Showing Results for
- Academic Journals (35)
Search Results
- 35
Academic Journals
- 35
- Search Terms:
- 1From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedAlthough ras is a potent mitogenic oncogene, its tumorigenicity depends on cellular context and cooperative events. Here we show that low-level expression of a constitutively active Ha-ras in mouse urothelium induces...
- 2From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedIn response to ER stress, the pancreatic endoplasmic reticulum kinase (PERK) coordinates an adaptive program known as the integrated stress response (ISR) by phosphorylating the α subunit of eukaryotic translation...
- 3From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedThe most common pathology associated with obesity is insulin resistance, which results in the onset of type 2 diabetes mellitus. Several studies have implicated the mammalian target of rapamycin (mTOR) signaling pathway...
- 4From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedActivating EGFR mutations occur in human non-small cell lung cancer (NSCLC), with 5% of human lung squamous cell carcinomas having EGFRvIII mutations and approximately 10%-30% of lung adenocarcinomas having EGFR kinase...
- 5From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedAfter Dolly The uses and misuses of human cloning Ian Wilmut and Roger Highfield W.W. Norton & Co. New York, New York, USA. 2006. 336 pp. $24.95. ISBN: 978-0-393-06066-9 (hardcover). Reviewed by Robert Lanza...
- 6From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedHematopoietic stem cells are resistant to HIV-1 infection. Here, we report a novel mechanism by which the cyclin-dependent kinase inhibitor (CKI) p[21.sup.Waf1/Cip1/Sdi1] (p21), a known regulator of stem cell pool size,...
- 7From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedOn December 2, 2006, Pfizer halted the development of torcetrapib, the drug that was once considered by the company and pharmaceutical analysts as the most promising drug in its pipeline. The development of torcetrapib...
- 8From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedEnteropathogenic E. coli (EPEC) is a major cause of infantile diarrhea, but the pathophysiology underlying associated diarrhea is poorly understood. We examined the role of the luminal membrane [Cl.sup.-]/O[H.sup.-]...
- 9From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedIdiopathic hypogonadotropic hypogonadism (IHH) due to defects of gonadotropin-releasing hormone (GnRH) secretion and/or action is a developmental disorder of sexual maturation. To date, several single-gene defects have...
- 10From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedAutophagy is a lysosome-dependent degradative pathway frequently activated in tumor cells treated with chemotherapy or radiation. Whether autophagy observed in treated cancer cells represents a mechanism that allows...
- 11From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedIt has become increasingly obvious that the notion of a terminally differentiated cell is likely a simplified concept. Epithelial-mesenchymal transition (EMT), during which epithelial cells assume a mesenchymal...
- 12From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedEpithelial-mesenchymal transition (EMT) is an important mechanism for phenotypic conversion in normal development and disease states such as tissue fibrosis and metastasis. While this conversion of epithelia is under...
- 13From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedIntelligent thought Science versus the intelligent design movement John Brockman, editor Vintage. New York, New York, USA. 2006. 272 pp. $14.00. ISBN: 0-307-27722-4 (paperback). Reviewed by Gary Koretzky...
- 14From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedThe cardiac outflow tract develops as a result of a complex interplay among several cell types, including cardiac neural crest cells, endothelial cells, and cardiomyocytes. In both humans and mice, mutations in...
- 15From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedPseudomonas aeruginosa, an important cause of opportunistic infections in humans, delivers bacterial cytotoxins by type III secretion directly into the host cell cytoplasm, resulting in disruption of host cell signaling...
- 16From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedMuch has changed in the 5 years since the responsibility for editing the JCI was transferred to Columbia University. Wars and a hurricane have conspired with other factors to overwhelm the national treasury. Support for...
- 17From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedObesity and type 2 diabetes are associated with chronic inflammation. Adiponectin is an adipocyte-derived hormone with antidiabetic and antiinflammatory actions. Here, we demonstrate what we believe to be a previously...
- 18From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedThe role of the cystic fibrosis transmembrane conductance regulator (CFTR) as a cAMP-dependent chloride channel on the apical membrane of epithelia is well established. However, the processes by which CFTR is regulated...
- 19From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedDepleting host immune elements with nonmyeloablative regimens prior to the adoptive transfer of tumor-specific CD[8.sup.+] T cells significantly enhances tumor treatment. In the current study, superior antitumor efficacy...
- 20From: Journal of Clinical Investigation. (Vol. 117, Issue 2) Peer-ReviewedScientific discovery occasionally occurs as a sudden and dramatic leap ahead but more often proceeds at a subtler and steadier pace. Each small step forward may escape public notice but is ultimately vital to the...