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- 1From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedTo identify transcriptional profiles predictive of the clinical benefit of cisplatin and fluorouracil (CF) chemotherapy to gastric cancer patients, endoscopic biopsy samples from 96 CF-treated metastatic gastric cancer...
- 2From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedAntipsychotic-induced weight gain has emerged as a serious complication in the treatment of patients with most antipsychotics. We have conducted the first in-depth examination of dopamine receptor genes in...
- 3From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedStevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare but severe, potentially life threatening adverse drug reactions characterized by skin blistering. Previous studies have identified...
- 4From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedJ Miao, Y Jin, RL Marunde, CJ Gorski, S Kim, S Quinney, M Radovich, L Li and SD Hall Correction to: The Pharmacogenomics Journal (2009) 9, 319-326;doi:10.1038/ tpj.2009.21;published online 9 June 2009 The list of...
- 5From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedMany pharmacogenetic studies fail to yield any statistically significant associations. Such negative findings may be due to the absence of, or inadequate statistical power to test for, an effect at the genetic variants...
- 6From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedWhole-genome association studies in rheumatoid arthritis have identified single-nucleotide polymorphisms (SNPs) predisposing to disease with moderate risk. We aimed to investigate the role of these markers in predicting...
- 7From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedQT prolongation is associated with increased risk of cardiac arrhythmias. Identifying the genetic variants that mediate antipsychotic-induced prolongation may help to minimize this risk, which might prevent the removal...
- 8From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedOften, analysis for pharmacogenomic studies involving multiple drugs from the same class is completed by analyzing each drug individually for association with genomic variation. However, by completing the analysis of...
- 9From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedCYP2D6 polymorphism is associated with variability in drug response, endogenous metabolism (that is, serotonin), personality, neurocognition and psychopathology. The relationship between CYP2D6 genetic polymorphism and...
- 10From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedInterferon-[beta] (IFN-[beta]) is one of the major drugs for multiple sclerosis (MS) treatment. The purpose of this study was to characterize the transcriptional effects induced by intramuscular IFN-[beta]-1a therapy in...
- 11From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedCYP2D6 genotype and debrisoquine metabolic ratio (MR) were analyzed in 133 Nicaraguan Mestizos (NMs) and 260 Cubans divided into Cuban Mestizos (CMs) and White Cubans (WCs). The frequencies of poor metabolizers (MR...
- 12From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedPharmacogenomics is yet to fulfill its promise of manifestly altering clinical medicine. As one example, a predictive test for tardive dyskinesia (TD) (an adverse drug reaction consequent to antipsychotic exposure)...
- 13From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedOverexpression of the multi-drug transporter P-glycoprotein, encoded by the ABCB1 gene, is a clinically relevant problem in acute myeloid leukemia (AML). Polymorphisms in ABCB1 might contribute to cancer risk and...
- 14From: The Pharmacogenomics Journal. (Vol. 12, Issue 2) Peer-ReviewedY-R Liu, E-W Loh, T-H Lan, S-F Chen, Y-H Yu, Y-H Chang, C-J Huang, T-M Hu, K-M Lin, Y-T Yao and H-J Chiu Correction to: The Pharmacogenomics Journal (2010) 10: 30-39;doi: 10.1038/ tpj.2009.55; published online 17...