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- 1From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedChristopher Horvath, Laura Andrews, Andreas Baumann, Lauren Black, Diann Blanset, Joy Cavagnaro, Kenneth L. Hastings, David L. Hutto, Timothy K. MacLachlan, Mark Milton, Theresa Reynolds, Stan Roberts, Mark Rogge,...
- 2From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedCognate antigen recognition and inflammation are required to promote the activation and expansion of memory [CD8.sup.+] T cell populations. However, the exact contribution of each type of signal to the eventual...
- 3From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedThe natural human antibody response is a rich source of highly specific, neutralizing and self-tolerant therapeutic reagents. Recent advances have been made in isolating and characterizing monoclonal antibodies that are...
- 4From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedThis study provides evidence of a central role for the spleen in the induction of T cell tolerance in tumour-bearing hosts. In several tumour models, splenectomy fully restored the activation of tumour antigen-specific...
- 5From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedAutoreactive T cells are eliminated in the thymus by negative selection. By contrast, most autoreactive or polyreactive B cells are not deleted during their development but are kept in check through other mechanisms,...
- 6From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedObesity is associated with changes in the composition of the intestinal microbiota, but it remains unclear how dietary changes promote alterations in the microbiota. Reporting in Nature Immunology, Upadhyay et al. show...
- 7From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedSelf-tolerance is maintained by the negative selection of self-reactive T cells in the thymus and the generation of regulatory T ([T.sub.Reg]) cells to control self-reactive T cells in the periphery. How T cell receptor...
- 8From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedThe function of the gastrointestinal tract relies on a monolayer of epithelial cells, which are essential for the uptake of nutrients. The fragile lining requires protection against insults by a diverse array of...
- 9From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedAdipocyte progenitors are derived from mesenchymal stem cells and express the transmembrane marker PREF1 (also known as DLK1). Imaging of embryonic lymph nodes and their associated fat pads revealed the presence of...
- 10From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedChildren with an aggressive form of neuroblastoma have benefited from treatment with an antibody that targets the disialoganglioside surface antigen GD2. Natural killer (NK) cells are known to be important in the immune...
- 11From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedA new disease characterized by AIDS-like symptoms has been identified by researchers at the US National Institutes of Health (NIH). The good news is the disease is not contagious--it is caused by autoantibodies specific...
- 12From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedIn this study, the authors describe a multistep pathway for targeting Mycobacterium tuberculosis for autophagy. The M. tuberculosis type VII secretion system ESX1 was shown to permeabilize bacterium-containing...
- 13From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedIn their correspondence piece on my recently published Comment article (The storm has cleared: lessons from the CD28 superagonist TGN1412 trial. Nature Rev. Immunol. 12, 317-318 (2012)) (1), Horvath et al. (Storm...
- 14From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedReporting in Science Translational Medicine, Wang et al. describe a method to prospectively identify rare human melanoma-specific [CD8.sup.+] central memory T cells ([T.sub.CM] cells) based on cytokine production....
- 15From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedHIV targets [CD4.sup.+] T cells, but two studies now report an accumulation of [CD4.sup.+] T follicular helper ([T.sub.FH]) cells in humans and primates with chronic HIV and SIV infection, respectively. The relative...
- 16From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedThis letter is in response to the Comment article published in Nature Reviews Immunology by Thomas Hunig (The storm has cleared: lessons from the CD28 superagonist TGN1412 trial. Nature Rev. Immunol. 12, 317-318 (2012))...
- 17From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedThe pathogenesis of multiple sclerosis involves numerous steps, including the activation of autoreactive T cells, their migration through the blood-brain barrier and the development of inflammatory lesions in the...
- 18From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedProbiotics and prebiotics are increasingly being added to foodstuffs with claims of health benefits. Probiotics are live microorganisms that are thought to have beneficial effects on the host, whereas prebiotics are...
- 19From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedThe interaction of antigen-presenting cells with free peptides or a denatured protein can give rise to peptide-MHC class II complexes that are distinct from those generated after the processing of the whole protein....
- 20From: Nature Reviews Immunology. (Vol. 12, Issue 10) Peer-ReviewedNeutrophil extracellular traps (NETs) are fibrous networks of DNA and antimicrobial factors that are released by neutrophils to trap and kill pathogens. NETosis was thought to be associated with cell death, and thus it...