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- 1From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedMutations in the EFHC1 gene are linked to juvenile myoclonic epilepsy (JME), one of the most frequent forms of idiopathic generalized epilepsies. JME is associated with subtle alterations of cortical and subcortical...
- 2From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedThe amygdala plays key roles in emotion and social cognition, but how this translates to face-to-face interactions involving real people remains unknown. We found that an individual with complete amygdala lesions lacked...
- 3From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedNeuronal populations in sensory cortex represent time-changing sensory input through a spatiotemporal code. What are the rules that govern this code? We measured membrane potentials and spikes from neuronal populations...
- 4From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedReports of scientific misconduct often make for sensational media reports. High-profile cases of falsification inevitably call for a re-examination of whether and how fraud can be detected before publication. The growing...
- 5From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedThe detection of approaching objects, such as looming predators, is necessary for survival. Which neurons and circuits mediate this function? We combined genetic labeling of cell types, two-photon microscopy,...
- 6From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedMemory and the Computational Brain: Why Cognitive Science will Transform Neuroscience by C R Gallistel & Adam Philip King Wiley-Blackwell, 2009 336 pp, hardcover, $99.95 ISBN 1405122889 Along with a light...
- 7From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedFusion of synaptic vesicles upon calcium influx requires precise localization of voltage-gated calcium channels. A new study identifies a previously uncharacterized protein that mediates trafficking of [Ca.sub.V]2...
- 8From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedPavlovian trace conditioning depends on the temporal gap between the conditioned and unconditioned stimuli. It requires, in mammals, functional medial temporal lobe structures and, in humans, explicit knowledge of the...
- 9From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedCardiac arrest victims may experience transient brain hypoperfusion leading to delayed death of hippocampal CAI neurons and cognitive impairment. We prevented this in adult rats by inhibiting the expression of transient...
- 10From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedRecent human imaging work has expanded the view of amygdala function beyond early findings in animals, but two studies of an individual with bilateral amygdala damage now suggest that we should be thinking even more...
- 11From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedDynamic remodeling of spiny synapses is crucial for cortical circuit development, refinement and plasticity, whereas abnormal morphogenesis is associated with neuropsychiatric disorders. We found that activation of...
- 12From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedPresynaptic voltage-gated calcium channels provide calcium for synaptic vesicle exocytosis. We show here that a green fluorescent protein-tagged [α.sub.1] subunit of the Caenorhabditis elegans CaV2 channel, UNC-2, is...
- 13From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedAn important feature of the cerebral cortex is its layered organization, which is modulated in an area-specific manner. We found that the transcription factor AP2γ regulates laminar fate in a region-specific manner....
- 14From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedDuring the day, certain retinal ganglion cells respond specifically to dark, approaching stimuli. A study finds that the retinal circuit that gives rise to this response makes use of an amacrine cell that was previously...
- 15From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedSharp wave-ripple (SPW-R) complexes in the hippocampusentorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective...
- 16From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedThe amygdala is thought to process fear-related stimuli rapidly and nonconsciously. We found that an individual with complete bilateral amygdala lesions, who cannot recognize fear from faces, nonetheless showed normal...
- 17From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedNeural stem cells (NSCs) are controlled by diffusible factors. The transcription factor Sox2 is expressed by NSCs and Sox2 mutations in humans cause defects in the brain and, in particular, in the hippocampus. We deleted...
- 18From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedTopical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in...
- 19From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedTo determine whether entorhinal spatial representations are continuous or fragmented, we recorded neural activity in grid cells while rats ran through a stack of interconnected, zig-zagged compartments of equal shape and...
- 20From: Nature Neuroscience. (Vol. 12, Issue 10) Peer-ReviewedAstrocytes are critical participants in synapse development and function, but their role in synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to regulate neuron-glia interactions,...