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- 1From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedMost proteins that are destined for secretion follow the highly conserved secretory pathway from the endoplasmic reticulum (ER) to the Golgi, and then to the cell surface by a carrier vesicle. Proteins lacking a signal...
- 2From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedKomatsu, M. et al. Nature Cell Biol. 12, 213-223 (2010) p62 targets specific cargos for degradation by autophagy. When autophagy is impaired, p62 accumulates with toxic protein aggregates, and this has been...
- 3From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedThe origin of haematopoietic stem cells (HSCs) has been the subject of intense debate in the past few years. Some studies suggest that HSCs derive from endothelial cells, whereas others support that HSCs arise from the...
- 4From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedMeinecke, M. et al. Nature Cell Biol. 12, 273-277 (2010) The peroxisomal protein import machinery is unique because it allows the passage of folded and oligomerized proteins into the peroxisome. Meinecke et al. now...
- 5From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedFor over a decade, the actin-related protein 2/3 (ARP2/3) complex, a handful of nucleation-promoting factors and formins were the only molecules known to directly nucleate actin filament formation de novo. However, the...
- 6From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedAnyone researching cell adhesion and motility knows about focal adhesions --actin filament and integrin-rich molecular assemblies that mediate cell attachment to the extracellular matrix (ECM) and cell migration over...
- 7From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedAgarwal, S. et al. Nature 17 Feb 2010 (doi:10.1038/nature08792) Induced pluripotent stem cells show prolonged self-renewal, which is accompanied by telomere elongation in both mice and humans. Does this mean that...
- 8From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedRNA interference (RNAi) pathways mediate gene silencing by promoting translational inhibition or RNA degradation, and also act at the DNA level by repressing transposon activity and promoting the assembly of...
- 9From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedZhao, S. et al. Science 327, 1000-1004 (2010) Lys acetylation in the nucleus modifies histones and regulators of transcription. To investigate the non-nuclear functions of protein acetylation, Zhao et al. analyzed...
- 10From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedSpecialized membrane domains are an important feature of almost all cells. In particular, they are essential to tissues that have a highly organized cell cortex, such as the intestinal brush border epithelium. The ERM...
- 11From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedThe ability to repair damaged tissues is essential for metazoans, but the cellular and molecular events that initiate this process are unclear. Li et al. now report a role for cell death in wound healing and tissue...
- 12From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedNeurodegenerative diseases are commonly associated with the accumulation of intracellular or extracellular protein aggregates. Recent studies suggest that these aggregates are capable of crossing cellular membranes and...
- 13From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedHistones wrap DNA to form nucleosome particles that compact eukaryotic genomes. Variant histones have evolved crucial roles in chromosome segregation, transcriptional regulation, DNA repair, sperm packaging and other...
- 14From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedThe oxidant hydrogen peroxide ([H.sub.2][O.sub.2]) is a by-product of normal cellular processes that, as it is damaging to cells, is normally inactivated by detoxifying enzymes such as peroxiredoxins. In mammalian...
- 15From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedStrongly conserved but of unknown function, orosomucoid (Orm) family proteins (encoded by Orm and Ormdl genes) are implicated in the development of childhood asthma. For example, single nucleotide polymorphisms that are...
- 16From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-Reviewed
Stc1: a critical link between RNAi and chromatin modification required for heterochromatin integrity
Bayne, E. H. et al. Cell 140, 666-677 (2010) RNA interference pathways can promote the assembly of heterochromatin. In fission yeast, heterochromatin, which is characterized by histone H3 Lys9 (H3K9) methylation, is... - 17From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedCell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby contributing to embryonic development...
- 18From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedDuring mitosis, sister chromatids are anchored to the mitotic spindle (microtubules originating from spindle poles) at their centromere by kinetochores. Microtubules can also be generated at kinetochores, although their...
- 19From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedWelman, A. J. Biol. Chem. 5 Feb 2010 (doi:10.1074/jbc.M110.102392) Welman et al. report on the development of a two-colour photoactivatable probe called photoactivatable green cherry ([G.sup.PA]C). In live cells,...
- 20From: Nature Reviews Molecular Cell Biology. (Vol. 11, Issue 4) Peer-ReviewedMicroRNAs (miRNAs) are integral elements in the post-transcriptional control of gene expression. After the identification of hundreds of miRNAs, the challenge is now to understand their specific biological function....