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- 1From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedVaccination has played a significant role in controlling and eliminating life-threatening infectious diseases throughout the world, and yet currently licensed vaccines represent only the tip of the iceberg in terms of...
- 2From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedVSMCs respond to changes in the local environment by adjusting their phenotype from contractile to synthetic, a phenomenon known as phenotypic modulation or switching. Failure of VSMCs to acquire and maintain the...
- 3From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedThe cellular and molecular microenvironment of epithelial stem and progenitor cells is poorly characterized despite well-documented roles in homeostatic tissue renewal, wound healing, and cancer progression. Here, we...
- 4From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedDavid H. Adler, Joy D. Cogan, John A. Phillips III, Nathalie Schnetz-Boutaud, Ginger L. Milne, Tina Iverson, Jeffrey A. Stein, David A. Brenner, Jason D. Morrow, Olivier Boutaud, and John A. Oates Original citation:...
- 5From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedGenetic instability, which leads to an accumulation of various genetic abnormalities, has been considered an essential component of the human neoplasic transformation process. However, the molecular basis of genomic...
- 6From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedVSMCs exhibit phenotypic plasticity, switching from a contractile phenotype to a synthetic phenotype in response to environmental cues, many of which (such as hypertension and arteriosclerosis) are associated with human...
- 7From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedThe increasing availability of complete genome sequences of RNA viruses has the potential to shed new light on fundamental aspects of their biology. Here, I use case studies of 3 RNA viruses to explore the impact of...
- 8From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedWhen has an author been scooped? It sounds like a simple question, but in fact, as a recent editorial meeting unfolded, this issue became far more complex than I had thought. Members of the JCI Editorial Board...
- 9From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedAldosterone regulates volume homeostasis and blood pressure by enhancing sodium reabsorption in the kidney's distal nephron (DN). On the apical surface of these renal epithelia, aldosterone increases expression and...
- 10From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedSirtuin 3 (SIRT3) is a member of the sirtuin family of proteins that promote longevity in many organisms. Increased expression of SIRT3 has been linked to an extended life span in humans. Here, we have shown that Sirt3...
- 11From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedFearing that the fall flu season in combination with the return of children to school could trigger a spike in swine flu cases, the National Institute of Allergy and Infectious Diseases has begun clinical trials of...
- 12From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedHomeobox (Hox) genes encode transcription factors that act as critical regulators of growth and differentiation during embryogenesis. While many studies have identified increased expression of Hox genes in tumors, much...
- 13From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedSix1 is a developmentally regulated homeoprotein with limited expression in most normal adult tissues and frequent misexpression in a variety of malignancies. Here we demonstrate, using a bitransgenic mouse model, that...
- 14From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedBasic research into human mature myelomonocytic cell function, myeloid lineage diversification and leukemic transformation, and assessment of myelotoxicity in preclinical drug development requires a constant supply of...
- 15From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedBone marrow transplantation (BMT) represents a cure for nonmalignant hematological disorders. However, compared with the stringent conditioning regimens used when performing BMT to treat hematological malignancies, the...
- 16From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedCaveolae are invaginations of the plasma membrane involved in many cellular processes, including clathrin-independent endocytosis, cholesterol transport, and signal transduction. They are characterized by the presence...
- 17From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedThe observation that only a fraction of individuals infected by infectious agents develop clinical disease raises fundamental questions about the actual pathogenesis of infectious diseases. Epidemiological and...
- 18From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedDCs are specialized APCs that orchestrate innate and adaptive immune responses. The intestinal mucosa contains numerous DCs, which induce either protective immunity to infectious agents or tolerance to innocuous...
- 19From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedParacrine signaling from lung epithelium to the surrounding mesenchyme is important for lung SMC development and function and is a contributing factor in an array of pulmonary diseases such as bronchopulmonary...
- 20From: Journal of Clinical Investigation. (Vol. 119, Issue 9) Peer-ReviewedPharmacologic blockade of EGFR or the closely related receptor ERBB2 has modest efficacy against colorectal cancers in the clinic. Although the upregulation of ERBB3, a pseudo-kinase member of the EGFR/ERBB family, is...