Showing Results for
- Academic Journals (44)
Search Results
- 44
Academic Journals
- 44
- Search Terms:
- 1From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedNeuropathy and myopathy can cause weakness during critical illness. To determine whether reduced excitability of peripheral nerves, rather than degeneration, is the mechanism underlying acute neuropathy in critically ill...
- 2From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedIdiopathic pulmonary fibrosis (IPF) can lead to the development of secondary pulmonary hypertension (PH) and ultimately death. Despite this known association, the precise mechanism of disease remains unknown. Using a rat...
- 3From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedThe uptake of lipoproteins by macrophages is a critical step in the development of atherosclerotic lesions. Cultured monocyte-derived macrophages take up large amounts of native LDL by receptor-independent fluid-phase...
- 4From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedImatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance increases in advancing...
- 5From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedEdited by Ellen S. More, Elizabeth Fee, and Manon Parry Johns Hopkins University Press. Baltimore, Maryland, USA. 2008. 376 pp. $25.00. ISBN: 978-0-8018-90383 (paperback). When Elizabeth Blackwell, daughter of an Ohio...
- 6From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-Reviewed
Focal and segmental glomerulosclerosis induced in mice lacking decay-accelerating factor in T cells.
Heritable and acquired diseases of podocytes can result in focal and segmental glomerulosclerosis (FSGS). We modeled FSGS by passively transferring mouse podocyte--specific sheep Abs into BALB/c mice. BALB/c mice... - 7From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedLeukocyte and platelet accumulation at sites of cerebral ischemia exacerbate cerebral damage. The ectoenzyme CD39 on the plasmalemma of endothelial cells metabolizes ADP to suppress platelet accumulation in the ischemic...
- 8From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedThe progression of kidney disease to renal failure correlates with infiltration of mononuclear immune cells into the tubulointerstitium. These infiltrates contain macrophages, DCs, and T cells, but the role of each cell...
- 9From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedStudies in animals have documented that, compared with glucose, dietary fructose induces dyslipidemia and insulin resistance. To assess the relative effects of these dietary sugars during sustained consumption in humans,...
- 10From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedThe incidence of tuberculosis is increased during treatment of autoimmune diseases with anti-TNF antibodies. This is a significant clinical complication, but also provides a unique model to study immune mechanisms in...
- 11From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedSLE, a chronic, multisystem autoimmune disorder with a broad range of symptoms, involves defective B cell selection and elimination of self-reactive B cells. B lymphocyte stimulator (BLyS), a soluble ligand of the TNF...
- 12From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedAnti-TNF immunotherapy has revolutionized the treatment of some inflammatory diseases, such as RA. However, a major concern is that patients receiving this therapy have an increased risk of fungal and bacterial...
- 13From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedHepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active lipogenesis. Hepatic lipogenesis depends on the insulin-induced activation of the transcription factor SREBP-1c. Despite...
- 14From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedThe mammalian intestines are home to a large number of species of bacteria, the identity of which affects both tissue homeostasis and the occurrence of immune-mediated pathology. Despite the importance of these commensal...
- 15From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-Reviewed[Ca.sup.2+]/calmodulin--dependent kinase II (CaMKII) has been implicated in cardiac hypertrophy and heart failure. We generated mice in which the predominant cardiac isoform, CaMKIIδ, was genetically deleted (KO mice),...
- 16From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedCranial radiation therapy to treat brain cancer can damage hippocampal neurons, causing long-term neurological deficiencies, particularly in children. Previous studies have indicated that lithium, which is used to treat...
- 17From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedHIV-1-associated nephropathy (HIVAN) is a common complication of HIV-1 infection, and its skewed incidence in certain ethnic groups suggests that there is a genetic basis to HIVAN susceptibility. In their study reported...
- 18From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedNK cells use a variety of receptors to detect abnormal cells, including tumors and their metastases. However, in the case of melanoma, it remains to be determined what specific molecular interactions are involved and...
- 19From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedMost scientists learn how to review papers by being thrown into the deep end of the pool: here's a paper, write a review. Perhaps this is not the best way to keep an enterprise afloat. But what should be included in a...
- 20From: Journal of Clinical Investigation. (Vol. 119, Issue 5) Peer-ReviewedRuth Richardson Oxford University Press. New York, New York, USA. 2008. 322 pp. $29.95. ISBN: 978-0-19-955299-3 (hardcover). The making of Mr. Gray's anatomy chronicles the fascinating story of one of the most widely...