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- 1From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Economic implications of chemotherapy-induced febrile neutropenia (FN) in European and Australian clinical practice are largely unknown. Methods Data were obtained from a European (97%) and Australian...
- 2From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with .sup.18F-fluorodeoxyglucose-positron-emission-tomography (PET). Since interim-PET is an important prognostic tool in...
- 3From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Knowledge about signaling pathways in malignant cells may provide prognostic and diagnostic information in addition to identify potential molecular targets for therapy. B-cell receptor (BCR) and co-receptor...
- 4From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground It has previously been shown that indirubin derivative E804 (IDR-E804) blocks signal transducer and activator of transcription-3 signaling in human breast and prostate cancer cells and inhibits Src kinase...
- 5From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Despite recent advances in the treatment of hepatocellular carcinoma (HCC), the chemotherapy efficacy against HCC is still unsatisfactory. The mammalian target of rapamycin (mTOR) has been emerged as an...
- 6From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground MicroRNAs (miRNAs) and their role during tumor development have been studied in great detail during the last decade, albeit their expression pattern and regulation during normal development are however not...
- 7From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground One-third of breast cancers display amplifications of the ERBB2 gene encoding the HER2 kinase receptor. Trastuzumab, a humanized antibody directed against an epitope on subdomain IV of the extracellular...
- 8From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Hodgkin lymphoma (HL) is one of the most frequent lymphoma in the western world. Despite a good overall prognosis, some patients suffer relapsing tumors which are difficult to cure. Over a long period...
- 9From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Abnormal NF-κB2 activation has been implicated in the pathogenesis of multiple myeloma, a cancer of plasma cells. However, a causal role for aberrant NF-κB2 signaling in the development of plasma cell...
- 10From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Chemotherapy is the mainstay of non-Hodgkin lymphoma (NHL) treatment. Based on expert opinion, the use of radiotherapy (RT) is currently preferred in some institutions as consolidative treatment for patients...
- 11From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Historically, the median overall survival for follicular lymphoma (FL) has been considered to be 9-10 years, and no treatment had ever prolonged this time period. Studies conducted more than 20 years ago...
- 12From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Cutaneous squamous cell carcinoma (SCC) is associated with underlying immunosuppression, so it may be a prognostic marker in patients with subsequent cancer. We therefore conducted a nationwide...
- 13From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground The transcription factor SOX11 is of diagnostic and prognostic importance in mantle cell lymphoma (MCL) and epithelial ovarian cancer (EOC), respectively. Thus, there is an unmet clinical and experimental...
- 14From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Anaplastic lymphoma kinase-positive, anaplastic large cell lymphoma (ALK+ ALCL) is a T cell lymphoma defined by the presence of chromosomal translocations involving the ALK tyrosine kinase gene. These...
- 15From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Triple-negative breast cancer (TNBC) exhibit characteristics quite distinct from other kinds of breast cancer, presenting as an aggressive disease--recurring and metastasizing more often than other kinds...
- 16From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground P53 mutations are an adverse prognostic factor in esophageal cancer. P53 and KRas mutations are involved in chemo-radioresistance. Circulating anti-p53 or anti-KRas antibodies are associated with gene...
- 17From: BMC Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground A life threatening illness such as breast cancer can lead to a secondary diagnosis of PTSD (post traumatic stress disorder) with intrusive thoughts and avoidance as major symptoms. In a former study by the...
- 18From: BMC Cancer. (Vol. 12, Issue 1) Peer-ReviewedBackground To investigate the prognostic significance of disseminated tumor cells (DTCs) in bone marrow (BM) from non-metastatic breast cancer patients before and after surgery. Methods Patients with...
- 19From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground Most skin cancers are preventable by encouraging consistent use of sun protective behaviour. In Australia, adolescents have high levels of knowledge and awareness of the risks of skin cancer but exhibit...
- 20From: BMC Cancer. (Vol. 12) Peer-ReviewedBackground The current standard treatment, at least in Europe, for patients with primarily resectable tumors, consists of surgery followed by adjuvant chemotherapy. But even in this prognostic favourable group, long...