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- 1From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedTo the Editor, Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes, such as cell cycle or transcription, whose activity requires association with specific cyclin subunits....
- 2From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedAgeing results from complex genetically and epigenetically programmed processes that are elicited in part by noxious or stressful events that cause programmed cell death. Here, we report that administration of...
- 3From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedBlood vessels are formed from capillaries sprouting from existing vessels or de novo. A third way of forming new blood vessels is now described in Science (Science 326, 294-298; 2009). Stainier and colleagues show that...
- 4From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedStem cells (SCs) self-renew and generate differentiating progenitors through asymmetric cell division. Progenitors proliferate actively, whereas undifferentiated SCs remain mostly quiescent, except for undergoing...
- 5From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedAutophagy is an active homeostatic degradation process for the removal or turnover of cytoplasmic components wherein the LC3 ubiquitin-like protein undergoes an Atg7 E1-like enzyme/ Atg3 E2-like enzyme-mediated...
- 6From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedScholarly publication remains essential for describing and contextualizing findings, but it is inadequate as the only document of research activity. Most journals require a significant conceptual advance, and format...
- 7From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedThe response to DNA damage involves regulation of several essential processes to maximize the accuracy of DNA damage repair and cell survival (1). Telomerase has the potential to interfere with repair by inappropriately...
- 8From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedNature Cell Biol. 11, 1191-1196 (2009); published online 20 September 2009; corrected after print 5 October 2009 In the version of this letter initially published online and in print, the directions of the horizontal...
- 9From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedNature Cell Biol. 10, 460-467 (2008); published online 16 March 2008; corrected after print 1 October 2009 In the version of this letter initially published online and in print, the wrong image was displayed for Fig....
- 10From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedThe anaphase-promoting complex (APC/C), a ubiquitin ligase, is the target of the spindle-assembly checkpoint (SAC), and it ubiquitylates protein substrates whose degradation regulates progress through mitosis (1-3). The...
- 11From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedIntravital imaging demonstrates that TGF[beta] signalling regulates the mode of cancer cell motility. Cells with active TGF[beta] signaling migrate as single cells and are capable of hematogenous and lymphatic spread,...
- 12From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-Reviewed[gamma]-Secretase, an aspartyl protease that belongs to the iCLiPs (intramembrane cleaving proteases) family, is a multiprotein complex that consists of presenilin (PS), nicastrin (NCT), Aph-1 and Pen-2 (ref. 1). It is...
- 13From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedIdentifying therapies to slow down ageing and delay age-associated diseases is a primary goal of ageing-related research. Resveratrol and rapamycin were first found to promote longevity in yeast, and their effects were...
- 14From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedSlit-Roundabout (Robo) signalling has a well-understood role in axon guidance (1-5). Unlike in the nervous system, however, Slit-dependent activation of an endothelial-specific Robo, Robo4, does not initiate a guidance...
- 15From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedMutations of the ubiquitin ligase parkin account for most autosomal recessive forms of juvenile Parkinson's disease (AR-JP). Several studies have suggested that parkin possesses DNA-binding and transcriptional activity....
- 16From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedThe tumour suppressor Tip60 is a histone acetyltransferase implicated in transcriptional control and dna double-strand break repair. Tip60 binds to the heterochromatic histone mark H3K9me3, triggering acetylation and...
- 17From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedMost eukaryotic cells have a primary cilium which functions as a sensory organelle (1). Cilia are assembled by intraflagellar transport OFT), a process mediated by multimeric IFT particles and molecular motors (2). Here...
- 18From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedNo one knows what the future holds, but one thing is clear, everything changes. The best advice for a young scholar is to remain flexible and seek new experiences, unbound by past successes or failures. The temptation...
- 19From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedMetastasis is a complex multistep process, which requires the concerted action of many genes and is the primary cause of cancer death. Both pathways that regulate metastasis enhancement and those that regulate its...
- 20From: Nature Cell Biology. (Vol. 11, Issue 11) Peer-ReviewedProgrammed cell death (PCD) is executed by proteases, which cleave diverse proteins thus modulating their biochemical and cellular functions. Proteases of the caspase family and hundreds of caspase substrates constitute...