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- 1From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedMutations in [Ca.sup.2+]-handling proteins in the heart have been linked to exercise-induced sudden cardiac death. The best characterized of these have been mutations in the cardiac [Ca.sup.2+] release channel known as...
- 2From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedA subset of CC chemokines, acting through CC chemokine receptors (CCRs) 1 to 5, is instrumental in shaping inflammatory responses. Recently, we and others have demonstrated that the atypical chemokine receptor D6...
- 3From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedCytochrome P450 1A1 (CYP1A1) is one of the most important detoxification enzymes due to its broad substrate specificity and wide distribution throughout the body. On the other hand, CYP1A1 can also produce highly...
- 4From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedCatecholamine-induced polymorphic ventricular tachycardia (CPVT) is a familial disorder caused by cardiac ryanodine receptor type 2 (RyR2) or calsequestrin 2 (CASQ2) gene mutations. To define how CASQ2 mutations cause...
- 5From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedMuscular dystrophies are often caused by mutations in cytoskeletal proteins that render cells more susceptible to strain-induced injury in mechanically active tissues such as skeletal or cardiac muscle. In this issue of...
- 6From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedErythrocyte precursors produce abundant α- and β-globin proteins, which assemble with each other to form hemoglobin A (HbA), the major blood oxygen carrier. αHb-stabilizing protein (AHSP) binds free α subunits reversibly...
- 7From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedProinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is expressed on sensory nerves to cause neurogenic inflammation. Transient receptor potential A1 (TRPA1) is an excitatory ion channel...
- 8From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedHepcidin is a peptide hormone secreted by the liver that plays a central role in the regulation of iron homeostasis. Increased hepcidin levels result in anemia while decreased expression is the causative feature in most...
- 9From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedWe have developed an integrated, multidisciplinary methodology, termed systems pathology, to generate highly accurate predictive tools for complex diseases, using prostate cancer for the prototype. To predict the...
- 10From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedThe article by Cohen and colleagues addresses a fundamental question in the cardiac stem cell field: What are the molecular pathways required for expansion and development of cardiac stem cells? The authors have...
- 11From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedNeutrophils contain antimicrobial peptides with antituberculous activity, but their contribution to immune resistance to tuberculosis (TB) infection has not been previously investigated to our knowledge. We determined...
- 12From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedGrb2-associated binder (Gab) family of scaffolding adaptor proteins coordinate signaling cascades downstream of growth factor and cytokine receptors. In the heart, among EGF family members, neuregulin-1β (NRG-1β, a...
- 13From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedOrganizations are defined by their missions. When they lose sight of them, they risk losing their identity and purpose. Developments in American academic medicine over the last several years point to a loss of focus on...
- 14From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedMutations in ras and p53 are the most prevalent mutations found in human nonmelanoma skin cancers. Although some p53 mutations cause a loss of function, most result in expression of altered forms of p53, which may...
- 15From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedThe role of the renin-angiotensin system has been investigated by overexpression or inactivation of its different genes in animals. However, there is no data concerning the effect of the constitutive activation of any...
- 16From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedNiemann-Pick C1-like 1 (NPC1L1) is required for cholesterol absorption. Intestinal NPC1L1 appears to be a target of ezetimibe, a cholesterol absorption inhibitor that effectively lowers plasma LDL-cholesterol in humans....
- 17From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedRecently, the small protein a hemoglobin-stabilizing protein (AHSP) was identified and found to specifically bind α-globin, stabilize its structure, and limit the toxic effects of excess α-globin, which are manifest in...
- 18From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedTumor radioresponsiveness depends on endothelial cell death, which leads in turn to tumor hypoxia. Radiation-induced hypoxia was recently shown to trigger tumor radioresistance by activating angiogenesis through...
- 19From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedSean B. Carroll W.W. Norton & Company. New York, New York, USA. 2006. 288 pp. $25.95. ISBN: 978-0-393-06163-5 (hardcover). Reviewed by David McKinnon Stony Brook University, Stony Brook, New York, USA. E-mail:...
- 20From: Journal of Clinical Investigation. (Vol. 117, Issue 7) Peer-ReviewedEndothelial protein C receptor (EPCR) and thrombomodulin (TM) are expressed at high levels in the resting microvasculature and convert protein C (PC) into its activated form, which is a potent anticoagulant and...