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- 1From: BMC Biology. (Vol. 11) Peer-ReviewedBackground Human pluripotent stem cells (hPSCs) hold great promise for applications in regenerative medicine. However, the safety of cell therapy using differentiated hPSC derivatives must be improved through methods...
- 2From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Miranda Robertson Why yet another editorial on painless publishing and re-review opt-out? To summarize succinctly in one place all the issues, some quite contentious, that we areaware of in the light of...
- 3From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Sean Munro1 There is little risk of cell biologists' getting bored in the 21 st century, but it is worth considering a few of the questions they might hope to have solved by 2100, if not before....
- 4From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Brigitta Stockinger1 The cells of the immune system fall into two broad categories - innate and adaptive - with the cells of the innate immune system providing frontline defense by means of invariant...
- 5From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Jan Pawlowski1 Early metagenetic surveys of micro-eukaryotic diversity revealed numerous phylotypes that seemed unrelated to any described eukaryotic taxa. It has been proposed that some of them may...
- 6From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedBackground Some of the most marked temporal fluctuations in species abundances are linked to seasons. In theory, multispecies assemblages can persist if species use shared resources at different times, thereby...
- 7From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedBackground In the mouse ovary, oocytes initially develop in clusters termed germ-cell nests. Shortly after birth, these germ-cell nests break apart, and the oocytes individually become surrounded by somatic granulosa...
- 8From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedDuring 30 years of research on human immunodeficiency virus (HIV), our knowledge of its cellular receptors - CD4, CCR5 and CXCR4 - has illuminated aspects of the pathogenesis of the acquired immune deficiency syndrome...
- 9From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Roman H Khonsari1,2,15 , Maisa Seppala1,3 , Alan Pradel4 , Hugo Dutel5,6 , Gaël Clément5 , Oleg Lebedev7 , Sarah Ghafoor1 , Michaela Rothova1,8 , Abigael Tucker1 , John G Maisey4 , Chen-Ming Fan9 , Atsushi...
- 10From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedBackground A key to understanding the evolution of the nervous system on a large phylogenetic scale is the identification of homologous neuronal types. Here, we focus this search on the sensory and motor neurons of...
- 11From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Thomas LP Couvreur1,2 and William J Baker3 The biological diversity and complexity of tropical rain forests have fascinated biologists for centuries. This, the most species-rich terrestrial biome on Earth,...
- 12From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Bruce J Mayer1 The scientific community was deeply saddened by news of the untimely death of Tony Pawson, a member of the BMC Biology editorial board and a leader in the field of cell signaling. I first...
- 13From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Gillian M Griffiths1 There is nothing more frustrating than reaching the end of a jigsaw puzzle to find that some of the pieces are missing. There are certainly areas of immunology where the same problem...
- 14From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Virginia Walbot1 Genomics has given us a new appreciation for the many ways genes and genomes evolve At the turn of the millennium, the most we could hope for was a few small genomes completed and...
- 15From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedAuthor(s): Virginia Walbot1 When I wrote my 2009 comment 'Are we training pit bulls to review our manuscripts ?' [1] I was motivated by the aggressive search for flaws that we teach - yes it's our best defense...
- 16From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedBackground Inducible defenses are a common and widespread form of phenotypic plasticity. A fundamental factor driving their evolution is an unpredictable and heterogeneous predation pressure. This heterogeneity is...
- 17From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedBackground Subterranean blind mole rats (Spalax) are hypoxia tolerant (down to 3% O.sub.2), long lived (>20 years) rodents showing no clear signs of aging or aging related disorders. In 50 years of Spalax research,...
- 18From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedBackground ICE (Inducer of CBF Expression) family genes play an important role in the regulation of cold tolerance pathways. In an earlier study, we isolated the gene CdICE1 from Chrysanthemum dichrum and...
- 19From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedBackground The carbon metabolism of the blood stages of Plasmodium falciparum, comprising rapidly dividing asexual stages and non-dividing gametocytes, is thought to be highly streamlined, with glycolysis providing...
- 20From: BMC Biology. (Vol. 11, Issue 1) Peer-ReviewedBackground Juvenile hormone (JH) has been demonstrated to control adult lifespan in a number of non-model insects where surgical removal of the corpora allata eliminates the hormone's source. In contrast, little is...