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- 1From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-Reviewed2003 September 12-16 September, Fri-Tue. Global Aspects of Technology Transfer: Biotechnology. Big Sky, Montana. Information: Gordon Research Conferences, PO Box 984, West Kingston, RI 02892-0984 USA, 401-783-4011,...
- 2From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedAlthough the mechanisms underlying benzene-induced toxicity and leukemogenicity are not yet fully understood, they are likely to be complicated by various pathways, including those of metabolism, growth factor...
- 3From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedAnalyzing Microarray Gene Expression Data Geoffrey J. McLachlan, Kim-Anh Do Hoboken, NJ:John Wiley & Sons, 2003. 320 pp. ISBN: 0-471-22616-5, $89.95 Annual Review of Genomics and Human Genetics Eric Lander, ed. Palo...
- 4From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedThis program announcement (PA) solicits novel research integrating genetics, behavior and aging. Human and non-human studies are needed to advance our understanding of the genetic and environmental influences and...
- 5From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedImagine being able to walk into your doctors office and present a "smart card" encoded either with the sequence of your genome itself or with an access code granting permission to log on to a secure database containing...
- 6From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedIn the United States, much of the pharmacogenetics research sponsored by the federal government is overseen by the Pharmacogenetics Research Network (PGRN). Formed three years ago, the PGRN is based at the National...
- 7From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedToxicoproteomics is the use of global protein expression technologies to better understand environmental and genetic factors, both in episodes of acute exposure to toxicants and in the long-term development of disease....
- 8From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedNewborns produce substantially less of the enzyme paraoxonase-1 (PON1)--which detoxifies organophosphate pesticides--than do adults, potentially leaving them more vulnerable to organophosphate exposures. Genetic...
- 9From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedIndividual variability in human arsenic metabolism has been reported frequently in the literature. This variability could be an underlying determinant of individual susceptibility to arsenic-induced disease in humans....
- 10From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedYou can call it metabolic profiling, metabonomics, or metabolomics; one speaker at a recent conference called it "biochemistry grown up." Scientists aren't settled on exactly what to call it, but this addition to the...
- 11From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedIn the world of cancer, early detection is critical for successful treatment, but early diagnostic tools are in woefully short supply. Among ovarian cancer patients, for example, 80% of cancers are diagnosed at a late...
- 12From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedIt is recognized that between two-percent and five-percent of all live-born infants have a major developmental defect. Approximately 40-percent of these defects are thought to be due to the effect(s) of an adverse...
- 13From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedEdited by Lucio G. Costa and Clement E. Furlong Boston, MA: Kluwer Academic, 2002. 216 pp. ISBN: 1-4020-7282-1, $95 cloth. Paraoxonase (PON1) in Health and Disease: Basic and Clinical Aspects is a complete and timely...
- 14From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedPON1 (paraoxonase-1) detoxifies organophosphates by cleavage of active oxons before they have a chance to inhibit cholinesterases. The corresponding gene PON1 has common polymorphisms in both the promoter (-909, -162,...
- 15From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedHave you ever heard someone try to dispel concern about their smoking by describing elderly relatives who were lifelong smokers? This gambit usually fails, but there actually is something to the excuse. Increasingly,...
- 16From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedBenzene is both widely used and widely studied. Yet, although the chemical is strongly associated with leukemia in humans, questions remain regarding its mechanism of action. Hoping to better understand the genetic...
- 17From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedThe National Institute on Alcohol Abuse and Alcoholism (NIAAA) is seeking research grant applications on the role of gene-environment interactions underlying susceptibility to alcohol-related phenotypes including...
- 18From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedIt is now well established that significant interindividual variability exists in the disposition and pharmacologic effects of certain medications. Influences such as environmental exposures, nutritional status,...
- 19From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedLong-term arsenic exposure is associated with an increased risk of vascular diseases including ischemic heart disease, cerebrovascular disease, and carotid atherosclerosis. The pathogenic mechanisms of arsenic...
- 20From: Environmental Health Perspectives. (Vol. 111, Issue 11) Peer-ReviewedMore than 100 scientists, public health professionals, and physicians gathered in Boston 7-9 June 2003 for a symposium, Genes, Environment, and Disease, that provided research updates on the NIEHS Environmental Genome...