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- 1From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedTo the editor The X-ray repair cross-complementation group 1 (XRCC1) protein plays an important role in base excision repair [1]. Xrccl-deficient mouse or hamster cells are hypersensitive to DNA damaging agents and...
- 2From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedThe down-regulation of genes involved in normal cell division can cause aberrant mitoses and increased cell death. Surviving cells exhibit aneuploidy and/or polyploidy. Since mitotic disruption has been linked with...
- 3From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedA serious complication associated with breast cancer treatment is the increased risk for development of therapy-related myeloid neoplasms (t-MN). To determine whether dose-intensive adjuvant regimens for breast cancer...
- 4From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedRecent findings indicate a greater risk of postmenopausal breast cancer with estrogen-progestagen therapy than estrogen monotherapy, and more so for current than past use. Few studies have examined individual genetic...
- 5From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedGerm line mutations in the tumor suppressor gene, p53, are known to cause Li-Fraumeni syndrome (LFS) or Li-Fraumeni-like syndrome (LFL). We sought to identify p53 germ line mutations in potential hereditary breast...
- 6From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedBreast cancer is known to cause metastatic lesions in the bone, which can lead to skeletal-related events. Currently, radiation therapy and surgery are the treatment of choice, but the success rate varies and additional...
- 7From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedIn carcinomas such as those of breast, pancreas, stomach, and colon, cancer cells support the expansion of molecular and cellular stroma in a phenomenon termed desmoplasia, which is characterized by a strong fibrotic...
- 8From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedThe CAN-NCIC-MA22 phase I/II clinical trial evaluated women with locally advanced or inflammatory breast cancer treated with epirubicin and docetaxel at 2 or 3 weekly intervals in sequential cohorts. The relationship...
- 9From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedBiallelic inactivation of the ATM gene causes ataxia-telangiectasia (A-T), a complex neurological disease associated with a high risk of leukaemias and lymphomas. Mothers of A-T children, obligate ATM heterozygote...
- 10From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedOur objective was to examine the association between self-reported breast cancer risk factors and reported physician recommendations for mammography among women younger than 40. This study uses the 2005 National Health...
- 11From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedSeveral adipocytokines, such as leptin or adiponectin, are associated with obesity and the risk for breast cancer. Adiopcyte fatty acid binding-protein (A-FABP) is another protein found in adipose tissue; therefore, we...
- 12From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedAn RNAi-based functional screening of mitotic kinases in Drosophila recently identified a number of members of the kinome that are required for normal cell division. Depletion of these kinases resulted in a number of...
- 13From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedRe-excision rates after breast conserving surgery (BCS) of invasive lobular carcinoma (ILC) are high. Preoperative breast MRI has the potential to reduce re-excision rates, but may lead to an increased rate of...
- 14From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedTransferrin receptor (CD71) is involved in the cellular uptake of iron and is expressed on cells with high proliferation. It may be implicated in promoting the growth of endocrine resistant phenotypes within...
- 15From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedInhibition or downregulation of Bcl-2 represents a new therapeutic approach to by-pass chemoresistance in cancer cells. Therefore, we explored the potential of this approach in breast cancer cells. Cisplatin and...
- 16From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedIn order to assess the characteristics of malignant breast lesions those were not detected during screening by MR imaging. In the Dutch MRI screening study (MRISC), a non-randomized prospective multicenter study, women...
- 17From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedHeterozygous somatic mutations of the transcription factor, GATA-3, have recently been reported in approximately 5% breast of tumors unselected for family history. We sequenced the GATA-3 gene in 55 breast tumors from...
- 18From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedSeveral tools for predicting the likelihood of non-sentinel lymph node (non-SLN) involvement in SLN-positive breast cancer patients have been created so far. The aim of our study was to create and validate different...
- 19From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedMitochondrial genome alterations have been suggested to play an important role in carcinogenesis. The D-loop region of mitochondrial DNA (mtDNA) contains essential transcription and replication elements, and mutations...
- 20From: Breast Cancer Research and Treatment. (Vol. 119, Issue 2) Peer-ReviewedGenetic testing for BRCAI and BRCA2 mutations in family members of individuals with known deleterious mutations can distinguish between patients at high risk of disease and those who are not. Some studies have suggested...