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- 1From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedGenome-wide association (GWA) studies have typically focused on the analysis of single markers, which often lacks the power to uncover the relatively small effect sizes conferred by most genetic variants. Recently,...
- 2From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedMechanisms of trinucleotide repeat instability during human Development Cynthia T. McMurray Nature Reviews Genetics 11, 786-799 (2010) In Table 1 in the above article, there was a mistake on the row starting...
- 3From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedMany mutations are neglected by studies of molecular evolution--in particular, the non-synonymous protein changes that are not known to have functional or fitness consequences. A systematic study of the functional...
- 4From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedHow does selection shape the genetic variation that influences quantitative traits? Most models assume that selection acts on the specific loci that affect the trait in question. But, according to a recent study in...
- 5From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedDenver, D. R. et al. Genome Res. 29 Oct 2010 (doi:10.1101/gr. 108191.110) A new study represents the first molecular characterization of adaptive recovery from deleterious mutations in a multicellular eukaryote. The...
- 6From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedGenomic rearrangements are associated with many human genomic disorders, including cancers. It was previously thought that most genomic rearrangements formed randomly but emerging data suggest that many are nonrandom,...
- 7From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedA major challenge in evolutionary biology and plant breeding is to identify the genetic basis of complex quantitative traits, including those that contribute to adaptive variation. Here we review the development of new...
- 8From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedFernandez-Tresguerres, B. et al. Proc. Natl Acad. Sci. USA 3 Nov 2010 (doi:10.1073/pnas.1010708107) This study suggests that the embryonic transcriptional network that is responsible for pluripotency is an...
- 9From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedA key goal of biology is to understand phenotypic characteristics, such as health, disease and evolutionary fitness. Phenotypic variation is produced through a complex web of interactions between genotype and...
- 10From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedLyko, F. et al. PLoS Biol. 8, e1000506 (2010) The authors have examined the distribution of methyl cytosine in the brains of queen and worker honeybees (Apis mellifera) to establish whether a unique brain DNA...
- 11From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedNext-generation sequencing is rapidly expanding our knowledge of genetic variation in crop plants. Recent resequencing studies in rice and maize illustrate the promise of this new phase of crop genomics to further our...
- 12From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedWe have become used to considering more than one gene at a time, so why not consider more than one trait at a time? And why not add in some environmental variation too? Yes, it's complicated, but two Reviews in this...
- 13From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedA new mechanism for variable penetrance has been uncovered by a study of the genomic binding of ATRX, a SWI/SNF family member that causes a human developmental disorder. This study also suggests intriguing links among...
- 14From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedAt fertilization, the paternal genome undergoes dramatic changes in its chromatin state, including the de novo establishment of epigenetic marks. By analysing pericentric heterochromatin (as a model for constitutive...
- 15From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedA cast of hundreds, if not quite thousands, of researchers worldwide have published their work on the pilot phase of the 1000 Genomes Project, building directly on the success of previous efforts of the Human Genome...
- 16From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedBenson, A. K. et al. Proc. Natl Acad. Sci, USA 11 Oct 2010 (doi:10.1073/ pnas.1007028107) Many vertebrates harbour gut microbiota, the composition of which depends on unknown environmental and host genetic factors....
- 17From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedUnlike animals, plants produce new organs throughout their life cycle using pools of stem cells that are organized in meristems. Although many key regulators of meristem and organ identities have been identified, it is...
- 18From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedTian, D., Sun, S. & Lee, J. T Cell 143, 390-403 (2010) Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice Shin, J. et al. Nature 467, 977-981 (2010) The long non-coding RNA (lncRNA)...
- 19From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedAlthough genome-wide association studies have identified markers that are associated with various human traits and diseases, our ability to predict such phenotypes remains limited. A perhaps overlooked explanation lies...
- 20From: Nature Reviews Genetics. (Vol. 11, Issue 12) Peer-ReviewedPitt, J. N & Ferre-DAmare, A, R. Science 330, 376-379 (2010) By using a combination of next-generation sequencing, computational analysis and in vitro selection, the authors have generated the first experimental...