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- 1From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedTo better understand the mechanisms that regulate stem cell identity and function, we sought to identify genes that are preferentially expressed by stem cells and critical for their function in multiple tissues. Prdm16...
- 2From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedThe epithelial-mesenchymal transition (EMT) occurs in pre-metastatic cancer cells and is also associated with the acquisition of stem-cell-like characteristics. A molecular link between EMT and stemness now emerges with...
- 3From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedThe AP-1 transcription factor c-Jun is essential for cellular proliferation in many cell types, but the molecular link between growth factors and c-Jun activation has been enigmatic. In this study we identify a...
- 4From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedMin Wu, Bo Huang, Morven Graham, Andrea Raimondi, John E. Heuser, Xiaowei Zhuang and Pietro De Camilli Nat. Cell Biol. 12, 902-908 (2010); published online 22 August 2010; corrected after print, 26 August 2010 In...
- 5From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedMicroRNAs (miRNAs) are small (approximately 22 nucleotides) noncoding RNAs in plants and animals that direct post-transcriptional gene silencing by base pairing with complementary sites preferentially found in the 3'...
- 6From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedSprouting angiogenesis requires the coordinated behaviour of endothelial cells, regulated by Notch and vascular endothelial growth factor receptor (VEGFR) signalling. Here, we use computational modelling and genetic...
- 7From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedMammalian ageing is accompanied by accumulation of genomic DNA damage and progressive decline in the ability of tissues to regenerate (1). DNA damage activates the tumour suppressor p53, which leads to cell-cycle...
- 8From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedIt has been proposed that the spindle assembly checkpoint detects both unattached kinetochores and lack of tension between sister kinetochores when sister chromatids are not attached to opposite spindle poles. However,...
- 9From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedClathrin-independent endocytosis (CIE) is relatively understudied, compared with clathrin-mediated and caveolar endocytosis. Clathrin-independent carriers (CLICs) are known to bud from the plasma membrane in a...
- 10From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedEarlier this year, in an interview with a British newspaper, Paul Nurse, now the President of the Royal Society, touched a nerve within the science establishment in the UK when he called for a reform of research-funding...
- 11From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedIn the developing Drosophila wing epithelium, planar cell polarity (PCP) directs the orientation of hair outgrowth along the proximal-distal axis. Two new studies shed light on how tissue morphogenesis influences PCP....
- 12From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedIn the Saccharomyces cerevisiae pheromone-response pathway, the transcription factor Ste12 is inhibited by two mitogen-activated protein (MAP)-kinase-responsive regulators, Dig1 and Dig2. These two related proteins bind...
- 13From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedXue Han and Martin Srayko Nat. Cell Biol. 12, 849-851 (2010); published online 22 August 2010; corrected after print, 2 September 2010 In the version of this News and views article initially published online and...
- 14From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedThe [SCF.sup.Fbw7] ubiquitin ligase mediates growth-factor-regulated turnover of the Myc oncoprotein. Here we show that [SCF.sup.[beta]-TrCP] binds to Myc by means of a characteristic phosphodegron and ubiquitylates...
- 15From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedTranscriptional noise has an important role in generating diversity in cellular populations that are seemingly identical. As this noise stems from the inherent stochasticity of gene expression, it has been unclear...
- 16From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedStem cells reside in specialized microenvironments or 'niches' that regulate their function. In vitro studies using hypoxic culture conditions (< 5% [O.sub.2]) have revealed strong regulatory links between [O.sub.2]...
- 17From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedTo revise a common cliche: we are what we (and our cells) signal. Extracellular stimuli influence diverse intracellular signalling pathways to regulate gene transcription and guide cellular processes. An especially...
- 18From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedWe show that the transcriptional repressor Tel plays an evolutionarily conserved role in angiogenesis: it is indispensable for the sprouting of human endothelial cells and for normal development of the Danio rerio blood...
- 19From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedDouble strand breaks (DSB) in DNA need to be efficiently recognized and repaired to ensure genomic integrity. Although much is known about the cascade of ubiquitylation events triggered by DSBs, inhibitors of this...
- 20From: Nature Cell Biology. (Vol. 12, Issue 10) Peer-ReviewedIt was as a high-school teacher in Africa that I realized biology was my destiny. Science teachers were a rare commodity at the rural school in Kenya where I volunteered. There were no textbooks, so I simplified...