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- 1From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedAngiogenesis and/or neovascularization is important for the growth, progression, and metastasis of malignant tumors, and recent evidence has indicated that mobilization of endothelial progenitor cells (EPCs) from the...
- 2From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedHelminths are parasitic worms. They are the most common infectious agents of humans in developing countries and produce a global burden of disease that exceeds better-known conditions, including malaria and tuberculosis....
- 3From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedIn this perspective, I trace my experiences with the ASCI, beginning in 1952, when as a medical student I attended my first meeting, until 1975, when I completed my term as president of the Society. I focus attention on...
- 4From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedThe essential contribution of the antidepressant-sensitive serotonin (5-HT) transporter SERT (which is encoded by the SLC6A4 gene) to platelet 5-HT stores suggests an important role of this transporter in platelet...
- 5From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedAdministration of the CD28 superagonistic antibody JJ316 is an efficient means to treat autoimmune diseases in rats, but the humanized antibody TGN1412 caused devastating side effects in healthy volunteers during a...
- 6From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedIn March 2006, a phase I study of the superagonistic anti-CD28 antibody TGN1412 caused a massive cytokine storm and multiorgan failure in six healthy human volunteers. Such a profound impact on the immune system was not...
- 7From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedCatherine Brady The MIT Press. Cambridge, Massachusetts, USA. 2007. 424 pp. $29.95. ISBN: 978-0-262-02622-2 (hardcover). In the early 1980s, Elizabeth Blackburn made a discovery that changed cell biology. Working...
- 8From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedThe American Society for Clinical Investigation has supported the career development of physician-scientists for the past 100 years. As the ASCI looks to its next 100 years, it must be a leading force, not only for...
- 9From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedIn this article, I reflect on the unique value for the societies of academic internal medicine of their annual spring meetings that were held in Atlantic City for two generations prior to 1977 and consider whether...
- 10From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedPneumonia is an illness, usually caused by infection, in which the lungs become inflamed and congested, reducing oxygen exchange and leading to cough and breathlessness. It affects individuals of all ages but occurs most...
- 11From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-Reviewed13-cis retinoic acid (13-cis RA; also known as isotretinoin) is the most potent agent available for the treatment of acne. Use of the drug is limited due to teratogenic side effects, however, and there is no available...
- 12From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedPriapism, abnormally prolonged penile erection in the absence of sexual excitation, is associated with ischemia-mediated erectile tissue damage and subsequent erectile dysfunction. It is common among males with sickle...
- 13From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedWhere once the annual meeting of the American Federation for Clinical Research, the American Society for Clinical Investigation, and the Association of American Physicians could unite the whole of clinical investigation,...
- 14From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedBardet-Biedl syndrome (BBS) is a heterogeneous genetic disorder characterized by many features, including obesity and an increased risk of hypertension and cardiovascular disease. To date, mutations in 12 BBS genes have...
- 15From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedMobilization of endothelial progenitor cells (EPCs) from the bone marrow and their subsequent participation in neovessel formation are implicated in tumor growth and neovascularization. As the neurotransmitter dopamine...
- 16From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedTuberculosis (TB) is a major threat to global health, recently exacerbated by the emergence of highly drug-resistant forms of the disease-causing pathogen and synergy with HIV/AIDS. In 2006, the Stop TB Partnership...
- 17From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedBardet-Biedl syndrome (BBS) is a heterogeneous genetic disorder characterized by many features, including obesity and cardiovascular disease. We previously developed knockout mouse models of 3 BBS genes: BBS2, BBS4, and...
- 18From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedThe ASCI is notable for two unique functions--the annual meeting and The Journal of Clinical Investigation. Both have inspired us over the 37 years of our collaborative adventures in research. In this retrospective, we...
- 19From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedThe growth of normal cells is arrested when they come in contact with each other, a process known as contact inhibition. Contact inhibition is lost during tumorigenesis, resulting in uncontrolled cell growth. Here, we...
- 20From: Journal of Clinical Investigation. (Vol. 118, Issue 4) Peer-ReviewedHyperkalemic periodic paralysis (HyperKPP) produces myotonia and attacks of muscle weakness triggered by rest after exercise or by [K.sup.+] ingestion. We introduced a missense substitution corresponding to a human...