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- 1From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Wanping Xu [1, 3]; Xitong Yuan [1, 3]; Zhexin Xiang [2]; Edward Mimnaugh [1]; Monica Marcu [1]; Len Neckers (corresponding author) [1] The 90-kDa heat shock protein (Hsp90) is a molecular chaperone that...
- 2From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedThe latest in the fight over the teaching of evolution in classrooms across America is taking place in Pennsylvania, but local and state school boards in Maryland, Georgia, Ohio, Missouri, South Carolina and Kansas have...
- 3From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Koichi Fukuda [1]; Teresa Doggett [2, 4]; Ian J Laurenzi [3, 4]; Robert C Liddington (corresponding author) [1]; Thomas G Diacovo (corresponding author) [2] The ability of platelets to tether transiently to...
- 4From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Zhe Chen [1]; William D Singer [2]; Paul C Sternweis [2]; Stephen R Sprang (corresponding author) [1, 3] The GEF for Rho, p115RhoGEF [1, 2], is a potential regulatory link between G protein-coupled receptors...
- 5From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Wei Liu [1]; Jennifer Lippincott-Schwartz [1] Within eukaryotic cells, membrane-based transport carriers play a central role in the directed movement of proteins between intracellular compartments as well as...
- 6From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Christopher D Lima [1] Coordinated recruitment of RNA processing factors to RNA polymerase II (RNAPII) at the site of transcription ensures that nascent mRNA is processed into mature mRNA. The CTD of the...
- 7From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): G Brett Robb [1]; Kirk M Brown [1]; Jaspreet Khurana [1]; Tariq M Rana (corresponding author) [1] RNAi is the process by which a [similar]21-nucleotide (nt) double-stranded siRNA induces the cleavage and...
- 8From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): JJ L Miranda [1]; Peter De Wulf [2]; Peter K Sorger [2, 3]; Stephen C Harrison (corresponding author) [4] Chromosome segregation requires the attachment of spindle microtubules (MTs) to kinetochores,...
- 9From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Bryan M Turner [1] In 1977 Klug and colleagues published a structure [1] of the nucleosome core particle based on X-ray crystallographic analysis. It was and remains a thing of beauty and wonder. The...
- 10From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Ken Sato (corresponding author) [1, 2]; Akihiko Nakano [1, 3] In eukaryotic cells, intracellular protein transport between organelles of the secretory pathway is mediated by vesicles that are released from a...
- 11From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Satyajit Mayor [1] Fertilization is the process by which a sperm and an egg unite to form the first cell in the development of a multicellular organism. In mammals, the membrane properties of a viable and...
- 12From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Eric R Goedken [1, 2]; Steven L Kazmirski [1, 2]; Gregory D Bowman [1, 2]; Mike O'Donnell [3]; John Kuriyan (corresponding author) [1, 2] Sliding DNA clamps are essential, structurally conserved proteins...
- 13From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Todd Burckin [1, 6]; Roland Nagel [1, 2, 6]; Yael Mandel-Gutfreund [1, 2, 5]; Lily Shiue [3]; Tyson A Clark [1, 5]; Jean-Leon Chong [4]; Tien-Hsien Chang [4]; Sharon Squazzo [1]; Grant Hartzog [1, 3]; Manuel...
- 14From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Michelle D Edwards [1, 4]; Yuezhou Li [2, 4]; Sanguk Kim [3, 4]; Samantha Miller [1]; Wendy Bartlett [1]; Susan Black [1]; Sally Dennison [1]; Irene Iscla [2]; Paul Blount [2]; James U Bowie [3]; Ian R Booth...
- 15From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Satoko Yoshizawa (corresponding author) [1]; Linda Rasubala [2]; Toyoyuki Ose [2]; Daisuke Kohda [2]; Dominique Fourmy [1]; Katsumi Maenaka (corresponding author) [2] Selenium, an essential trace element, is...
- 16From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedShaken, not stirred The pathology of several neurodegenerative diseases involves the accumulation of ordered protein aggregates called amyloid fibrils. These self-assembled filaments are characterized by a high...
- 17From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Alexandra Lusser [1, 2]; Debra L Urwin [1]; James T Kadonaga (corresponding author) [1] The packaging of DNA into chromatin is a critical step in the organization and utilization of the genome. In this...
- 18From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): HoaAnh Nguyen [1, 2, 3]; Hideo Higuchi (corresponding author) [1, 3] Calcium regulates various enzyme reactions of cellular processes through direct interaction to modify the function of a protein or through...
- 19From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Boris Martinac [1] Mechanical forces act on living organisms from all directions throughout the biosphere, making mechanosensory transduction one of the fundamental sensory transduction processes in the...
- 20From: Nature Structural and Molecular Biology. (Vol. 12, Issue 2) Peer-ReviewedAuthor(s): Christian G Noble [1, 5]; David Hollingworth [2, 5]; Stephen R Martin [3]; Valerie Ennis-Adeniran [1]; Stephen J Smerdon [1]; Geoff Kelly [4]; Ian A Taylor (corresponding author) [1]; Andres Ramos...