Showing Results for
- Academic Journals (35)
Search Results
- 35
Academic Journals
- 35
- Search Terms:
- 1From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedGenetic defects in LDL clearance result in severe hypercholesterolemia and premature atherosclerosis. Mutations in the LDL receptor (LDLR) cause familial hypercholesterolemia (FH), the most severe form of genetic...
- 2From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedThe association between chronic inflammation and cancer is now well established. This association has recently received renewed interest with the recognition that microbial pathogens can be responsible for the chronic...
- 3From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedOver the past few decades, corticotropin-releasing factor (CRF) signaling pathways have been shown to be the main coordinators of the endocrine, behavioral, and immune responses to stress. Emerging evidence also links...
- 4From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedAntagonists of β-adrenergic receptors (β-ARs) have become a main therapeutic regimen for the treatment of heart failure even though the mechanisms of their beneficial effects are still poorly understood. Here, we used...
- 5From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedPaget disease is the most exaggerated example of abnormal bone remodeling, with the primary cellular abnormality in the osteoclast. Mutations in the p62 (sequestosome 1) gene occur in one-third of patients with familial...
- 6From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedIncreased insulin secretion and expansion of pancreatic β cell mass work together to maintain normal glucose levels when insulin resistance develops. Changes in glucose concentration have long been known to have profound...
- 7From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedMonocytes participate critically in atherosclerosis. There are 2 major subsets expressing different chemokine receptor patterns: CCR[2.sup.+]CX3CR[1.sup.+]Ly-6[C.sup.hi] and CCR2-CX3CR[1.sup.++]Ly-6[C.sup.lo] monocytes....
- 8From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedTGF-β functions as a tumor suppressor during the early stages of breast cancer, but high levels of TGF-β during the later stages of disease are associated with poor prognosis. Dong and colleagues set out to investigate...
- 9From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedWe examined the role of hepatic heparan sulfate in triglyceride-rich lipoprotein metabolism by inactivating the biosynthetic gene GlcNAc N-deacetylase/N-sulfotransferase 1 (Ndst1) in hepatocytes using the Cre-loxP...
- 10From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedPancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine stimuli and share many features with their...
- 11From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedMacrophages are present as resident cells in adipose tissue, and blood monocytes are recruited in increased numbers to sites of lipid accumulation in atherosclerosis, a modified form of inflammation in the arterial wall....
- 12From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedThe gastrointestinal (GI) tract is composed of a diverse set of organs that together receive extracorporeal nutrition and convert it to energy substrates and cellular building blocks. In the process, it must sort through...
- 13From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedThe forkhead box m1 (Foxm1) transcription factor is essential for initiation of carcinogen-induced liver tumors; however, whether FoxM1 constitutes a therapeutic target for liver cancer treatment remains unknown. In this...
- 14From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedT cell-produced cytokines play a pivotal role in the bone loss caused by inflammation, infection, and estrogen deficiency. IFN-γ is a major product of activated T helper cells that can function as a pro- or...
- 15From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedWe identified cellular and molecular mechanisms within the stem cell niche that control the activity of colonic epithelial progenitors (ColEPs) during injury. Here, we show that while WT mice maintained ColEP...
- 16From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedThe transcription factor forkhead box M1 (FoxM1) has been shown previously to be required for tumor initiation in a mouse model of hepatocellular carcinoma (HCC). Using this model of HCC, in which diethylnitrosamine is...
- 17From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedMacrophage accumulation participates decisively in the development and exacerbation of atherosclerosis. Circulating monocytes, the precursors of macrophages, display heterogeneity in mice and humans, but their relative...
- 18From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedAfter intestinal injury, both the number and type of intestinal epithelial cells must be restored. Intestinal stem cells, located at the base of the intestinal crypt, repopulate the depleted crypt in a process known as...
- 19From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedMarkers of oxidative damage have been detected in brain tissue from patients with Alzheimer disease (AD) and other neurodegenerative disorders. These findings implicate oxidative injury in the neurodegenerative process,...
- 20From: Journal of Clinical Investigation. (Vol. 117, Issue 1) Peer-ReviewedGlucokinase (Gck) functions as a glucose sensor for insulin secretion, and in mice fed standard chow, haplo-insufficiency of β cell-specific Gck (Gc[k.sup.+/-]) causes impaired insulin secretion to glucose, although the...