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- 1From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedParkinson's disease is the most common neurodegenerative movement disorder. Mutations in PINK1 and PARKIN are the most frequent causes of recessive Parkinson's disease. However, their molecular contribution to...
- 2From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedRotational movement of the node cilia generates a leftward fluid flow in the mouse embryo (1) because the cilia are posteriorly tilted (2,3). However, it is not known how anterior-posterior information is translated...
- 3From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedSkeletal muscle has exceptional regenerative capacity, capable of numerous rounds of rapid repair in response to injury (1). The ectopic development of adipocytes and increased scar tissue formation (fibrosis) in...
- 4From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedThe pathogenesis of Parkinson's disease (PD) is characterized by substantial loss of dopamine-containing neuronal cells and the formation of cytoplasmic inclusions (Lewy bodies) that accommodate aggregation-prone...
- 5From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedFaithful chromosome segregation depends on the microtubule attachment and biorientation of kinetochores, a process monitored by the spindle checkpoint. Aurora B and protein phosphatase 1 (PP1) have opposing roles in...
- 6From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedDNA double-strand breaks (DSBs) trigger ATM (ataxia telangiectasia mutated) signalling and elicit genomic rearrangements and chromosomal fragmentation if misrepaired or unrepaired. Although most DSB repair is...
- 7From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedThe mammalian target of rapamycin (mTOR) forms two distinct multi-protein signalling complexes: TORC1 and TORC2. TORC1 has a defined role in several neurobiological processes, but the function of TORC2 in neurons is...
- 8From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedEfficient tissue regeneration is dependent on the coordinated responses of multiple cell types. Here, we describe a new subpopulation of fibro/adipogenic progenitors (FAPs) resident in muscle tissue but arising from a...
- 9From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedScientific research involves teams composed of graduate students, postdoctoral fellows, technicians and undergraduate students working on various defined aspects of a larger question. Mentoring, defined here as...
- 10From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedHedgehog signalling is crucial for development and is deregulated in several tumours, including medulloblastoma. Regulation of the transcriptional activity of Gli (glioma-associated oncogene) proteins, effectors of the...
- 11From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedThe ties holding sister chromatids together during mitosis must be sufficiently strong to provide counter tension to the pulling forces of microtubules attached to their kinetochores. This molecular tension begins...
- 12From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedMany genes in Saccharomyces cerevisiae are recruited to the nuclear periphery after transcriptional activation. We have identified two gene recruitment sequences (GRS I and II) from the promoter of the INO1 gene that...
- 13From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedKaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several acquired immune deficiency syndrome-related malignancies, including Kaposi's sarcoma, primary effusion lymphoma (PEL) and a subset of...
- 14From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedJeremy T. Smyth, John G. Petranka, Rebecca R. Boyles, Wayne I. DeHaven, Miwako Fukushima, Katina L. Johnson (2), Jason G. Williams (2) and James W. Putney Jr Nature Cell Biol. 11, 1465-1472 (2009); published online 1...
- 15From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedThe metaphase-anaphase transition is orchestrated through proteolysis of numerous proteins by a ubiquitin protein ligase called the anaphase-promoting complex or cyclosome (APC/C) (1). A crucial aspect of this process...
- 16From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedThe RanGTP gradient surrounding chromosomes drives mitotic spindle assembly by allowing the local release of several factors from the importin-[alpha]/[beta] heterodimer, including microtubule regulators. Eric Karsenti...
- 17From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedEctopic fat deposition in skeletal muscle is closely associated with several disorders, however, the origin of these adipocytes is not clear, nor is the mechanism of their formation. Satellite cells function as adult...
- 18From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedThe transmembrane Wnt receptors of the low density lipoprotein receptor-related protein (LRP) family are activated via phosphorylation of multiple conserved motifs within their intracellular domain. Niehrs and...
- 19From: Nature Cell Biology. (Vol. 12, Issue 2) Peer-ReviewedThe metazoan nuclear pore complex (NPC) disassembles during mitosis, and many of its constituents distribute onto spindles and kinetochores, including the Nup107-160 subcomplex (1,2). We have found that Nup107-160...