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- 1From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground Expression of the constitutively activated mutant EGFR variant III (EGFRvIII), the most common mutation in glioblastoma multiforme (GBMs), has been clinically correlated with tumor proliferation, invasion,...
- 2From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground Neuroblastoma is responsible for 15% of all childhood cancer deaths. Despite advances in treatment and disease management, the overall 5-year survival rates remain poor in high-risk disease (25-40%)....
- 3From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground Although mammary cancer (MC) is the most common malignant neoplasia in women, the mortality for this cancer has decreased principally because of early detection and the use of neoadjuvant chemotherapy. Of...
- 4From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground NUP98 gene rearrangements have been reported in acute myeloid leukemia, giving rise to fusion proteins that seem to function as aberrant transcription factors, and are thought to be associated with poor...
- 5From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground It has been shown in many solid tumors that the overexpression of the pro-survival Bcl-2 family members Bcl-2/Bcl-xL and Mcl-1 confers resistance to a variety of chemotherapeutic agents. We designed the...
- 6From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground Efficacious application of HER2-targetting agents requires the identification of novel predictive biomarkers. Lapatinib, afatinib and neratinib are tyrosine kinase inhibitors (TKIs) of HER2 and EGFR growth...
- 7From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground The Vav family of Rho/Rac guanosine nucleotide exchange factors comprises three members in mammalian cells. Vav3 enhances androgen receptor (AR) activity during progression to androgen independence in...
- 8From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedObjectives Palytoxin (PTX), a marine toxin isolated from the Cnidaria (zooanthid) Palythoa caribaeorum is one of the most potent non-protein substances known. It is a very complex molecule that presents both...
- 9From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedContributing reviewers As 2013 commences I would like to take a moment to reflect and recognize the peer reviewers that made the previous year possible. Listed below are those people who reviewed for Molecular Cancer...
- 10From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground Overexpression of CD98hc (SLC3A2) occurs in a variety of cancers and is suspected to contribute to tumor growth. CD98, a heterodimeric transmembrane protein, physically associates with certain integrin...
- 11From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground The cellular and molecular mechanisms that mediate interactions between tumour cells and the surrounding bone stroma are to date largely undetermined in prostate cancer (PCa) progression. The purpose of...
- 12From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground The lung squamous cell carcinoma survival rate is very poor despite multimodal treatment. It is urgent to discover novel candidate biomarkers for prognostic assessment and therapeutic targets to lung...
- 13From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground Macrophages, the key component of the tumor microenvironment, are differentiated mononuclear phagocyte lineage cells that are characterized by specific phenotypic characteristics that have been implicated...
- 14From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground CRIP1 (cysteine-rich intestinal protein 1) has been found in several tumor types, its prognostic impact and its role in cellular processes, particularly in breast cancer, are still unclear. Methods...
- 15From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedPancreatic ductal adenocarcinoma (PDAC) has one of the poorest prognoses among all cancers. Over the past several decades, investigators have made great advances in the research of PDAC pathogenesis. Importantly,...
- 16From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedReversible protein ubiquitination is emerging as a key process for maintaining cell homeostasis, and the enzymes that participate in this process, in particular E3 ubiquitin ligases and deubiquitinases (DUBs), are...
- 17From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground The exposure of skin keratinocytes to Ultraviolet (UV) irradiation leads to Akt phosphorylation at Ser-473, which is important for the carcinogenic effects of excessive sun exposure. The present study...
- 18From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground Tumor cells produce various cytokines and chemokines that attract leukocytes. Leukocytes can amplify parenchymal innate immune responses, and have been shown to contribute to tumor promotion. Neutrophils...
- 19From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground Radiation induced transcriptional targeting is a gene therapy approach that takes advantage of the targeting abilities of radiotherapy by using radio inducible promoters to spatially and temporally limit...
- 20From: Molecular Cancer. (Vol. 12, Issue 1) Peer-ReviewedExosomes can be viewed as complex "messages" packaged to survive trips to other cells in the local microenvironment and, through body fluids, to distant sites. A large body of evidence indicates a pro-metastatic role...