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- 1From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedRetinoic acid receptors (RARs) are members of the nuclear hormone receptor family and regulate the proliferation and differentiation of multiple different cell types, including promyelocytic leukemia cells. Here we...
- 2From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedMutations in LMNA, which encodes nuclear Lamins A and C cause diseases affecting various organs, including the heart. We have determined the effects of an Lmna H222P mutation on signaling pathways involved in the...
- 3From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedThe politics of vaccination in twentieth-century America James Colgrove University of California Press. Berkeley, California, USA. 2006. 349 pp. $39.95. ISBN: 978-0-520-24749-3 (hardcover). Reviewed by Alan R....
- 4From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedThe adipose-derived hormone, leptin, acts via its receptor (LRb) to convey the status of body energy stores to the brain, decreasing feeding and potentiating neuroendocrine energy expenditure. The failure of high levels...
- 5From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedMetformin is among the most widely prescribed drugs for the treatment of type 2 diabetes. Organic cation transporter 1 (OCT1) plays a role in the hepatic uptake of metformin, but its role in the therapeutic effects of...
- 6From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedT cell-mediated autoimmune diseases such as multiple sclerosis and rheumatoid arthritis are driven by autoaggressive Th cells. The pathogenicity of such Th cells has, in the past, been considered to be dictated by their...
- 7From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedReceptor-mediated airway smooth muscle (ASM) contraction via [G.sub.αq], and relaxation via [G.sub.αs], underlie the bronchospastic features of asthma and its treatment. Asthma models show increased ASM [G.sub.αi]...
- 8From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedOne father's quest to help his daughter find her voice Teri Sforza with Howard Lenhoff and Sylvia Lenhoff Prometheus Books. Amherst, New York, USA. 2006. 296 pp. $24.00. ISBN: 978-1-59102-478-1 (hardcover). Reviewed...
- 9From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedTumors express antigens that should induce immune-mediated rejection, but spontaneous rejection of established tumors is rare. Recent work demonstrates that one reason for the lack of tumor rejection is that tumors...
- 10From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedAutosomal recessive cutaneous disorders, including various types of epidermolysis bullosa (EB), usually manifest shortly after birth. The clinical course of these diseases is often characterized by severe complications,...
- 11From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedGlucocorticoids (GCs) are widely used in the treatment of allergic skin conditions despite having numerous side effects. Here we use Cre/loxP-engineered tissue- and cell-specific and function-selective GC receptor (GR)...
- 12From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedTumors require a constant influx of myelomonocytic cells to support the angiogenesis and stroma remodeling needed for their growth. This is mediated by tumor-derived factors, which cause sustained myelopoiesis and the...
- 13From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedRyR2 is a [Ca.sup.2+] release channel expressed by cardiac muscle cells that has an important role in cardiac excitation-contraction coupling. In vitro studies have shown that calmodulin (CaM) inhibits RyR2 function, but...
- 14From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedMutations in presenilins are responsible for approximately 40% of all early-onset familial Alzheimer disease (FAD) cases in which a genetic cause has been identified. In addition, a number of mutations in presenilin-1...
- 15From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedPatients with Omenn syndrome (OS) have hypomorphic RAG mutations and develop varying manifestations of severe combined immunodeficiency. It is not known which symptoms are caused directly by the RAG mutations and which...
- 16From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedHow the fetus escapes rejection by the maternal immune system remains one of the major unsolved questions in transplantation immunology. Using a system to visualize both CD[4.sup.+] and CD[8.sup.+] T cell responses...
- 17From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedBecause of the large preexisting antigenic load and immunosuppressive environment within a tumor, inducing therapeutically useful antitumor immunity in cancer patients requires the development of powerful vaccination...
- 18From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedIt has been established that cancer can be promoted and/or exacerbated by inflammation and infections. Indeed, chronic inflammation orchestrates a tumor-supporting microenvironment that is an indispensable participant...
- 19From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedType 2 diabetes mellitus affects 9.6% of the adults in the United States and more than 200 million people worldwide. Diabetes can be a devastating disease, but it can now be treated with nine classes of approved drugs...
- 20From: Journal of Clinical Investigation. (Vol. 117, Issue 5) Peer-ReviewedLeptin is a regulator of energy homeostasis that acts in the CNS to tell the body that energy stores have been restocked and that it can stop feeding. Many individuals who are obese exhibit leptin resistance (an...