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- 1From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedAdjacent epithelial cells are connected by adherens junctions, which are multiprotein complexes containing E-cadherin. Both maintenance and remodelling of adherens junctions require E-cadherin dynamics but how this...
- 2From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedThe plant hormone auxin controls root epidermal cell development in a concentration-dependent manner (1-3). Root hairs are produced on a subset of epidermal cells as they increase in distance from the root tip. Auxin is...
- 3From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedCitations are an important component in the assessment of academic performance. Yet, the growing literature, combined with format constraints of journals, encourage citation of reviews in preference to primary research....
- 4From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedThe Morphogenesis and Cell Behaviour meeting held this fall in Barcelona explored the role of forces, adhesion and oscillations in embryonic morphogenesis. it highlighted the impact of new microscopy methods and...
- 5From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedTelomeres are essential for maintaining cellular proliferative capacity and their loss has been implicated in ageing. A key regulator in telomere maintenance is the telomeric protein TRF1, which was also identified as...
- 6From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedAt the end of cytokinesis, the dividing cells are connected by an intercellular bridge, containing the midbody along with a single, densely ubiquitylated, circular structure called the midbody ring (Mr) (1-3). recent...
- 7From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedMitochondria are often found near the endoplasmic reticulum (ER) but how these organelles are juxtaposed has been unclear. The mitochondrial GTPase Mfn2 has now been shown to control ER-mitochondrial tethering (Nature...
- 8From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedMutations in the E3 ubiquitin ligase Parkin are associated with the early onset of Parkinson's disease. How Parkin influences neuronal survival is unclear but its function has been linked to mitochondrial integrity....
- 9From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedOxygen deprivation (hypoxia) results in reprogrammed gene expression patterns that induce multifaceted cellular responses. Here we identify a regulated interaction between the serine/threonine kinase HIPK2 and the...
- 10From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedA number of signalling pathways have been identified that regulate apoptosis, but the mechanism that initiates apoptosis remains incompletely understood. We have found that the nuclear RanGTP level is diminished during...
- 11From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedThe long-term response (on a timescale of hours) of mammalian cells to injury by various kinds of extraneous, non-physiological insults, such as heating or exposure to toxic chemicals, has been widely studied and...
- 12From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedThe systems that refine actomyosin forces during motility remain poorly understood. Septins assemble on the T-cell cortex and are enriched at the mid-zone in filaments. Septin knockdown causes membrane blebbing, excess...
- 13From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedDynamic membrane repair and remodelling is an elemental process that maintains cell integrity and mediates efficient cellular function. Here we report that MG53, a muscle-specific tripartite motif family protein...
- 14From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedSecreted Frizzled-related proteins (sFRPs) are signalling molecules well-known as antagonists of the Wnt pathway, but recent studies indicate that they may have additional functions unrelated to Wnt. a new study...
- 15From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedSeptins comprise a conserved family of cytoskeletal proteins distinct from the microfilament, microtubule and intermediate filament systems. They are GTPases that have been implicated in a number of cellular processes...
- 16From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedWhen challenged by increased metabolic loads, precipitated, for example, by pregnancy or obesity, insulin-producing pancreatic β cells increase their mass to maintain systemic euglycemia. This expansion induces hypoxia...
- 17From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedIn animal cells, cytokinesis is powered by a contractile ring of actin filaments (F-actin) and myosin-2. Formation of the contractile ring is dependent on the small GTPase RhoA (1,2), which is activated in a precise zone...
- 18From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedDistinct modes of erK activation, sustained or transient, are essential for cell fate decision in cultured cells. Here we show that Xenopus laevis Sprouty2 (XSpry2) controls the duration of erK activity and thereby...
- 19From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedApoptosis is a highly regulated cell death program, essential for the development of multicellular organisms. Cells can receive specific signals to undergo or suppress apoptosis. These signals can be extrinsic through...
- 20From: Nature Cell Biology. (Vol. 11, Issue 1) Peer-ReviewedMost solid tumours are aneuploid and many frequently mis-segregate chromosomes. This chromosomal instability is commonly caused by persistent mal-oriented attachment of chromosomes to spindle microtubules. Chromosome...