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- 1From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedInvading mycobacteria are engulfed by macrophages, whereupon bacterial spreading is commonly thought to be restricted by the formation of immune-cell granulomas. in Science, Ramakrishnan and colleagues show that...
- 2From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedViral dissemination requires the release of newly synthesized virions from hijacked cells. In Cell, Bieniasz and colleagues report how tetherin, an interferon-inducible protein, blocks the release of HIV and other...
- 3From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedThe news regarding the finances of the 'Golden State' has been anything but sunny of late. Like other state and national governments hit hard by the recent global economic recession, California has faced tremendous...
- 4From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedTGF-[beta] triggers the phosphorylation and activation of Smad2 or Smad3 signaling adaptors, which translocate to the nucleus to regulate gene transcription. The TGF-[beta]--Smad axis influences several key immune-cell...
- 5From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedVoltage-gated proton currents regulate generation of reactive oxygen species (ROS) in phagocytic cells. In B cells, stimulation of the B cell antigen receptor (BCR) results in the production of ROS that participate in B...
- 6From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedCD44 expressed by activated T cells mediates adhesion, but whether CD44 has other physiological functions in activated T cells remains unclear. In Immunity, Baaten et al. use an influenza infection model to show that...
- 7From: Nature Immunology. (Vol. 11, Issue 3) Peer-Reviewed
Regulation of hematopoietic stem cell differentiation by a single ubiquitin ligase-substrate complex
Hematopoietic stem cell (HSC) differentiation is regulated by cell-intrinsic and cell-extrinsic cues. In addition to transcriptional regulation, post-translational regulation may also control HSC differentiation. To... - 8From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedAutoreactive [CD4.sup.+] T cells are involved in the pathogenesis of many autoimmune diseases, but the antigens that stimulate their responses have been difficult to identify and in most cases are not well defined. In...
- 9From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedCells commit to the regulatory T cell ([T.sub.reg] cell) lineage by upregulating the transcription factor Foxp3 in the thymus or periphery. in Nature, Rudensky and colleagues show that distinct conserved noncoding DNA...
- 10From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedCTL-mediated target cell killing requires polarization of the microtubule-organizing center (MTOC) and cytotoxic granules toward the target cell interface. In Immunity, groups led by Griffiths and Sykulev shed light on...
- 11From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedCommitment to the CD4 or CD8 T cell lineage requires T cell antigen receptor (TCR) signaling at the positive-selection checkpoint of thymocyte development. The lineage 'choice' is enforced by mutually inhibitory...
- 12From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedIL-10 exerts its anti-inflammatory effect through direct transcriptional control of cytokine expression as well as indirect modulation of the costimulatory properties of antigen-presenting cells. In the Proceedings of...
- 13From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedThe physiological regulation of the expression of interleukin (IL)-9, a cytokine traditionally regarded as being [T.sub.H]2 associated, remains unclear. Here, we show that IL-9-expressing T cells generated in vitro in...
- 14From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedNatural killer T cells (NKT cells) are CD1d-restricted, lipid antigen-reactive, immunoregulatory T lymphocytes that can promote cell-mediated immunity to tumors and infectious organisms, including bacteria and viruses,...
- 15From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedIt has been shown that human T cell leukemia virus type 1 (HTLV-1) can be transmitted between T cells through the formation of virological synapses. In Nature Medicine, Thoulouze and colleagues now show that...
- 16From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedMacrophages engulf apoptotic cells to prevent immune responses to self antigens. In Nature Medicine, Chawla and colleagues show that PPAR-[delta], a sensor of fatty acids, is essential for efficient macrophage...
- 17From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedE proteins are basic helix-loop-helix transcription factors that regulate many key aspects of lymphocyte development. Thymocytes express multiple E proteins that are thought to provide cooperative and compensatory...
- 18From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedChronic or unresolved inflammation can lead to tissue damage or, during sepsis, to death. In Nature, Serhan and colleagues characterize a potent anti-inflammatory molecule, resolvin D2, which is naturally produced by...
- 19From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedForty-five years ago Berken and Benacerraf published the first description of a class of membrane receptors that demonstrated specificity for the crystallizable fragment (Fc) of immunoglobulin G (IgG) (1). These...
- 20From: Nature Immunology. (Vol. 11, Issue 3) Peer-ReviewedAlthough ubiquitin-mediated degradation of proteins has long been known to regulate important cellular processes, only recently have researchers begun to address the role of this system in the context of hematopoietic...