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- 1From: Journal of Translational Medicine. (Vol. 11) Peer-ReviewedHeart failure is one of the key causes of morbidity and mortality world-wide. The recent findings that regeneration is possible in the heart have made stem cell therapeutics the Holy Grail of modern cardiovascular...
- 2From: Journal of Translational Medicine. (Vol. 11) Peer-ReviewedContributing reviewers The editor of Journal of Translational Medicine would like to thank all our reviewers who have contributed to the journal in Volume 10 (2012). Author(s): Francesco Marincola1 MichaÅ...
- 3From: Journal of Translational Medicine. (Vol. 11) Peer-ReviewedBackground B cell malignancies are characterized by clonal expansion of B cells expressing tumor-specific idiotypes on their surface. These idiotypes are ideal target antigens for an individualized immunotherapy....
- 4From: Journal of Translational Medicine. (Vol. 11) Peer-ReviewedBackground Primary testicular lymphoma (PTL) is a rare and lethal disease. The most common histological subtype is diffuse large B-cell lymphoma (DLBCL). Standard treatments are frequently ineffective. Thus, the...
- 5From: Journal of Translational Medicine. (Vol. 11) Peer-ReviewedBackground Patients with B cell malignancies refractory to allogeneic stem cell transplantation (SCT) can be treated by subsequent immunotherapy with donor lymphocyte infusions (DLI). But unlike myeloid leukemia, B...
- 6From: Journal of Translational Medicine. (Vol. 11) Peer-ReviewedBackground Recently, the high-mobility group A1 gene (HMGA1) variant IVS5-13insC has been associated with type 2 diabetes, but reported associations are inconsistent and data are lacking in Hispanic and African...
- 7From: Journal of Translational Medicine. (Vol. 11) Peer-ReviewedBackground Diabetes mellitus is affecting more than 300 million people worldwide. Current treatment strategies cannot prevent secondary complications. Stem cells due to their regenerative power have long been the...
- 8From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground Ascorbic acid (vitamin C, ascorbate) is a key water soluble antioxidant that, when administered in doses well above its recommended dietary allowance, may have preventative and therapeutic value against a...
- 9From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground The cell division cycle 20 homolog (CDC20) is an essential cofactor of the anaphase-promoting complex (APC/C). CDC20 overexpression has been detected in many types of human cancers; however, its clinical...
- 10From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground Hearing loss is caused by several environmental and genetic factors and the proportion attributed to inherited causes is assumed at 50 ~ 60% . Mutations in GJB2 and mitochondrial DNA (mtDNA) 12S rRNA are...
- 11From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground The prevalence of vitamin D deficiency among patients with cancer has been previously reported. Because vitamin D is fat soluble, patients with pancreatic adenocarcinoma may have an especially high risk of...
- 12From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground Modified cell-based angiogenic therapy has become a promising novel strategy for ischemic heart and limb diseases. Most studies focused on myoblast, endothelial cell progenitors or bone marrow mesenchymal...
- 13From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground The [alpha].sub.2-adrenoreceptor agonist dexmedetomidine is known to provide renoprotection against ischemia and reperfusion (I/R) injury. However the underlying molecular mechanisms remain unclear. The...
- 14From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground CD8+ T cells are key members of adaptive immunity against tumorigenesis. As subset of CD8+ T cells, effector T cells (Te) and memory T cells (Tm) have different biological activities. The former can kill...
- 15From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground Ischemia/reperfusion injury plays a crucial role in renal transplantation, and represents a significant risk factor for acute renal failure and delayed graft function. The pathophysiological contribution...
- 16From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground Hypermethylation in the promoter regions is associated with the suppression of gene expression and has been considered a potential molecular marker for several tumor types, including head and neck squamous...
- 17From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground The effect of the addition of fotemustine and/or interferon (IFN) to standard therapy with dacarbazine alone in patients with advanced malignant melanoma was investigated in a multicenter, randomized 2x2...
- 18From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground Human colon adenocarcinoma cells are resistant to chemotherapeutic agents, such as anthracyclines, that induce death by increasing the reactive oxygen species. A number of studies have been focused on...
- 19From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground Neurodegenerative diseases such as Alzheimer's are associated with the aggregation of endogenous peptides and proteins that contribute to neuronal dysfunction and loss. The glymphatic system, a brain-wide...
- 20From: Journal of Translational Medicine. (Vol. 11, Issue 1) Peer-ReviewedBackground Adipose-derived stromal cells (ADSCs) are a good alternative to multipotent stem cells for regenerative medicine. Low tidal volume (LVT) has proved to be an effective ventilation strategy. However, it is...