Showing Results for
- Academic Journals (20)
Search Results
- 20
Academic Journals
- 20
- Search Terms:
- 1From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedIn all eukaryotes, the target of rapamycin (TOR) signalling pathway couples energy and nutrient abundance to the execution of cell growth and division, owing to the ability of TOR protein kinase to simultaneously sense...
- 2From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedThis study shows that, in addition to their role in degrading cell cycle proteins, atypical Lys11-linked ubiquitin chains might function in cell signalling. Receptor-interacting protein 1 (RIP1), which is involved in...
- 3From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedAutophagy not only recycles intracellular components to compensate for nutrient deprivation but also selectively eliminates organelles to regulate their number and maintain quality control. Mitophagy, the specific...
- 4From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedOrganisms must precisely regulate protein synthesis to tailor their response to environmental fluctuations. This regulation is complex and involves tight control at many levels, including transcription, mRNA decay and...
- 5From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedKnowing the subcellular localization of a protein is essential for understanding its function. When Stradal et al. discovered that the ABL1 (also known as c-Abl) binding partner ABL interactor (ABI) is dynamically...
- 6From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedThe N-end rule and ubiquitin fusion degradation (UFD) pathways are ubiquitin-dependent proteolytic systems in Saccharomyces cerevisiae. Ubiquitylation of protein substrates in the N-end rule pathway requires the E2...
- 7From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedPrimary mammalian cells undergo replicative senescence after repeated passage, and this is often associated with induction of the tumour suppressor p16 (also known as CDKN2A). To identify new regulators of p16...
- 8From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedPlasma membrane ATPases are primary active transporters of cations that maintain steep concentration gradients. The ion gradients and membrane potentials derived from them form the basis for a range of essential...
- 9From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedCompared with efforts to understand how the mitotic spindle is set up during metaphase, there has been relatively little emphasis on how it is removed at the end of cell division. By combining live-cell imaging and...
- 10From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedThe dynamic post-translational modification of proteins on Ser and Thr by [beta]-N-acetylglucosamine (O-GlcNAc) can regulate processes such as transcription and cell signalling. This study identifies histones as novel...
- 11From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedPluripotent stem cells can be derived from embryos or induced from adult cells by reprogramming. They are unique among stem cells in that they can give rise to all cell types of the body. Recent findings indicate that a...
- 12From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedTransforming growth factor-p (TGFP) activates receptors to phosphorylate SMAD2 and SMAD3, enabling them to form a complex with SMAD4. This complex coordinates SMAD-activated transcription until transcription is...
- 13From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedSome membrane proteins carry a specific sorting sequence that allows them to escape degradation when entering the endosome and to recycle back to the membrane. This was thought to be mediated by a uniform population of...
- 14From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedThe release of cytochrome c from mitochondria is crucial for apoptosis and is regulated by homo-oligomers of the pro-apoptotic proteins BAX and BCL-2 homologous antagonist or killer (BAK). It is not clear how activation...
- 15From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedMitochondria maintain genome and translation machinery to synthesize a small subset of subunits of the oxidative phosphorylation system. To build up functional enzymes, these organellar gene products must assemble with...
- 16From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedThe formation of multinucleated myotubes in Drosophila melanogaster involves fusion between mononucleated muscle founder cells and fusion-competent myoblasts (FCMs), and Sens et al. identify a new podosome-like...
- 17From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedMany of us could be forgiven for thinking that current schematics of focal adhesions accurately reflect their molecular organization. However, these diagrams are based mainly on results from protein-protein interaction...
- 18From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedThe Ser/Thr kinase LKB1 (also known as STK11) is essential for the maintenance of haematopoietic stem cell (HSC) homeostasis, according to three studies published in Nature. LKB1 regulates the metabolism of many...
- 19From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedSynthetic devices that translate molecular inputs into gene expression changes are valuable for manipulating cellular behaviour, but until now these circuits have been able to respond only to a limited set of inputs,...
- 20From: Nature Reviews Molecular Cell Biology. (Vol. 12, Issue 1) Peer-ReviewedMitochondria and chloroplasts import the vast majority of their proteins across two membranes, and use translocases of the outer membrane as an entry gate. These translocases interact with the incoming precursor protein...