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- 1From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedMost fast-acting neurotransmitters are rapidly cleared from synaptic regions. This feature isolates synaptic sites, rendering the time course of synaptic responses independent of the number of active synapses. We found...
- 2From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedIt has been suggested that ephrin-B proteins have receptor-like roles in the control of axon pathfinding by repulsion, although it is largely unknown how the reverse signals are coupled to downstream intracellular...
- 3From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedAnimal studies have shown that fear memories can change when recalled, a process referred to as reconsolidation. We found that oral administration of the β-adrenergic receptor antagonist propranolol before memory...
- 4From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedIn December, CNN announced that it would cut its entire science, technology and environmental news staff. There have also been deep job cuts elsewhere in the news industry, with established newspapers such as The New...
- 5From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedThe learning of new skills is characterized by an initial phase of rapid improvement in performance and a phase of more gradual improvements as skills are automatized and performance asymptotes. Using in vivo striatal...
- 6From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedPopulation coding is widely regarded as an important mechanism for achieving reliable behavioral responses despite neuronal variability. However, standard reinforcement learning slows down with increasing population...
- 7From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedNeurons are continuously generated from stem cells in discrete regions in the adult mammalian brain. We found that ependymal cells lining the lateral ventricles were quiescent and did not contribute to adult neurogenesis...
- 8From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedThe identity of neural stem cells (NSCs) responsible for lifelong neurogenesis in the rodent olfactory bulb has been hotly debated over the past decade. New olfactory bulb neurons originate from a region adjacent to the...
- 9From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedThe glucocorticoid receptor is a ubiquitous transcription factor mediating adaptation to environmental challenges and stress. Selective Nr3c1 (the glucocorticoid receptor gene) ablation in mouse dopaminoceptive neurons...
- 10From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedContradicting the common assumption that accurate recognition reflects explicit-memory processing, we provide evidence for recognition lacking two hallmark explicit-memory features: awareness of memory retrieval and...
- 11From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedThe neurodevelopmental disorder Rett syndrome (RTT) is caused by sporadic mutations in the transcriptional factor methyl-CpG-binding protein 2 (MeCP2). Although it is thought that the primary cause of RTT is cell...
- 12From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedDaytime vision is mediated by retinal cones, which, unlike rods, remain functional even in bright light and dark-adapt rapidly. These cone properties are enabled by rapid regeneration of their pigment. This in turn...
- 13From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedRett syndrome (RTT) is caused by mutations in the X-linked gene encoding methyl CpG-binding protein (MeCP2). The loss of MeCP2 function in neurons was thought to cause the disease. A study now challenges this assumption...
- 14From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedStudying gene expression provides a powerful means of understanding structure-function relationships in the nervous system. The availability of genome-scale in situ hybridization datasets enables new possibilities for...
- 15From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedHow active membrane conductance dynamics tunes neurons for specific time-varying stimuli remains poorly understood. We studied the biophysical mechanisms by which spike frequency adaptation shapes visual stimulus...
- 16From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-Reviewed
Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.
Maternal care influences hypothalamic-pituitary-adrenal (HPA) function in the rat through epigenetic programming of glucocorticoid receptor expression. In humans, childhood abuse alters HPA stress responses and increases... - 17From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedAlthough the properties and trafficking of AMPA-type glutamate receptors (AMPARs) depend critically on associated transmembrane AMPAR regulatory proteins (TARPs) such as stargazin (γ-2), no TARP has been described that...
- 18From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedCone photoreceptors distinguish small changes in light intensity while operating over a wide dynamic range. The cone synapse encodes intensity by modulating tonic neurotransmitter release, but precise encoding is limited...
- 19From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedCan we decode a person's brain activity to determine what that person is perceiving? Interest in this question has recently surged as a result of the success and popularity of applying multivariate classification...
- 20From: Nature Neuroscience. (Vol. 12, Issue 3) Peer-ReviewedIn the visual system of the blowfly Calliphora vicina, neurons of the vertical system (VS cells) integrate wide-field motion information from a retinotopic array of local motion detectors. In vivo calcium imaging reveals...