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- 1From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedHow the cytokine Flt3L controls dendritic cell (DC) development via the common DC progenitor pathway, which generates plasmacytoid DCs and [CD8.sup.+] and [CD103.sup.+] conventional DCs, is poorly understood. In...
- 2From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedAdipose tissue macrophages elicit proinflammatory cytokines that underlie insulin-resistant diabetes, a major contributor to chronic inflammation associated with obesity. In the EMBO Journal, Fan et al. show that the...
- 3From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedThe heterodimeric cytokine interleukin 27 (IL-27) signals through the IL-27R[alpha] subunit of its receptor, combined with gp130, a common receptor chain used by several cytokines, including IL-6. Notably, the IL-27...
- 4From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedThe maintenance of host integrity relies on the constant resetting of tissue homeostasis by regulatory networks. One cardinal feature of this regulation is associated with the ability of lymphocytes with constitutive or...
- 5From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedB lymphocytes differentiate into antibody-secreting cells under the antigen-specific control of follicular helper T cells ([T.sub.FH] cells). Here we demonstrate that isotype-switched plasma cells expressed major...
- 6From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedThe early embryonic development of many animals occurs outside the mother. A paper by Bosch and colleagues in the Proceedings of the National Academy of Sciences shows how such embryos survive this particularly...
- 7From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedCD1 activates T cells, but the function and size of the possible human T cell repertoires that recognize each of the CD1 antigen-presenting molecules remain unknown. Using an experimental system that bypasses major...
- 8From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedHow fair is peer review? Is it merely a means for scientists to block the presentation of competitors' research results to the community? Should peer review be more transparent? These are recurrent questions the...
- 9From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedDiseases preventable by underused vaccines cause the death of approximately 3 million children per year. The Global Alliance for Vaccines and Immunization (GAVI) was launched 10 years ago to tackle this appalling...
- 10From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedIn the absence of structural data, speculative models have been proposed to explain pre-TCR ligand-independent signaling and spontaneous dimerization on the cell surface. In Nature, Rossjohn and colleagues provide the...
- 11From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedHow the immune system discriminates between commensals and pathogens remains a hotly debated topic. In Cell Host & Microbe, Naglik and colleagues offer an answer to this question by looking at responses to Candida...
- 12From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedHepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed...
- 13From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedThe skin provides an efficient barrier that protects the organism from physical and chemical attack, as well as from the invasion of pathogens. Permeating both the outer and inner layers (epidermis and dermis), the...
- 14From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedLeading investigators working in the field of B lymphocytes and their colleagues once again gathered at the International Conference on B cells and Autoimmunity, held 19-21 August 2010 in Nara in the heart of Kansai,...
- 15From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedRegulatory T cells ([T.sub.reg] cells) have a critical role in the maintenance of immunological self-tolerance. Here we show that treatment of naive human or mouse T cells with IL-35 induced a regulatory population,...
- 16From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedThere are many examples in immunology of the assignment of names before function is thoroughly understood. As a result, the words or their definitions can get in the way of the field's ability to incorporate radical new...
- 17From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedIn 1962, as a second-year medical student at Stanford, I participated in the Fifth Tissue Homotransplantation Meeting of the New York Academy of Sciences. I had worked with Ernst Eichwald since high school and had shown...
- 18From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedMacrophages mediate crucial innate immune responses via caspase-l-dependent processing and secretion of interleukin 1[beta] (IL-l[beta]) and IL-18. Although infection with wild-type Salmonella typhimurium is lethal to...
- 19From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedNK cells confer innate immune functions. Von Andrian and colleagues show that hepatic NK cells bearing CXCR6 receptors confer antigen-specific NK cell memory that is protective against various viruses. Hepatic...
- 20From: Nature Immunology. (Vol. 11, Issue 12) Peer-ReviewedApproximately 10 million children under the age of 5 die each year. Of those, it is estimated that at least 3 million die of infectious diseases that are preventable with presently available but underused vaccines....