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- Search Terms:ISSN: 1471003XAndISSN: 14710048AndVolume Number: 11AndIssue Number: 12AndStart Page: 787AndDate: 2010 Revise Search
- 1From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedThe axon initial segment (AIS) is a specialized neuronal compartment in which action potentials originate, and it has recently been shown to express [Ca.sup.2+] channels in addition to the classic [Na.sup.+] and...
- 2From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedEndocannabinoids are released by neurons and are generally thought to inhibit synaptic transmission in many brain regions, including the hippocampus. Recent studies showed that in this region, both neurons and...
- 3From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedMany pathogenic molecules underlying rare, mostly autosomal-dominant forms of Parkinson's disease have been identified. However, less is known about pathogenic pathways that lead to the common, 'sporadic' form. Now,...
- 4From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedThe right parietal lobe is involved in numerical cognition, but does stimulation of this area improve numerical abilities? Here, volunteers learned the relative value of arbitrary numerical symbols while receiving...
- 5From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedMajor depressive disorder (MDD) is associated with structural alterations to the hippocampus that are thought to underlie some symptoms of the disease, such as impaired cognition and depressed mood. However, the...
- 6From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedThe p53 tumour suppressor is inactivated in many cancers, but it is surprisingly still expressed in neuroblastoma. This paper showed that, in humans, such tumours silence p53 activity with the microRNA miR-380-5p. This...
- 7From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedEndothelial cells in the CNS are endowed with properties--such as tight junctions, low rates of transcytosis and the expression of various transporters--that allow them to regulate the movement of molecules, ions and...
- 8From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedSensory synapses of the visual and auditory systems must faithfully encode a wide dynamic range of graded signals, and must be capable of sustained transmitter release over long periods of time. Functionally and...
- 9From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedDeclarative and emotional memories are key to quality of life and day-to-day functioning. The absence of memory or the inability to recall memories properly in an emotional context leads to dysfunction but,...
- 10From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedMammalian cells contain cell-autonomous 'clocks', or sets of genes of which the cyclical expression controls processes governed by circadian rhythms. The task of ensuring that these millions of clocks are entrained (or...
- 11From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedThere is much debate as to the origin of microglial cells--the resident macrophages of the CNS--and it has been proposed that haematopoietic progenitor cells are recruited from the blood and differentiate in the CNS in...
- 12From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-Reviewed5-hydroxytryptamine 2C receptors (5-H[T.sub.2C]) in the brain regulate glucose homeostasis, but the underlying mechanisms are not known. Xu et al. generated mice that expressed 5-H[T.sub.2C]Rs only in neurons containing...
- 13From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedFollowing host infection, herpes simplex virus 1 (HSV-1) remains latent in peripheral neurons. [beta]-nerve growth factor (NGF) was known to have a role in maintaining HSV-1 latency, but the molecular details had not...
- 14From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedThe membrane protein Nogo-A was initially characterized as a CNS-specific inhibitor of axonal regeneration. Recent studies have uncovered regulatory roles of Nogo proteins and their receptors--in precursor migration,...
- 15From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedThe nucleus accumbens (NAc) is known to be important for the rewarding effects of cocaine, but little is known about how the subtypes of projection neurons in this region contribute to the effect. Now, Nestler and...
- 16From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedVisual images that we associate with a familiar concept activate neurons in the medial temporal lobe (MTL) that encode that concept. Now, Cerf, Koch, Fried and colleagues show that when multiple images are viewed...
- 17From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedParkinson's disease, like many common age-related conditions, is now recognized to have a substantial genetic component. Here, I discuss how mutations in a large complex gene--leucine-rich repeat kinase 2...
- 18From: Nature Reviews Neuroscience. (Vol. 11, Issue 12) Peer-ReviewedNeurons in the spinal dorsal horn process sensory information, which is then transmitted to several brain regions, including those responsible for pain perception. The dorsal horn provides numerous potential targets for...