Showing Results for
- Academic Journals (25)
Search Results
- 25
Academic Journals
- 25
- Search Terms:
- 1From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedAlthough many proteins can misfold into a self-seeding amyloid-like conformation (1), only six are known to be infectious, that is prions. The prions [Ψ.sup.+]], [[PIN.sup.+]], [URE3], [[SWI.sup.+]] and [HET-s] cause...
- 2From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedMutations in the CCM2 (cerebral cavernous malformation) gene leads to enlarged thin-walled blood vessels, but the function of this putative adaptor protein is unknown. Two studies in Nature Medicine demonstrate a role of...
- 3From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedThe growth of daughter cells in budding yeast is a classic model for investigating mechanisms involved in asymmetric cell division. an unexpected collaboration between the dead-box protein dbp5 and the nuclear transport...
- 4From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedCancer cells frequently undergo a shift from oxidative to glycolytic metabolism (1). Although there is interest in targeting metabolism as a form of cancer therapy, this area still remains in its infancy. Using cells,...
- 5From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedInflux of [Ca.sup.2+] through store-operated [Ca.sup.2+] channels (SOCs) is a central component of receptor-evoked [Ca.sup.2+] signals (1). Orai channels are SOCs (2-4) that are gated by STIM1, a [Ca.sup.2+] sensor...
- 6From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedHeterochromatin is a structurally compacted region of chromosomes in which transcription and recombination are inactivated (1,2). DNA replication is temporally regulated in heterochromatin, but the molecular mechanism...
- 7From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedThe small guanosine triphosphatase Ran loaded with GTP (RanGTP) can stimulate assembly of the type V intermediate filament protein lamin B into a membranous lamin B spindle matrix, which is required for proper...
- 8From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedMicroRNAs are important regulators of gene expression that control both physiological and pathological processes such as development and cancer. Although their mode of action has attracted great attention, the principles...
- 9From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedActivation of the protein kinases ATM and ATR following chromosomal breakage prevents initiation of DNA replication and entry into mitosis. However, the effects of ATM and ATR activation in cells already progressing...
- 10From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedFrizzled receptors regulate cell fate decisions and planar cell polarity by means of distinct intracellular effectors. The choice between these two signalling outputs may involve a pH-dependent interaction between...
- 11From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedChfr is a ubiquitin ligase that functions in the mitotic checkpoint by delaying entry into metaphase in response to mitotic stress (1,2). It has been suggested that Chfr is a tumour suppressor as Chfr is frequently...
- 12From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedAutophagy, long viewed as a bulk catabolic pathway, was recently implicated in the selective degradation of damaged organelles such as the endoplasmic reticulum and mitochondria. Zhang and colleagues have now found that...
- 13From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedRho GTPases control cytoskeletal dynamics through cytoplasmic effectors and regulate transcriptional activation through myocardin-related transcription factors (MRTFs), which are co-activators for serum response factor...
- 14From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedThe morphological remodelling of neuronal dendritic spines is associated with synaptic plasticity. Remodelling is based on the rearrangement of actin filaments, which are predominantly concentrated in the spines, whereas...
- 15From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedExport of messenger RNA from the transcription site in the nucleus and mRNA targeting to the translation site in the cytoplasm are key regulatory processes in protein synthesis. In yeast, the mRNA-binding proteins Nab2p...
- 16From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedA study by Nagaraj and Bannerjee reveals crosstalk between several key developmental signalling pathways. They report that phyllopod (phyl), a transcriptional target of the epidermal growth factor receptor (EGFR)...
- 17From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedCHIP is a U-box-type ubiquitin ligase that induces ubiquitylation and degradation of its substrates, which include several oncogenic proteins (1-12). The relationship between CHIP and tumour progression, however, has not...
- 18From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedEpigenetic mechanisms participate in the regulation of gene transcription in eukaryotes. Two studies in yeast have revealed an additional mechanism for controlling global gene transcription that is based on an inherited...
- 19From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedHaematopoietic stem-progenitor cells (HSPCs) reside in the bone marrow niche, where interactions with osteoblasts provide essential cues for their proliferation and survival. Here, we use live-cell imaging to...
- 20From: Nature Cell Biology. (Vol. 11, Issue 3) Peer-ReviewedTumorigenesis is regulated by several mechanisms including signalling, transcription and DNA replication. now a cytoplasmic protein quality-control pathway is implicated in the suppression of breast cancer cell growth,...