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- 1From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedMany hepatic genes encoding proteins that control metabolic pathways are differentially expressed in males and females. Much of this hepatic sexual dimorphism is caused by differences in pituitary growth hormone...
- 2From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedIn the heated debate about health care reform, there has been little serious discussion about how to fix the extraordinarily expensive and inefficient delivery system that makes meaningful expansion of coverage...
- 3From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedSecondary hyperparathyroidism is a major complication of chronic kidney disease (CKD). In experimental models of secondary hyperparathyroidism induced by hypocalcemia or CKD, parathyroid hormone (PTH) mRNA levels...
- 4From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedThe role of B cells and autoimmunity as contributing factors to poor neurological outcomes following spinal cord injury (SCI) is poorly understood. The study by Ankeny et al., in this issue of the JCI, identifies a new...
- 5From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedAmerican medicine has much to be proud of. Since World War II, the National Institutes of Health has sparked a revolution in academic biomedical research. There are world-leading academic hospitals delivering the...
- 6From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedVarious acute and chronic inflammatory stimuli increase the number and activity of pulmonary mucus-producing goblet cells, and goblet cell hyperplasia and excess mucus production are central to the pathogenesis of...
- 7From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedWhile the thymus is known to be essential for the initial production of T cells during early life, its contribution to immune development remains a matter of debate. In fact, during cardiac surgery in newborns, the...
- 8From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedEconomic and political experts appear to agree that the US health care system is a horrible mess, and there is no consensus as to how to fix it. The differential diagnosis is that our health care system: (a) is dying...
- 9From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedViruses that infect T cells, including those of the lentivirus genus, such as HIV-1, modulate the responsiveness of infected T cells to stimulation by interacting APCs in a manner that renders the T cells more...
- 10From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedTaking control of the insatiable American appetite David A. Kessler Rodale Books. Emmaus, Pennsylvania, USA. 2009. 320 pp. $25.95. ISBN: 978-1-60529-785-9 (hardcover). In The end of overeating: taking...
- 11From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedAs a physician-scientist elected to represent the American Society for Clinical Investigation, I hope to provide a voice for at least some of the physician-scientists who tirelessly devote their energies to translating...
- 12From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedBone undergoes a continuous cycle of renewal, and osteoclasts--the cells responsible for bone resorption--play a pivotal role in bone homeostasis. This resorption is largely mediated by inflammatory cytokines such as...
- 13From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedGoblet cells are mucus-producing epithelial cells normally found in only small numbers in the respiratory tract lining. However, many acute and chronic inflammatory stimuli increase the number and activity of pulmonary...
- 14From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedCyclin I is an atypical cyclin because it is most abundant in postmitotic cells. We previously showed that cyclin I does not regulate proliferation, but rather controls survival of podocytes, terminally differentiated...
- 15From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedX-linked lymphoproliferative disease (XLP) is a rare inherited immunodeficiency most commonly caused by deficiency in SLAM-associated protein (SAP). Following primary infection with EBV, boys with XLP often develop an...
- 16From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedWe are in the midst of a vitally important discussion on health care. This debate has provided insights into who we are as Americans and what we value. We clearly value our health and our health care. We believe that...
- 17From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedSeborrheic keratoses (SKs) are common, benign epithelial tumors of the skin that do not, or very rarely, progress into malignancy, for reasons that are not understood. We investigated this by gene expression profiling...
- 18From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedX-linked lymphoproliferative disease (XLP) is a rare congenital immunodeficiency that leads to an extreme, usually fatal increase in the number of lymphocytes upon infection with EBV. It is most commonly defined...
- 19From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedBy 2018, health care expenditures are expected to consume more than 20% of US gross domestic product (1). Over the last decade, there has been a marked increase in health care spending without corresponding improvements...
- 20From: Journal of Clinical Investigation. (Vol. 119, Issue 10) Peer-ReviewedTo date, inheritance of a mutant BRCA1 or BRCA2 gene is the best-established indicator of an increased risk of developing breast cancer. Sequence analysis of these genes is being used to identify BRCA1/2 mutation...