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- 1From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedIncreased cap-dependent mRNA translation rates are frequently observed in human cancers. Mechanistically, many human tumors often overexpress the cap binding protein eukaryotic translation initiation factor 4E (eIF4E),...
- 2From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedNonstandard abbreviations used: BCR, B cell receptor; DLBCL, diffuse large B cell lymphoma; ITAM, immunoreceptor tyrosine-based activation motif; 4OHT, 4-hydroxytamoxifen; Pax5ERTAM, fusion of Pax5 and tamoxifen...
- 3From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedNonstandard abbreviations used: ACO, acyl-CoA oxidase; AgRP, agouti-related protein; CART, cocaine-amphetamine- related transcript; CPT-1, carnitine palmitoyltransferase-1; FAS, fatty acid synthase; FASKO mice, mice...
- 4From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedLoss of cardiac myocytes in heart failure is thought to occur largely through an apoptotic process. Here we show that heart failure can also be precipitated through myocyte necrosis associated with [Ca.sup.2+] overload....
- 5From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedFamilial tumoral calcinosis is characterized by ectopic calcifications and hyperphosphatemia due to inactivatingmutations in FGF23 or UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase...
- 6From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedSince the effectiveness of androgen deprivation for treatment of advanced prostate cancer was first demonstrated, prevention strategies and medical therapies for prostate cancer have been based on understanding the...
- 7From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedExpression of eukaryotic translation initiation factor 4E (eIF4E) is commonly elevated in human and experimental cancers, promoting angiogenesis and tumor growth. Elevated eIF4E levels selectively increase translation of...
- 8From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-Reviewed
Myosin accumulation and striated muscle myopathy result from the loss of muscle RING finger 1 and 3.
Maintenance of skeletal and cardiac muscle structure and function requires precise control of the synthesis, assembly, and turnover of contractile proteins of the sarcomere. Abnormalities in accumulation of sarcomere... - 9From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedAlthough tumors express antigens that the immune system should respond to, they are not rejected by the immune system, which tolerates the tumor. Several mole- cules and cell types have been implicated in the induction...
- 10From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedAcute stimulation of cardiac β1-adrenergic receptors (β1ARs) by norepinephrine represents the strongest endogenous mechanism for increasing cardiac function, but long-term stimulation induces cardiomyocyte apoptosis and...
- 11From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedIt was previously appreciated that the determination of skeletal muscle fiber type (fast or slow) could be regulated by class II histone deacetylases (HDACs), which function by inhibiting the transcription factor myocyte...
- 12From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedTargeted disruption of a highly conserved distal enhancer reduces expression of the PU.1 transcription factor by 80% and leads to acute myeloid leukemia (AML) with frequent cytogenetic aberrations in mice. Here we...
- 13From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedAtaxia-telangiectasia mutated (ATM) kinase orchestrates nuclear DNA damage responses but is proposed to be involved in other important and clinically relevant functions. Here, we provide evidence for what we believe are...
- 14From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedMice lacking a specific distal upstream regulatory element (URE) that controls the level of expression of the gene encoding the transcription factor PU.1 have decreased expression of PU. 1 in the bone marrow and develop...
- 15From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedAdvances in our understanding of the skin immune system have a major impact on studies of skin autoimmunity, graft-versus-host disease, inflammation, and cancer as well as on the development of novel vaccines and...
- 16From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedAcknowledgments P.A. Marsden is a recipient of a Career Investigator Award from the Heart and Stroke Foundation of Canada and is supported by a grant from the Canadian Institutes of Health Research (CIHRMOP 37778)....
- 17From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedA small population of plasmacytoid DCs (pDCs) in mouse tumor-draining LNs can express the immunoregulatory enzyme indoleamine (2),(3)-dioxygenase (IDO). We show that these [IDO.sup.+] pDCs directly activate resting...
- 18From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedRecently, news headlines around the world rang out with the message that the world is losing the fight against AIDS. Those headlines were inspired by a talk given by Anthony Fauci, director of the National Institute of...
- 19From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedNonstandard abbreviations used: ACT1, actin; ACT1p, ACT1 promoter; LAmB, liposomal amphotericin B; MFC, minimum fungicidal concentration; MIC, minimum inhibitory concentration; PDA, potato dextrose agar; PDB, potato...
- 20From: Journal of Clinical Investigation. (Vol. 117, Issue 9) Peer-ReviewedClinical use of prostaglandin synthase-inhibiting NSAIDs is associated with the development of hypertension; however, the cardiovascular effects of antagonists for individual prostaglandin receptors remain...