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- 1From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedCancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction...
- 2From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground and methods In order to characterize the expression pattern of SALL4, BMI-1 and ABCA3 genes in patients with myeloid leukemia and those who achieved complete remission (CR) after chemotherapy. Real-time...
- 3From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Cisplatin resistance is a serious problem in cancer treatment. To overcome it, alternative approaches including virotherapy are being pursued. One of the candidates for anticancer virotherapy is the...
- 4From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Paralemmin-1 is a phosphoprotein lipid-anchored to the cytoplasmic face of membranes where it functions in membrane dynamics, maintenance of cell shape, and process formation. Expression of paralemmin-1...
- 5From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Kaiso protein has been identified as a new member of the POZ-ZF subfamily of transcription factors that are involved in development and cancer. There is consistent evidence of the role of Kaiso and its...
- 6From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Although the peptidyl-prolyl isomerase, cyclophilin-A (peptidyl-prolyl isomerase, PPIA), has been studied for decades in the context of its intracellular functions, its extracellular roles as a major...
- 7From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground The outcome of chemotherapy in breast cancer is strongly influenced by multidrug resistance (MDR). Several surrogate markers of chemoresistance have been identified including - CD24 (cluster...
- 8From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedThis study progresses in the direction of identifying component(s) from the Mediterranean sponge, Spongia officinalis with anticonvulsant and analgesic activities. We investigated the efficacy of crude extract and its...
- 9From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Nasopharyngeal carcinoma (NPC) is a unique tumour of epithelial origin with a distinct geographical distribution, genetic predisposition and environmental as well as dietary influence as aetiological...
- 10From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Cellular FLICE-Inhibitory Protein (long form, c-FLIP.sub.L) is a critical negative regulator of death receptor-mediated apoptosis. Overexpression of c-FLIP.sub.L has been reported in many cancer cell lines...
- 11From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground While breast cancer (BC) is the major cause of death among women worldwide, there is no guarantee of better patient survival because many of these patients develop primarily metastases, despite efforts to...
- 12From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedCancer is a multifaceted molecular disorder that is modulated by a combination of genetic, metabolic and signal transduction aberrations, which severely impair the normal homeostasis of cell growth and death....
- 13From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Inhibition of kinases involved in the DNA damage response sensitizes cells to genotoxic agents by abrogating checkpoint-induced cell cycle arrest. CHK1 and WEE1 act in a pathway upstream of CDK1 to inhibit...
- 14From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and...
- 15From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground The Real-time PCR Array System is the ideal tool for analyzing the expression of a focused panel of genes. In this study, we will analyze the gene expression profile of pediatric acute myeloid leukemia...
- 16From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Given the high occurrence of prostate cancer worldwide and one of the major sources of the discovery of new lead molecules being medicinal plants, this research undertook to investigate the possible...
- 17From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Lycorine, a natural alkaloid extracted from Amaryllidaceae, has shown various pharmacological effects. Recent studies have focused on the potential antitumor activity of lycorine. In our previous study, we...
- 18From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Breast cancer is the most common cancer in the Arab world and it ranked first among Saudi females. Doxorubicin (DOX), an anthracycline antibiotic is one of the most effective anticancer agents used to...
- 19From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedBackground Glioblastoma is the most aggressive form of brain tumors showing resistance to treatment with various chemotherapeutic agents. The most effective way to eradicate glioblastoma requires the concurrent...
- 20From: Cancer Cell International. (Vol. 12, Issue 1) Peer-ReviewedChronic myeloid leukemia (CML) is a stem cell disease in which BCR/ABL plays an important role as an oncoprotein and a molecular and immunogenic target. Despite the success of targeted therapy using tyrosine kinase...