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- 1From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedChanges in chromatin structure are a conserved hallmark of ageing, and the mechanism driving these changes, as well as their functional significance, are heavily investigated. Loss of core histones is now observed in...
- 2From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedEndothelial cells establish an instructive vascular niche that reconstitutes haematopoietic stem and progenitor cells (HSPCs) through release of specific paracrine growth factors, known as angiocrine factors. However,...
- 3From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedThe Rho-like GTPase, Rac1, induces cytoskeletal rearrangements required for cell migration. Rac activation is regulated through a number of mechanisms, including control of nucleotide exchange and hydrolysis, regulation...
- 4From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedThe Polycomb group (PcG) protein, enhancer of zeste homologue 2 (EZH2), has an essential role in promoting histone H3 lysine 27 trimethylation (H3K27me3) and epigenetic gene silencing (1-4). This function of EZH2 is...
- 5From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedCells can divide asymmetrically, giving daughter cells that have distinct fates. In many cells asymmetrical division is determined by the positioning of the mitotic spindle, which is pulled towards one end of the cell....
- 6From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedHomeostasis in the mammalian intestinal epithelium relies on the presence of a fixed number of stem cells with self-renewing capacity and the ability to generate progenitors that differentiate into the various cell...
- 7From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedIron is an essential element in many biological processes. In vertebrates, serum transferrin is the major supplier of iron to tissues, but the function of additional transferrin-like proteins remains poorly understood....
- 8From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedOur bodies have developed multiple systems to respond to many different types of mechanical stimuli. When a person shouts from across a room, the sound waves bend the stereocilia on the surface of hair cells in the...
- 9From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedDiverse intracellular pathogens subvert the host actinpolymerization machinery to drive movement within and between cells during infection. Rickettsia in the spotted fever group (SFG) are Gram-negative, obligate...
- 10From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedS-nitrosylation of proteins by nitric oxide is a major mode of signalling in cells (1). S-nitrosylation can mediate the regulation of a range of proteins, including prominent nuclear proteins, such as HDAC2 (ref. 2) and...
- 11From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedStringent control of the events at the kinetochore-microtubule interface is critical for faithful chromosome segregation. Compton and colleagues now report how a switch in CLASP1-binding partners at the outer...
- 12From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedMicrotubule nucleation in interphase plant cells primarily occurs through branching from pre-existing microtubules at dispersed sites in the cell cortex (1,2,3). The minus ends of new microtubules are often released...
- 13From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedTo form epithelial organs cells must polarize and generate de novo an apical domain and lumen. Epithelial polarization is regulated by polarity complexes that are hypothesized to direct downstream events, such as...
- 14From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedThe contribution and order of polarity complexes and vesicular trafficking events during lumen formation remains obscure. Now, lumenogenesis in MDCK cell cysts is shown to require a Rab11a-Rabin8-Rab8a network that...
- 15From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedSandie Tuduri, Laure Crabbe, Chiara Conti, Helene Tourriere, Heidi Holtgreve-Grez, Anna Jauch, Veronique Pantesco, John De Vos, Aubin Thomas, Charles Theillet, Yves Pommier, Jamal Tazi, Arnaud Coquelle and Philippe...
- 16From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedProtein S-nitrosylation is thought to be mediated primarily by nitric oxide synthases. S-nitrosylated GAPDH is now shown to function within signal transduction cascades as a nuclear nitrosylase. Along with other recent...
- 17From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedThe Aurora-A kinase (AurA) is essential for normal mitotic progression, but accumulating evidence suggests that it has important biological functions during interphase as well. However, the mechanism by which AurA is...
- 18From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedThe mTOR pathway is the central regulator of cell size (1). External signals from growth factors and nutrients converge on the mTORC1 multi-protein complex to modulate downstream targets, but how the different inputs...
- 19From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedUnlike mammals, teleost fish mount a robust regenerative response to retinal injury that culminates in restoration of visual function (1,2). This regenerative response relies on dedifferentiation of Muller glia into a...
- 20From: Nature Cell Biology. (Vol. 12, Issue 11) Peer-ReviewedThe initiation of DNA synthesis is governed by the licensing of replication origins, which consists of assembling a pre-replication complex (pre-RC) on origins during late M- and G1-phases (1,2). In metazoans,...