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- 1From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedMyocardin (Myocd) is a potent transcriptional coactivator that has been implicated in cardiovascular development and adaptation of the cardiovascular system to hemodynamic stress. To determine the function of myocardin...
- 2From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedLocal anesthetics (LAs) block the generation and propagation of action potentials by interacting with specific sites of voltage-gated [Na.sup.+] channels. LAs can also excite sensory neurons and be neurotoxic through...
- 3From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedAn important, unfilled clinical need is the development of new approaches to improve fracture healing and to treat osteoporosis by increasing bone mass. Recombinant forms of bone morphogenetic protein 2 (BMP2) and BMP7...
- 4From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedT cell Ig mucin (Tim) molecules modulate [CD4.sup.+] T cell responses. In keeping with the view that Tim-1 generates a stimulatory signal for [CD4.sup.+] T cell activation, we hypothesized that an agonist Tim-1-specific...
- 5From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedChronic inflammatory disorders are often associated with an increased cancer risk. A particularly striking example of the chronic inflammation--cancer link is seen in inflammatory bowel disease, in which chronic colitis...
- 6From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedMany patients with anemia fail to respond to treatment with erythropoietin (Epo), a commonly used hormone that stimulates erythroid progenitor production and maturation by human BM or by murine spleen. The protein...
- 7From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedAberrant glycosylation of IgA1 plays an essential role in the pathogenesis of IgA nephropathy. This abnormality is manifested by a deficiency of galactose in the hinge-region O-linked glycans of IgA1. Biosynthesis of...
- 8From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedEosinophilic inflammation is a cornerstone of chronic asthma that often culminates in subepithelial fibrosis with variable airway obstruction. Pulmonary eosinophils (Eos) are a predominant source of TGF-β1, which drives...
- 9From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedType 2 diabetes (T2D) frequently occurs in the context of abnormalities of plasma lipoproteins. However, a role for elevated levels of plasma cholesterol in the pathogenesis of this disease is not well established....
- 10From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedMitochondrial dysfunction in skeletal muscle has been implicated in the development of type 2 diabetes. However, whether these changes are a cause or a consequence of insulin resistance is not clear. We investigated the...
- 11From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedThe brain of individuals who suffer from epilepsy is characterized by astrogliosis. Little is known about the mechanisms that link astrogliosis to neuronal dysfunction, but it is hoped that identifying these mechanisms...
- 12From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedTendons and ligaments are unique forms of connective tissue that are considered an integral part of the musculoskeletal system. The ultimate function of tendon is to connect muscles to bones and to conduct the forces...
- 13From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedDespite progress in cardiovascular research, a cure for peripheral vascular disease has not been found. We compared the vascularization and tissue regeneration potential of murine and human undifferentiated multipotent...
- 14From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedInflammation is a rapid yet coordinated response that can lead to the destruction of microbes and host tissue. Triggers capable of inducing an inflammatory response include tissue damage and infection by pathogenic and...
- 15From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedEdmund H. Sonnenblick, the Safra Distinguished University Professor of Medicine and chief emeritus of the Division of Cardiology at the Albert Einstein College of Medicine, died on September 22, 2007, of esophageal...
- 16From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedAPOE genotype is a major genetic risk factor for late-onset Alzheimer disease (AD). ABCA1, a member of the ATP-binding cassette family of active transporters, lipidates apoE in the CNS. Abca1-/- mice have decreased lipid...
- 17From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedPrimary biliary cirrhosis (PBC) is a cholestatic disease associated with autoimmune phenomena and alterations in both biliary bicarbonate excretion and expression of the bicarbonate carrier AE2. The bile acid...
- 18From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedThe mechanisms underlying the susceptibility of individuals with caspase recruitment domain 15 (CARD15) mutations and corresponding abnormalities of nucleotide-binding oligomerization domain 2 (NOD2) protein to Crohn...
- 19From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedElizabeth Siegel Watkins Johns Hopkins University Press. Baltimore, Maryland, USA. 2007. 368 pp. $45.00. ISBN: 978-0-8018-8602-7 (hardcover). Reviewed by Wulf H. Utian The North American Menopause Society,...
- 20From: Journal of Clinical Investigation. (Vol. 118, Issue 2) Peer-ReviewedMutation in superoxide dismutase-1 (SOD1) causes the inherited degenerative neurological disease familial amyotrophic lateral sclerosis (ALS), a non--cell-autonomous disease: mutant SOD1 synthesis in motor neurons and...