in the pathogenesis of inflammatory and autoimmune diseases. Here we report that Act1, the key adaptor for the IL-17 receptor (IL-7R), formed a complex with the inducible kinase IKKi...
- 15From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedInterferon-[gamma] (IFN-[gamma]) has a critical role in immune responses to intracellular bacterial infection. MicroRNAs (miRNAs) are important in the regulation of innate and adaptive immunity. However, whether miRNAs...
- 16From: Nature Immunology. (Vol. 12, Issue 9) Peer-ReviewedAt the Toll2011 Meeting, recent advances in the field of innate immunity were presented and discussed. These insights have set new directions for both basic and translational research in this important field. At the...