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- 1From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Beth A Sullivan (corresponding author) [1, 2]; Gary H Karpen [1, 2] The flexible N-terminal tails of the four core histones (H2A, H2B, H3 and H4) undergo a range of post-translational modifications,...
- 2From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Daniel N Wilson [1]; Knud H Nierhaus [1] A cell from a higher eukaryote lives in homeostasis and is thus buffered against sudden changes in the environment. In contrast, a bacterial cell has to react...
- 3From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Nikolaus Pfanner (corresponding author) [1]; Nils Wiedemann [1]; Chris Meisinger (corresponding author) [1]; Trevor Lithgow [2] Mitochondria are not only of central importance for the bioenergetics of...
- 4From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Rhiannon R Penkert [1]; Heather M DiVittorio [1]; Kenneth E Prehoda (corresponding author) [1] Protein interaction domains form the backbone of cellular information flow [1]. The PDZ protein interaction...
- 5From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Fedor Kouzine [1]; Juhong Liu [1]; Suzanne Sanford [1]; Hye-Jung Chung [1]; David Levens (corresponding author) [1] Counter-rotation of the transcription machinery and template as DNA is threaded through the...
- 6From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Michelle Montoya Diacylglycerol is a lipid second messenger involved in cell signaling and phorbol esters are natural products that mimic that action. Diacylglycerol mediates signaling from a variety of...
- 7From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Antón Vila-Sanjurjo [1, 2, 3]; Barbara-S Schuwirth [1, 2, 3]; Cathy W Hau [1, 2]; Jamie H D Cate (corresponding author) [1, 2] All organisms contain stress response systems that allow them to survive...
- 8From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedVarious variants The nucleosome blocks the accessibility of DNA to transcription factors and passage of the transcription complex machinery. The cell has a few ways to overcome this barrier, including...
- 9From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Joshua S Weinger [1, 3]; K Mark Parnell [1, 3]; Silke Dorner [2]; Rachel Green [2]; Scott A Strobel (corresponding author) [1] The ribosome is the molecular machine responsible for protein synthesis in all...
- 10From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): B Trevor Sewell [1]; Robert B Best [1, 4]; Shaoxia Chen [2, 4]; Alan M Roseman [2, 4]; George W Farr [3]; Arthur L Horwich [3]; Helen R Saibil (corresponding author) [2] The chaperonin GroEL is an 800-kDa,...
- 11From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Karl-Magnus Larsson [1]; Albert Jordan [2, 4]; Rolf Eliasson [2]; Peter Reichard [2]; Derek T Logan (corresponding author) [3]; Pär Nordlund (corresponding author) [1] RNRs are found in all living cells and...
- 12From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedThe 2004 Nobel Prize in chemistry has been awarded to three biochemists. As stated in an announcement from the Royal Swedish Academy of Sciences on 6 November 2004, Aaron Ciechanover, Avram Hershko (both at the Israel...
- 13From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Michelle K Nahas [1]; Timothy J Wilson [2]; Sungchul Hohng [1]; Kaera Jarvie [2]; David M J Lilley (corresponding author) [2]; Taekjip Ha (corresponding author) [1] The nucleolytic ribozymes are among the...
- 14From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Matthew C Lorincz (corresponding author) [1]; David R Dickerson [1]; Mike Schmitt [2]; Mark Groudine [1, 2] The CpG dinucleotide is generally found at a lower than expected frequency in the mammalian genome,...
- 15From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Saumendra N Sarkar [1]; Kristi L Peters [1]; Christopher P Elco [1]; Shuji Sakamoto [2]; Srabani Pal [1]; Ganes C Sen (corresponding author) [1] Viral stress-inducible genes encode proteins that mediate the...
- 16From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Francisco J Asturias [1] Control of gene expression underlies cellular differentiation and development, and constitutes an essential checkpoint in signaling and oncogenesis. Therefore, functional and...
- 17From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Alan Rein [1] The genomic RNA of retroviruses, like that of many RNA viruses, leads a double life. On the one hand, the retroviral RNA must be incorporated into nascent virus particles in order to carry the...
- 18From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Scott Hauenstein [1]; Chun-Mei Zhang [2]; Ya-Ming Hou [2]; John J Perona (corresponding author) [1] Two general mechanisms control the discrimination of nucleic acid sequences by proteins. The first of...
- 19From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Michael S Cosgrove [1]; Jef D Boeke (corresponding author) [2, 3]; Cynthia Wolberger [1, 4] The organization of eukaryotic DNA into chromatin regulates whether proteins that mediate many essential cellular...
- 20From: Nature Structural and Molecular Biology. (Vol. 11, Issue 11) Peer-ReviewedAuthor(s): Matthew J Daniels [1]; Alexander Marson [1]; Ashok R Venkitaraman (corresponding author) [1] The PML protein is a target of the t(15;17) chromosomal translocation typical of promyelocytic variants of acute...