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- 1From: Critical Care. (Vol. 12, Issue Suppl 1) Peer-ReviewedIntroduction This study pools data from the UK Intensive Care National Audit and Research Center (ICNARC) Case Mix Programme (CMP) to evaluate the case mix, outcome and activity for 17,326 patients with severe acute...
- 2From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction Administrative coding of medical diagnoses in intensive care unit (ICU) patients is mandatory in order to create databases for use in epidemiological and economic studies. We assessed the reliability of...
- 3From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction Gelsolin is an actin-binding plasma protein that is part of an 'actin-scavenging' system. Studies suggest that plasma gelsolin may play a crucial role in the pathophysiology of sepsis. Little is known...
- 4From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction Lung fibrosis, reduced lung compliance, and severe hypoxemia found in patients with acute lung injury often result in a need for the support of mechanical ventilation. High-tidal-volume mechanical...
- 5From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction Circulatory dysfunction in cirrhotic patients may cause a specific kind of functional renal failure termed hepato-renal syndrome (HRS). It contributes to the high incidence of renal failure in cirrhotic...
- 6From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction To systematically review studies evaluating the performance of Sequential Organ Failure Assessment (SOFA)-based models for predicting mortality in patients in the intensive care unit (ICU). Methods...
- 7From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction This prospective observational study was conducted to describe the nature of the intensive care population across Ireland, identify adherence to international benchmarks of practice, and describe patient...
- 8From: Critical Care. (Vol. 12) Peer-ReviewedBackground Severe traumatic brain injury (TBI) has been increasing with greater incidence of injuries from traffic or sporting accidents. Although there are a number of animal models of TBI using progesterone for...
- 9From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction Anticoagulant therapy attracts much attention for the treatment of severe sepsis since recent studies have revealed that some anticoagulants have the ability to regulate the inflammatory response. The...
- 10From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction The high cost of critical care resources has resulted in strategies to reduce the costs of ruling out low-risk patients by developing intermediate care units (IMCs). The aim of this study was to compare...
- 11From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction The paucity of data on resource use in critically ill patients with hematological malignancy and on these patients' perceived poor outcome can lead to uncertainty over the extent to which intensive care...
- 12From: Critical Care. (Vol. 12) Peer-ReviewedIntoduction Clearance of alveolar oedema depends on active transport of sodium across the alveolar-epithelial barrier. [beta]-Adrenergic agonists increase clearance of pulmonary oedema, but it has not been...
- 13From: Critical Care. (Vol. 12) Peer-ReviewedBackground Pain in critically ill patients in the intensive care unit (ICU) is common. However, pain assessment in critically ill patients often is complicated because these patients are unable to communicate...
- 14From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction The relationship between brain natriuretic peptide (BNP) increase in acute pulmonary embolism (PE) and the increase in mortality and morbidity has frequently been suggested in small studies but its...
- 15From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction One of the greatest problems with continuous renal replacement therapy (CRRT) is early coagulation of the filters. Few studies have monitored circuit function prospectively. The purpose of this study was...
- 16From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction The purpose of this review was to evaluate the impact of corticosteroids on the outcomes of patients with severe community-acquired pneumonia (CAP). Methods We performed a systematic MEDLINE,...
- 17From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction The rate of weaning of vasopressors drugs is usually an empirical choice made by the treating in critically ill patients. We applied fuzzy logic principles to modify intravenous norepinephrine...
- 18From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction Little is known about the mechanisms through which intensivist physician staffing influences patient outcomes. We aimed to assess the effect of closed-model intensive care on evidence-based ventilatory...
- 19From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction The endothelial specific angiopoietin (Ang)-Tie2 ligand-receptor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis. Binding of circulating Ang-1 to...
- 20From: Critical Care. (Vol. 12) Peer-ReviewedIntroduction End expiratory lung volume (EELV) measurement in the clinical setting is routinely performed using the helium dilution technique. A ventilator that implements a simplified version of the nitrogen...