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- 1From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedNeutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity...
- 2From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedDendritic epidermal [gamma][delta] T cells (DETCs) reside in the skin, where they contribute to antimicrobial protection and wound healing, but how these DETCs are activated remains unknown. In Science, Havran and...
- 3From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedAfter being activated by antigen, helper T lymphocytes switch from a resting state to clonal expansion. This switch requires inactivation of the transcription factor Foxo1, a suppressor of proliferation expressed in...
- 4From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedInfections are countered by a variety of both constitutive and inducible innate defense mechanisms that limit the replication and spread of pathogens. The inducible components of innate defense rely on innate immune...
- 5From: Nature Immunology. (Vol. 11, Issue 11) Peer-Reviewed
The [S1P.sub.1]-mTOR axis directs the reciprocal differentiation of [T.sub.H]1 and [T.sub.reg] cells
Naive [CD4.sup.+] T cells differentiate into diverse effector and regulatory lineages to orchestrate immunity and tolerance. Here we found that the differentiation of proinflammatory T helper type 1 ([T.sub.H]1) cells... - 6From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedAfter 2 years of negotiations, debates and delays, September 2010 saw the European Parliament approve new legislation for the protection of laboratory animals. Member states have 2 years to implement the new rules. The...
- 7From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedFlow cytometry has historically not constituted a large segment of the monitoring assays in clinical trials. The technology tends to be complex and expensive and often uses idiosyncratic methods for instrument setup and...
- 8From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedMicroRNAs are important controllers of T cell homeostasis and function, including immunohomeostasis mediated by regulatory T cells ([T.sub.reg] cells). Rudensky and colleagues in Cell show that the microRNA miR-146a has...
- 9From: Nature Immunology. (Vol. 11, Issue 11) Peer-Reviewed[CD8.sup.+] T cells with innate-like features, including rapid production of IFN-[gamma] and IL-4, arise in mice lacking the Tec family kinases Itk and Rlk. In Immunity, Kee and colleagues report that iNKT cells that...
- 10From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedThe function of interleukin 37 (IL-37; formerly IL-1 family member 7) has remained elusive. Expression of IL-37 in macrophages or epithelial cells almost completely suppressed production of pro-inflammatory cytokines,...
- 11From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedPolymorphonuclear neutrophil leukocytes are commonly regarded as 'professional' phagocytic cells of the innate immune system. However, although neutrophils are the main effector cells in inflammation, they can also...
- 12From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedThe detection of intracellular microbial DNA is critical to appropriate innate immune responses; however, knowledge of how such DNA is sensed is limited. Here we identify IFI16, a PYHIN protein, as an intracellular DNA...
- 13From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedHow BCR complexes remain silent on resting B cells and how they are activated by ligands is poorly understood. The assumption at present is that resting B cells express monomeric, signaling-inert BCRs that are activated...
- 14From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedMany receptors that activate cells of the immune system are multisubunit membrane protein complexes in which ligand recognition and signaling functions are contributed by separate protein modules. Receptors and...
- 15From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedDefining where and in what form lymphocytes encounter antigen is fundamental to understanding how immune responses occur. Although knowledge of the recognition of antigen by [CD4.sup.+] and [CD8.sup.+] T cells has...
- 16From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedHistone demethylases are chromatin-modifying enzymes required for methylation removal and chromatin opening at specific promoters, but the mechanistic basis of their recruitment to particular gene loci remains poorly...
- 17From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedViral infection triggers innate immune sensors to produce type I interferon. However, infection of T cells and macrophages with human immunodeficiency virus (HIV) does not trip those alarms. How HIV avoids activating...
- 18From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedObesity is associated with resistance to leptin and insulin as well as a generalized proinflammatory status. In PLoS Biology, Carvalheira and colleagues make a direct link between exercise and the anti-inflammatory...
- 19From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedThe potent tumoricidal activity of interleukin 12 (IL-12) is thought to be mediated by the activation and polarization of natural killer (NK) cells and T helper type 1 ([T.sub.H]1) cells, respectively. By systematic...
- 20From: Nature Immunology. (Vol. 11, Issue 11) Peer-ReviewedTo the Editor: Newly cloned interleukin 1 (IL-1) family members (1-3) were originally given an IL-1 family (IL-1F) designation (4), but as functions have now been elucidated for several of these (5,6), we propose...