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- 1From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedGerald N. Callahan St. Martin's Press. New York, New York, USA. 2006. 304 pp. $24.95. ISBN: 978-0-312-34846-5 (hardcover). Reviewed by Ann M. Arvin Stanford University School of Medicine, Stanford, California, USA....
- 2From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedMutations in the key enzyme of sialic acid biosynthesis, uridine diphospho-N-acetylglucosamine 2-epimerase/N-acetylmannosamine (ManNAc) kinase (GNE/MNK), result in hereditary inclusion body myopathy (HIBM), an...
- 3From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2) isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels predict outcome in patients with acute myocardial...
- 4From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedAs of April 2007, Griffin P. Rodgers has taken over as director of the NIDDK, but had been the deputy director under Allen Spiegel since 2001 and the chief of Hematology since 1998. The JCI took the opportunity to ask...
- 5From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedInherited and acquired diseases of the hematopoietic system can be cured by allogeneic hematopoietic stem cell transplantation. This treatment strategy is highly successful when an HLA-matched sibling donor is available,...
- 6From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedInitial immune responses to allergens may occur before birth, thereby modulating the subsequent development of atopy. This paradigm remains controversial, however, due to the inability to identify antigen-specific T...
- 7From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedActivation of the inhibitor of NF-κB kinase/NF-κB (IKK/NF-κB) system and expression of proinflammatory mediators are major events in acute pancreatitis. However, the in vivo consequences of IKK activation on the onset...
- 8From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedK-Cl cotransport activity in rbc is a major determinant of rbc volume and density. Pathologic activation of erythroid K-Cl cotransport activity in sickle cell disease contributes to rbc dehydration and cell sickling. To...
- 9From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedHoloprosencephaly (HPE) is a clinically heterogeneous developmental anomaly affecting the CNS and face, in which the embryonic forebrain fails to divide into distinct halves. Numerous genetic loci and environmental...
- 10From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedRobert Austrian, the John Herr Musser Emeritus Professor of Research Medicine at the University of Pennsylvania School of Medicine and a leading figure in the prevention of pneumococcal diseases, died in Philadelphia on...
- 11From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedPPARγ is required for fat cell development and is the molecular target of antidiabetic thiazolidinediones (TZDs), which exert insulin-sensitizing effects in adipose tissue, skeletal muscle, and liver. Unexpectedly, we...
- 12From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedEndothelial progenitor cell (EPC) transplantation has beneficial effects for therapeutic neovascularization; however, only a small proportion of injected cells home to the lesion and incorporate into the neocapillaries....
- 13From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedThe ileal mucosa of Crohn disease (CD) patients is abnormally colonized by adherent-invasive E. coli (AIEC) that are able to adhere to and invade intestinal epithelial cells. Here, we show that CD-associated AIEC strains...
- 14From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedSingle gene mutations in β integrins can account for functional defects of individual cells of the hematopoietic system. In humans, mutations in [β.sub.2] integrin lead to leukocyte adhesion deficiency (LAD) syndrome and...
- 15From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedB cells from patients with common variable immunodeficiency (CVID) who are heterozygous for transmembrane activator and CAML interactor (TACI) mutation C104R, which abolishes ligand binding, fail to produce Igs in...
- 16From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedAtul Gawande Metropolitan Books. New York, New York, USA. 2007. 288 pp. $24.00. ISBN: 978-0-8050-8211-1 (hardcover). Reviewed by Ara Darzi and Oliver Warren Department of Biosurgery and Surgical Technology, St....
- 17From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedA new study by Galeano and colleagues in this issue of the JCI reports the first glomerular disease caused by a genetic defect in sialic acid biosynthesis (see the related article beginning on page 1585). Mice that...
- 18From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedIt is a rare privilege to stand in front of this group of distinguished physician-scientists today. I admit to feeling more than a little awed by this privilege for several reasons. First, as has been noted by many...
- 19From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedIncreasing evidence points to the central importance of enteric bacteria in the initiation of Crohn disease (CD). The ileal mucosa of CD patients is abnormally colonized by adherent-invasive E. coli (AIEC) that are able...
- 20From: Journal of Clinical Investigation. (Vol. 117, Issue 6) Peer-ReviewedAggrecan loss from cartilage in arthritis is mediated by aggrecanases. Aggrecanases cleave aggrecan preferentially in the chondroitin sulfate-2 (CS-2) domain and secondarily at the [E.sup.373]↓[.sup.374.A] bond in the...