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- 1From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedSara Ahmed, Donna G. Brickner, William H. Light, Ivelisse Cajigas, Michele McDonough, Alexander B. Froyshteter, Tom Volpe, Jason H. Brickner Nature Cell Biol. 12, 111-118 (2010); published online 24 January 2010;...
- 2From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedBone remodelling in vertebrates is coordinately regulated by the opposing effects of parathyroid hormone (PTH) and transforming growth factor-beta (TGF-[beta]). PTH couples the processes of bone resorption and formation...
- 3From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedSatellite cells are resident myogenic progenitors in postnatal skeletal muscle involved in muscle postnatal growth and adult regenerative capacity. Here, we identify and describe a population of muscle-resident stem...
- 4From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedThe dissemination of tumour cells to distant organs during metastasis requires an increase in cell survival. This has been shown to depend partly on deregulated expression of members of the inhibitors of apoptosis...
- 5From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedTransforming growth factor-[beta] (TGF-[beta]) induces epithelial--mesenchymal transdifferentiation (EMT) accompanied by cellular differentiation and migration (15). Despite extensive transcriptomic profiling, the...
- 6From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedThe kinase Jnk1 is a central regulator of obesity associated with a high-fat diet. However, the organ in which Jnk1 functions to regulate this process had not been identified. Davis and colleagues now show that Jnk1...
- 7From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedParathyroid hormone (PTH) regulates calcium homeostasis and bone metabolism by activating PTH type I receptor (PTH1R). Here we show that transforming growth factor (TGF)-[beta] type II receptor (T[beta]RII) forms an...
- 8From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedMetaphase spindles are highly dynamic structures, and have a higher concentration of microtubules than the surrounding cytoplasm. Spindle microtubules have been proposed to be stabilized by the local environment, for...
- 9From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedThe Notch signalling pathway has a crucial function in determining cell fates in multiple tissues within metazoan organisms (1). On binding to ligands, the Notch receptor is cleaved proteolytically and releases its...
- 10From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedHardly a day goes by without hearing the word 'globalization', used in one context or another. Whereas business and technology are widely recognized to be global undertakings, scientific research is not often discussed...
- 11From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedToxic aggregate-prone proteins, invading microorganisms and damaged organelles are cleared from the cytoplasm by autophagy, a process that involves their engulfment by a double-membrane phagophore that elongates and...
- 12From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedThe epidermal growth factor receptor (EGFR) is a critical determinator of cell fate. Signalling from this receptor tyrosine kinase is spatially regulated by progression through the endocytic pathway, governing receptor...
- 13From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedThe peroxisomal protein import machinery differs fundamentally from known translocons (endoplasmic reticulum, mitochondria, chloroplasts, bacteria) as it allows membrane passage of folded, even oligomerized proteins...
- 14From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedWe are becoming more and more aware of the almost ubiquitous involvement of microRNAs in shaping cellular properties. Several microRNAs influence steps involved in metastasis, including EMT, the name given to the...
- 15From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedMatthew S. Rodeheffer Nature Cell Biol. 12, 102-104 (2010); published online 17 January 2010; corrected after print, 21 January 2010 In the version of this News and Views initially published, cells are incorrectly...
- 16From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedMicroRNAs (miRNAs) are increasingly implicated in regulating the malignant progression of cancer. Here we show that miR-9, which is upregulated in breast cancer cells, directly targets CDH1, the E-cadherin-encoding...
- 17From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedPeroxisomes have always been the bad boys of the organelles, not following conventions and doing things their own way. They can grow and divide just like mitochondria and chloroplasts, but they can also be made de novo...
- 18From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedSilencing of individual genes can occur by genetic and epigenetic processes during carcinogenesis, but the underlying mechanisms remain unclear. By creating an integrated prostate cancer epigenome map using tiling...
- 19From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedFor most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal cell carcinoma (BCC), which is one of the most frequently...
- 20From: Nature Cell Biology. (Vol. 12, Issue 3) Peer-ReviewedI come from the north, from the periphery of Europe--Finland. I studied medicine in Helsinki, but actually I wanted to do research and first I tried clinical research. A classical area of Finnish medicine was vitamin...