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- Search Terms:ISSN: 14655411AndISSN: 1465542XAndVolume Number: 12AndIssue Number: 1AndStart Page: R11AndDate: 2010 Revise Search
- 1From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): PR Quinlan1 , A Ashfield1 , L Jordan2 , C Purdie2 and AM Thompson1 Tissue banks provide a core facility that enable translational research to be undertaken on quality-assured patient-donated samples. These...
- 2From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): CN Birts1 and JP Blaydes1 We are interested in finding novel therapeutic targets for breast cancer, particularly focusing on C-terminal binding proteins (CtBPs) as when they are inhibited, cells show an...
- 3From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): R Sainsbury1 , I Proctor1 , S Rodriguez1 , M Loddo1 , S Tudzarova1 , K Stoeber1 and G Williams1 Based on protein expression profiles of core regulatory proteins involved in the G1 -S and G2 -M phase...
- 4From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): JM Flanagan1,2 , S Kugler3 , N Waddell3 , CN Johnstone3 , A Marsh3 , S Henderson2 , P Simpson4 , L da Silva4 , K Khanna3 , S Lakhani4 , C Boshoff2 and G Chenevix-Trench3 It is now understood that...
- 5From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): MM Murray1 , N Buckley1 and DP Harkin1 The cancer stem cell hypothesis proposes that tumors contain a subset of stem or progenitor cells that are resistant to chemotherapy and have evaded the normally...
- 6From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): E Lamers1 , FA McDyer2 , JM Mulligan2 , F Couch3 , KI Savage1 , NE O'Brien1 , PB Mullan1 , RD Kennedy2 , DP Harkin2 and JE Quinn1 The BRCA1 tumour suppressor gene is mutated in a significant proportion of...
- 7From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): CM McKinnon1 and H Mellor1 Rho GTPases have multiple roles in cancer. We are working to characterise the novel Rho GTPase RhoBTB2/DBC2, which has been reported to be a tumour suppressor in breast cancer....
- 8From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): N Crawford1 , N Buckley1 , C Nic An tSaoir1 , D Tkocz1 , Z D'Costa1 , L Oram1 and P Mullan1 BRCA1 was identified in 1994 as one of the genes predisposing to early-onset breast and ovarian cancer. It is...
- 9From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): S Catchpole1 , B Spencer-Dene2 , D Hall1 , A Scibetta1 , J Burchell1 and J Taylor-Papadimitriou1 PLU-1/Jarid1B is a nuclear protein that is widely expressed in breast cancer, with higher levels being seen...
- 10From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): J Millour1 and EW Lam1 Previous data have shown that FOXM1 expression is elevated in breast cancer tissues and is strongly correlated with the expression pattern of ER[alpha] in breast cancer cells. The...
- 11From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): DM Sharp1,2,3 , MB Walker3 , A Chaturvedi3 , S Upadhyay3 , A Hamid3 , AA Walker3 , J Bateman3 , F Braid3 , K Ellwood3 , C Hebblewhite3 , T Hope3 , M Lines3 and LG Walker1,2,3 Objective To evaluate the...
- 12From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): SH Rigas1 , M Parry1 , MW Reed1 , N Camp2 and A Cox1 Rationale and hypothesis Mutations in high-penetrance genes such as BRCA1 and BRCA2 predispose to breast cancer, and recently a number of...
- 13From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): JR Morris1 , C Boutell2 , M Keppler1 , R Densham1 , D Weekes1 , A Alamshah1 , L Butler1 , Y Galanty3 , L Pangon1 , T Kiuchi1 , T Ng1 and E Solomon1 The breast and ovarian predisposition protein BRCA1 is a...
- 14From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): WF Symmans Abstract not available at time of publication. Correspondence: Author details: doi: 10.1186/bcr2489...
- 15From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): CM Woolston1 , L Zhang1 , H Evans1 , A Al-Attar2 , M Shehata2 , G Balls3 , SY Chan2 and SG Martin1 Redox systems are often deregulated in cancer. To investigate whether altered expression predicted...
- 16From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): AM Thompson1 , S Bray1 , AM Johnson2 , P Quinlan1 , DM Nikloff2 , DG Evans3 , R Clarke4 , HJ Lawrence2 , A Howell4 , A Latif3 , R Ferraldeschl3 , G Hillman2 , M Fontecha2 and WG Newman3 Tamoxifen efficacy...
- 17From: Breast Cancer Research. (Vol. 12, Issue 1) Peer-ReviewedTherapeutic choices for metastatic tumors are, in most cases, based upon the histological and molecular analysis of the corresponding primary tumor. Understanding whether and to what extent the genomic landscape of...
- 18From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): J Richardson1 , A Shaaban2 , M Kamal1 , I Ellis3 , V Speirs1 , A Green3 and SM Bell1 Previously we identified MCPH1, a DNA damage response protein involved in the regulation of BRCA1 and BRCA2 , as the...
- 19From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): A Gastaldello1 , P Gami1 , H Callaghan1 and M Campanella2 Dysfunctional mitochondria contribute to the onset of malignant transformation and growth. Molecules that regulate mitochondrial homeostasis are...
- 20From: Breast Cancer Research. (Vol. 12, Issue Suppl 1) Peer-ReviewedAuthor(s): HD McKeen1 , C Byrne1 , PV Jithesh1 , C Donley1 , A Yakkundi1 , L McCallum1 , HO McCarthy1 , DG Hirst1 and T Robson1 Approximately 40% of patients with oestrogen receptor (ER)-positive breast cancers do...