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- 1From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedInflammation plays a critical role in the development of cardiovascular diseases. Infiltration of leukocytes to sites of injury requires their exit from the blood and migration across basement membrane; this process has...
- 2From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedThe AKT/mamnialian target of rapamycin (AKT/mTOR) and ERK MAPK signaling pathways have been shown to cooperate in prostate cancer progression and the transition to androgen-independent disease. We have now tested the...
- 3From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedWhen blood is exposed to negatively charged surface materials such as glass, an enzymatic cascade known as the contact system becomes activated. This cascade is initiated by autoactivation of Factor XII and leads to...
- 4From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedPKC isoforms [tau], [alpha], and [beta] play fundamental roles in the activation of T cells and other immune cell functions. Here we show that the PKC inhibitor AEB071 both abolishes the production of several cytokines...
- 5From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedEndocannabinoids have been implicated in the development of many effects of a high-fat diet, including obesity, fatty liver (hepatic steatosis), insulin resistance, leptin resistance, and dyslipidemia. However, whether...
- 6From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedPhysiologic hemostasis upon injury involves many plasma proteins in a well-regulated cascade of proteolytic reactions to form a clot. Deficiency of blood coagulation Factors VIII, IX, or XI is associated with...
- 7From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedThe expression of several enzymes that metabolize xenobiotics--entirely synthetic chemicals and drugs--is regulated by the closely related orphan nuclear hormone receptors pregnane X receptor (PXR) and constitutive...
- 8From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedTom Daschle with Scott S. Greenberger and Jeanne M. Lambrew Thomas Dunne Books. New York, New York, USA. 2008. 240 pp. $23.95. ISBN: 978-0-312-38301-5 (hardcover). In Critical, former U.S. Senate Majority Leader Tom...
- 9From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedMultiple receptor tyrosine kinases (RTKs), including PDGFR, have been validated as therapeutic targets in glioblastoma multiforme (GBM), yet inhibitors of RTKs have had limited clinical success. As various antiapoptotic...
- 10From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedMarking a path to transplant tolerance Vicki Seyfert-Margolis and Laurence A. Turka Original citation: J. Clin. Invest. 118:2684-2686 (2008). doi:10.1172/JCI36552. Citation for this erratum: J. Clin. Invest....
- 11From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedThe National Institute of Allergy and Infectious Diseases (NIAID) decided recently to cancel plans for a large clinical trial of a candidate vaccine against HIV. The canceled clinical trial, known as PAVE 100, was...
- 12From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedParkinson disease (PD) is characterized by dopaminergic neurodegeneration and intracellular inclusions of [alpha]-synuclein amyloid fibers, which are stable and difficult to dissolve. Whether inclusions are...
- 13From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedIatrogenic tumor cell implantation within surgical wounds can compromise curative cancer surgery. Adhesion of cancer cells, in particular colon cancer cells, is stimulated by exposure to increased extracellular pressure...
- 14From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedSome cases of pre--B cell acute lymphoblastic leukemia (pre--B-ALL) are caused by the Philadelphia (Ph) chromosome--encoded BCR-ABL oncogene, and these tend to have a poor prognosis. Inhibitors of the PI3K/AKT pathway...
- 15From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedArterial blood flow enhances glycoprotein Ib[alpha] (GPIb[alpha]) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand disease (vWD)...
- 16From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedMammalian target of rapamycin (mTOR) is a component of a signaling pathway (PTEN/PI3K/AKT) that is frequently dysregulated in cancer. However, its precise relationship to the MAPK cascade (Ras/Raf/MEK/ERK), another...
- 17From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedPreviously, several individuals with X-linked SCID (SCID-X1) were treated by gene therapy to restore the missing IL-2 receptor [gamma] (IL2RG) gene to [CD34.sup.+] BM precursor cells using gammaretroviral vectors. While...
- 18From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedGain-of-function NOTCH1 mutations are found in 50%-70% of human T cell acute lymphoblastic leukemia/lymphoma (T-ALL) cases. Gain-of-function NOTCH1 alleles that initiate strong downstream signals induce leukemia in...
- 19From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedAtherosclerosis remains a major cause of death in the developed world despite the success of therapies that lower cholesterol and BP. The intermediate-conductance calcium-activated potassium channel KCa3.1 is expressed...
- 20From: Journal of Clinical Investigation. (Vol. 118, Issue 9) Peer-ReviewedThe interaction of circulating platelets with the vessel wall involves a process of cell catch and release, regulating cell rolling, skipping, or firm adhesion and leading to thrombus formation in flowing blood. In this...